TGFB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGFB3_HUMAN
• UniProt AC: P10600
• Protein Name: Transforming growth factor beta-3
• Gene Name: TGFB3
• Organism: Homo sapiens (Human).
• Sequence Length: 412
• Subcellular Localization: Secreted.
• Protein Description: Involved in embryogenesis and cell differentiation..
• Protein Sequence: MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	AIRGQILSKLRLTSP HHHHHHHHHHCCCCC	31.13	24719451
50	Ubiquitination	IRGQILSKLRLTSPP HHHHHHHHHCCCCCC	33.89	-
74	N-linked_Glycosylation	YQVLALYNSTRELLE HHHHHHHHHHHHHHH	37.44	UniProtKB CARBOHYD
135	N-linked_Glycosylation	TSKVFRFNVSSVEKN CCEEEEEEHHHHHHC	28.62	UniProtKB CARBOHYD
142	N-linked_Glycosylation	NVSSVEKNRTNLFRA EHHHHHHCCCCEEEE	42.37	UniProtKB CARBOHYD
162	Trimethylation	RVPNPSSKRNEQRIE ECCCCCCCCCHHHEE	64.68	-
162	Methylation	RVPNPSSKRNEQRIE ECCCCCCCCCHHHEE	64.68	23644510
185	Phosphorylation	EHIAKQRYIGGKNLP HHHHHCCEECCCCCC	11.04	22817900
293	Methylation	HRLDNPGQGGQRKKR HHCCCCCCCCHHHHH	54.84	26797129
299	Acetylation	GQGGQRKKRALDTNY CCCCHHHHHHCCCCC	45.13	7483907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGFB3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
293	Q	Methylation	Methylated at Gln-293 by N6AMT1.	26797129

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGFB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGFR2_HUMAN	TGFBR2	physical	12729750

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 107970: Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1)
• 615582: Rienhoff syndrome (RNHF)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.