SDC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDC4_HUMAN
• UniProt AC: P31431
• Protein Name: Syndecan-4
• Gene Name: SDC4
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Isoform 1: Membrane ; Single-pass type I membrane protein . Secreted . Shedding of the ectodomain produces a soluble form.; Isoform 2: Secreted.
• Protein Description: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. [PubMed: 22660413]
• Protein Sequence: MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	O-linked_Glycosylation	VAESIRETEVIDPQD HHHHHHHCCCCCHHH	26.21	OGP
39	O-linked_Glycosylation	LLEGRYFSGALPDDE HHCCCCCCCCCCCCC	17.77	-
61	O-linked_Glycosylation	ESDDFELSGSGDLDD CCCCCCCCCCCCHHH	24.58	-
63	O-linked_Glycosylation	DDFELSGSGDLDDLE CCCCCCCCCCHHHHH	26.26	-
97	O-linked_Glycosylation	PERAGSGSQVPTEPK CCCCCCCCCCCCCCC	29.69	55824389
97	Phosphorylation	PERAGSGSQVPTEPK CCCCCCCCCCCCCCC	29.69	28348404
101	O-linked_Glycosylation	GSGSQVPTEPKKLEE CCCCCCCCCCCCCCC	67.09	55824393
101	Phosphorylation	GSGSQVPTEPKKLEE CCCCCCCCCCCCCCC	67.09	24719451
104	Ubiquitination	SQVPTEPKKLEENEV CCCCCCCCCCCCCCC	64.85	-
117	O-linked_Glycosylation	EVIPKRISPVEESED CCCCCCCCCCCCCCC	27.25	55832651
126	O-linked_Glycosylation	VEESEDVSNKVSMSS CCCCCCCCCCCCCCC	43.16	55832655
134	Phosphorylation	NKVSMSSTVQGSNIF CCCCCCCCCCCCCHH	15.00	-
174	Ubiquitination	LLMYRMKKKDEGSYD HHHHHHHHCCCCCCC	56.99	-
179	Phosphorylation	MKKKDEGSYDLGKKP HHHCCCCCCCCCCCC	17.27	27794612
180	Phosphorylation	KKKDEGSYDLGKKPI HHCCCCCCCCCCCCC	26.50	27259358
190	Ubiquitination	GKKPIYKKAPTNEFY CCCCCCCCCCCCCCC	42.50	21906983
193	Phosphorylation	PIYKKAPTNEFYA-- CCCCCCCCCCCCC--	52.84	26356563
197	Phosphorylation	KAPTNEFYA------ CCCCCCCCC------	12.77	27273156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	Y	Phosphorylation	Kinase	SRC	P12931	PSP
197	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIPC1_HUMAN	GIPC1	physical	10911369
DVL1_HUMAN	DVL1	physical	20639201
TGFB3_HUMAN	TGFB3	physical	21988832
TANK_HUMAN	TANK	physical	21988832
SGTA_HUMAN	SGTA	physical	25416956
HRSL4_HUMAN	RARRES3	physical	27279133

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197, AND MASSSPECTROMETRY.
PubMed: 19534553

"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197, AND MASSSPECTROMETRY.
PubMed: 17389395

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197, AND MASSSPECTROMETRY.
PubMed: 18083107