LTOR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTOR4_HUMAN
• UniProt AC: Q0VGL1
• Protein Name: Ragulator complex protein LAMTOR4
• Gene Name: LAMTOR4
• Organism: Homo sapiens (Human).
• Sequence Length: 99
• Subcellular Localization: Lysosome .
• Protein Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated..
• Protein Sequence: MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHRGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTSALTQG -------CCCHHHHH		22814378
2	Acetylation	------MTSALTQGL ------CCCHHHHHH		20068231
2	Phosphorylation	------MTSALTQGL ------CCCHHHHHH		20068231
3	Phosphorylation	-----MTSALTQGLE -----CCCHHHHHHH		23186163
6	Phosphorylation	--MTSALTQGLERIP --CCCHHHHHHHHCH		20068231
64	Ubiquitination	RGMNVPFKRLSVVFG CCCCCCCCEEEEEEC		-
64	2-Hydroxyisobutyrylation	RGMNVPFKRLSVVFG CCCCCCCCEEEEEEC		-
64	Malonylation	RGMNVPFKRLSVVFG CCCCCCCCEEEEEEC		26320211
64	Acetylation	RGMNVPFKRLSVVFG CCCCCCCCEEEEEEC		25953088
67	Phosphorylation	NVPFKRLSVVFGEHT CCCCCEEEEEECCCE		-
88	Ubiquitination	GQRVFVVKRQNRGRE CEEEEEEEECCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTOR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTOR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTOR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S38A9_HUMAN	SLC38A9	physical	25567906

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.