MAGA8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGA8_HUMAN
• UniProt AC: P43361
• Protein Name: Melanoma-associated antigen 8
• Gene Name: MAGEA8
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Protein Description: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression..
• Protein Sequence: MLLGQKSQRYKAEEGLQAQGEAPGLMDVQIPTAEEQKAASSSSTLIMGTLEEVTDSGSPSPPQSPEGASSSLTVTDSTLWSQSDEGSSSNEEEGPSTSPDPAHLESLFREALDEKVAELVRFLLRKYQIKEPVTKAEMLESVIKNYKNHFPDIFSKASECMQVIFGIDVKEVDPAGHSYILVTCLGLSYDGLLGDDQSTPKTGLLIIVLGMILMEGSRAPEEAIWEALSVMGLYDGREHSVYWKLRKLLTQEWVQENYLEYRQAPGSDPVRYEFLWGPRALAETSYVKVLEHVVRVNARVRISYPSLHEEALGEEKGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	GSPSPPQSPEGASSS CCCCCCCCCCCCCCC	30.60	-
135	Ubiquitination	QIKEPVTKAEMLESV CCCCCCCHHHHHHHH	42.45	-
144	Ubiquitination	EMLESVIKNYKNHFP HHHHHHHHHHHHHCH	52.66	-
147	Ubiquitination	ESVIKNYKNHFPDIF HHHHHHHHHHCHHHH	54.03	-
155	Phosphorylation	NHFPDIFSKASECMQ HHCHHHHHHHHHHHH	27.87	24719451
229	Phosphorylation	EAIWEALSVMGLYDG HHHHHHHHHCCCCCC	19.67	-
234	Phosphorylation	ALSVMGLYDGREHSV HHHHCCCCCCCCHHH	15.60	-
288	Methylation	LAETSYVKVLEHVVR HHCCCHHHHHHHHHH	32.63	-
288	Ubiquitination	LAETSYVKVLEHVVR HHCCCHHHHHHHHHH	32.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGA8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGA8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGA8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAGB4_HUMAN	MAGEB4	physical	25416956
PKD2_HUMAN	PKD2	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
GRAN_HUMAN	GCA	physical	25416956
LXN_HUMAN	LXN	physical	25416956
BEX5_HUMAN	BEX5	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.