dbPTM

CTR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CTR3_HUMAN
UniProt AC	Q8WY07
Protein Name	Cationic amino acid transporter 3
Gene Name	SLC7A3
Organism	Homo sapiens (Human).
Sequence Length	619
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner..
Protein Sequence	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSRKSRAKTVDLDPGTLYVHSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	AFRRFGQKLVRRRTL HHHHHHHHHHHHHHH	49.70	-
18	Phosphorylation	QKLVRRRTLESGMAE HHHHHHHHHHHCCHH	32.82	24173317
26	Phosphorylation	LESGMAETRLARCLS HHHCCHHHHHHHHHH	22.80	-
232	N-linked_Glycosylation	ELAMAELNDTYSLGP HHHHHHCCCCEEECC	30.96	UniProtKB CARBOHYD
346	Phosphorylation	VGSLCALSTSLLGSM HHHHHHHCHHHHHHC	9.45	-
348	Phosphorylation	SLCALSTSLLGSMFP HHHHHCHHHHHHCCC	20.44	-
352	Phosphorylation	LSTSLLGSMFPMPRV HCHHHHHHCCCCCHH	19.74	-
411	Phosphorylation	TDLVDLMSIGTLLAY HHHHHHHHHHHHHHH	25.76	-
414	Phosphorylation	VDLMSIGTLLAYSLV HHHHHHHHHHHHHHH	19.54	-
605	Ubiquitination	PSRKSRAKTVDLDPG CCCCCCCEEECCCCC	48.23	-
606	Phosphorylation	SRKSRAKTVDLDPGT CCCCCCEEECCCCCC	20.47	21406692
613	Phosphorylation	TVDLDPGTLYVHSV- EECCCCCCEEEEEC-	21.94	29978859
615	Phosphorylation	DLDPGTLYVHSV--- CCCCCCEEEEEC---	8.92	29978859
618	Phosphorylation	PGTLYVHSV------ CCCEEEEEC------	21.34	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CTR3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CTR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CTR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CTR3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00125	L-Arginine
DB00123	L-Lysine
DB00129	L-Ornithine

Regulatory Network of CTR3_HUMAN

Related Literatures of Post-Translational Modification