CCR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCR3_HUMAN
• UniProt AC: P51677
• Protein Name: C-C chemokine receptor type 3
• Gene Name: CCR3
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection..
• Protein Sequence: MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
132	Phosphorylation	ILLTIDRYLAIVHAV HHHHHHHHHHHHHHH	9.20	9058802
204	Phosphorylation	HFHTLRMTIFCLVLP HHHHHHHHHHHHHHH	12.41	30257219
219	Phosphorylation	LLVMAICYTGIIKTL HHHHHHHHHHHHHHH	11.24	22210691
220	Phosphorylation	LVMAICYTGIIKTLL HHHHHHHHHHHHHHH	19.93	22210691
225	Phosphorylation	CYTGIIKTLLRCPSK HHHHHHHHHHCCCCH	22.18	22210691
231	Phosphorylation	KTLLRCPSKKKYKAI HHHHCCCCHHHHHHH	61.81	22210691
253	O-linked_Glycosylation	AVFFIFWTPYNVAIL HHHHHHHCCHHHHHH	12.73	29351928
262	O-linked_Glycosylation	YNVAILLSSYQSILF HHHHHHHHHHHHHHH	24.45	29351928
352	Phosphorylation	STAEPELSIVF---- CCCCCCCEECC----	18.29	30131370

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGR_HUMAN	FGR	physical	10527858
HCK_HUMAN	HCK	physical	10527858
CCL5_HUMAN	CCL5	physical	8642344
CCL7_HUMAN	CCL7	physical	8642344
CCL2_HUMAN	CCL2	physical	8642344
CCL11_HUMAN	CCL11	physical	8642344

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.