FITM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FITM2_HUMAN
• UniProt AC: Q8N6M3
• Protein Name: Fat storage-inducing transmembrane protein 2
• Gene Name: FITM2
• Organism: Homo sapiens (Human).
• Sequence Length: 262
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization..
• Protein Sequence: MEHLERCEWLLRGTLVRAAVRRYLPWALVASMLAGSLLKELSPLPESYLSNKRNVLNVYFVKVAWAWTFCLLLPFIALTNYHLTGKAGLVLRRLSTLLVGTAIWYICTSIFSNIEHYTGSCYQSPALEGVRKEHQSKQQCHQEGGFWHGFDISGHSFLLTFCALMIVEEMSVLHEVKTDRSHCLHTAITTLVVALGILTFIWVLMFLCTAVYFHNLSQKVFGTLFGLLSWYGTYGFWYPKAFSPGLPPQSCSLNLKQDSYKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	VASMLAGSLLKELSP HHHHHHHHHHHHHCC	25.56	24719451
52	Acetylation	PESYLSNKRNVLNVY CHHHHCCCCCEEHHH	41.81	2401541
52	2-Hydroxyisobutyrylation	PESYLSNKRNVLNVY CHHHHCCCCCEEHHH	41.81	-
259	Phosphorylation	SLNLKQDSYKK---- CCCCCCHHCCC----	36.04	28857561
260	Phosphorylation	LNLKQDSYKK----- CCCCCHHCCC-----	30.96	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FITM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FITM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FITM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FITM2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.