GTR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTR5_HUMAN
• UniProt AC: P22732
• Protein Name: Solute carrier family 2, facilitated glucose transporter member 5
• Gene Name: SLC2A5
• Organism: Homo sapiens (Human).
• Sequence Length: 501
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma . Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell
• Protein Description: Functions as a fructose transporter that has only low activity with other monosaccharides. [PubMed: 8333543 Can mediate the uptake of 2-deoxyglucose, but with low efficiency]
• Protein Sequence: MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEQQDQSM -------CHHHHHHH	10.67	22814378
9	Ubiquitination	EQQDQSMKEGRLTLV HHHHHHHHHHHHHHH	63.36	-
51	N-linked_Glycosylation	LLMQQFYNETYYGRT HHHHHHHCCCCCCCC	36.10	UniProtKB CARBOHYD
120	Methylation	AILMGCSRVATSFEL HHHHCCCCCHHHHHH	26.60	-
123	Phosphorylation	MGCSRVATSFELIII HCCCCCHHHHHHHHH	30.96	28111955
124	Phosphorylation	GCSRVATSFELIIIS CCCCCHHHHHHHHHH	13.64	28111955
131	Phosphorylation	SFELIIISRLLVGIC HHHHHHHHHHHHHHH	13.38	28111955
199	Phosphorylation	WPILLGLTGVPAALQ HHHHHHHCCHHHHHH	34.04	18452278
242	Phosphorylation	QTLRGWDSVDREVAE HHHHCHHHHCHHHHH	21.29	28857561
477	Ubiquitination	EINQIFTKMNKVSEV HHHHHHHHHHCHHCC	29.72	-
482	Phosphorylation	FTKMNKVSEVYPEKE HHHHHCHHCCCCCHH	23.97	26307563
485	Phosphorylation	MNKVSEVYPEKEELK HHCHHCCCCCHHHHC	11.13	25693802
488	Ubiquitination	VSEVYPEKEELKELP HHCCCCCHHHHCCCC	52.57	-
492	Ubiquitination	YPEKEELKELPPVTS CCCHHHHCCCCCCCC	61.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTR5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFOX3_HUMAN	RBFOX3	physical	28514442
CTR3_HUMAN	SLC7A3	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
LMBD2_HUMAN	LMBRD2	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
FACE1_HUMAN	ZMPSTE24	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
OSBL6_HUMAN	OSBPL6	physical	28514442
ECM29_HUMAN	KIAA0368	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.