| UniProt ID | RFOX3_HUMAN | |
|---|---|---|
| UniProt AC | A6NFN3 | |
| Protein Name | RNA binding protein fox-1 homolog 3 | |
| Gene Name | RBFOX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 312 | |
| Subcellular Localization | Nucleus . Cytoplasm . Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment. | |
| Protein Description | Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).. | |
| Protein Sequence | MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPTEHGMTLYTPAQTHPEQPGSEASTQPIAGTQTVPQTDEAAQTDSQPLHPSDPTEKQQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSSDADRAREKLNGTIVEGRKIEVNNATARVMTNKKTGNPYTNGWKLNPVVGAVYGPEFYAVTGFPYPTTGTAVAYRGAHLRGRGRAVYNTFRAAPPPPPIPTYGAVVYQDGFYGAEIYGGYAAYRYAQPAAAAAAYSDSYGRVYAAADPYHHTIGPAATYSIGTM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 63 | Phosphorylation | EQPGSEASTQPIAGT CCCCCCCCCCCCCCC | 24.43 | 24275569 | |
| 116 | Methylation | RFRDPDLRQMFGQFG CCCCHHHHHHHHHHC | 33.04 | - | |
| 167 | Ubiquitination | GTIVEGRKIEVNNAT CEEEECEEEEECCCE | 54.82 | - | |
| 187 | Phosphorylation | NKKTGNPYTNGWKLN CCCCCCCCCCCCCCC | 19.48 | - | |
| 188 | Phosphorylation | KKTGNPYTNGWKLNP CCCCCCCCCCCCCCC | 28.63 | - | |
| 223 | Asymmetric dimethylarginine | TGTAVAYRGAHLRGR CCCEEEECCCCCCCC | 26.53 | - | |
| 223 | Methylation | TGTAVAYRGAHLRGR CCCEEEECCCCCCCC | 26.53 | - | |
| 272 | Asymmetric dimethylarginine | YGGYAAYRYAQPAAA ECCCEEHHHCCHHHH | 18.65 | - | |
| 272 | Methylation | YGGYAAYRYAQPAAA ECCCEEHHHCCHHHH | 18.65 | - | |
| 291 (in isoform 2) | Phosphorylation | - | 6.80 | 28122231 | |
| 297 (in isoform 2) | Phosphorylation | - | 13.54 | 28122231 | |
| 300 (in isoform 2) | Phosphorylation | - | 17.83 | 28122231 | |
| 306 (in isoform 2) | Phosphorylation | - | 21.65 | 28122231 | |
| 307 (in isoform 2) | Phosphorylation | - | 8.12 | 28122231 | |
| 308 (in isoform 2) | Phosphorylation | - | 15.36 | 28122231 | |
| 311 (in isoform 2) | Phosphorylation | - | 20.31 | 28122231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RFOX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFOX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFOX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RFOX3_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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