KAD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAD4_HUMAN
• UniProt AC: P27144
• Protein Name: Adenylate kinase 4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03170}
• Gene Name: AK4 {ECO:0000255|HAMAP-Rule:MF_03170}
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity..
• Protein Sequence: MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MASKLLRAVIL ----CCCHHHHHHHH	41.84	7379953
18	Acetylation	LGPPGSGKGTVCQRI HCCCCCCCHHHHHHH	53.78	26051181
35	Phosphorylation	NFGLQHLSSGHFLRE HHCCCHHCCCCHHHH	31.95	28857561
36	Phosphorylation	FGLQHLSSGHFLREN HCCCHHCCCCHHHHH	42.52	28857561
47	Phosphorylation	LRENIKASTEVGEMA HHHHHHHHHHHHHHH	21.79	27251275
48	Phosphorylation	RENIKASTEVGEMAK HHHHHHHHHHHHHHH	39.28	28857561
55	Acetylation	TEVGEMAKQYIEKSL HHHHHHHHHHHHHHH	42.18	27452117
57	Phosphorylation	VGEMAKQYIEKSLLV HHHHHHHHHHHHHCC	15.44	29496907
60	Succinylation	MAKQYIEKSLLVPDH HHHHHHHHHHCCCHH	36.52	-
60	Acetylation	MAKQYIEKSLLVPDH HHHHHHHHHHCCCHH	36.52	27452117
60	Succinylation	MAKQYIEKSLLVPDH HHHHHHHHHHCCCHH	36.52	-
75	Phosphorylation	VITRLMMSELENRRG HHHHHHHHHHHHCCC	25.68	110742971
93	Phosphorylation	LLDGFPRTLGQAEAL CCCCCCCCCCHHHHH	35.16	2421229
175	Acetylation	AARLRQYKDVAKPVI HHHHHHHHHHHHHHH	37.07	-
175	Succinylation	AARLRQYKDVAKPVI HHHHHHHHHHHHHHH	37.07	27452117
175	Malonylation	AARLRQYKDVAKPVI HHHHHHHHHHHHHHH	37.07	26320211
179	Malonylation	RQYKDVAKPVIELYK HHHHHHHHHHHHHHH	39.40	26320211
179	Succinylation	RQYKDVAKPVIELYK HHHHHHHHHHHHHHH	39.40	-
179	Succinylation	RQYKDVAKPVIELYK HHHHHHHHHHHHHHH	39.40	23954790
179	Acetylation	RQYKDVAKPVIELYK HHHHHHHHHHHHHHH	39.40	23954790
179	Ubiquitination	RQYKDVAKPVIELYK HHHHHHHHHHHHHHH	39.40	-
186	Malonylation	KPVIELYKSRGVLHQ HHHHHHHHHCCCEEE	46.42	26320211
186	Succinylation	KPVIELYKSRGVLHQ HHHHHHHHHCCCEEE	46.42	-
186	Acetylation	KPVIELYKSRGVLHQ HHHHHHHHHCCCEEE	46.42	23236377
186	Succinylation	KPVIELYKSRGVLHQ HHHHHHHHHCCCEEE	46.42	27452117
188	Methylation	VIELYKSRGVLHQFS HHHHHHHCCCEEECC	34.78	-
195	Phosphorylation	RGVLHQFSGTETNKI CCCEEECCCCCCCCH	37.93	27732954
197	Phosphorylation	VLHQFSGTETNKIWP CEEECCCCCCCCHHH	38.14	27732954
199	Phosphorylation	HQFSGTETNKIWPYV EECCCCCCCCHHHHH	41.47	27732954
205	Phosphorylation	ETNKIWPYVYTLFSN CCCCHHHHHHHHHCC	7.35	82293
219	Phosphorylation	NKITPIQSKEAY--- CCCCCCCCCCCC---	32.93	28857561
220	Ubiquitination	KITPIQSKEAY---- CCCCCCCCCCC----	29.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KEAP1_HUMAN	KEAP1	physical	21900206
A4_HUMAN	APP	physical	21832049
EPHA8_HUMAN	EPHA8	physical	21988832
CEP19_HUMAN	CEP19	physical	21988832
WIPI3_HUMAN	WDR45B	physical	26186194

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00718: Adefovir Dipivoxil
• DB00300: Tenofovir