| UniProt ID | GRAN_HUMAN | |
|---|---|---|
| UniProt AC | P28676 | |
| Protein Name | Grancalcin | |
| Gene Name | GCA | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 217 | |
| Subcellular Localization |
Cytoplasm . Cytoplasmic granule membrane Peripheral membrane protein Cytoplasmic side. Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. |
|
| Protein Description | Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.. | |
| Protein Sequence | MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 103 | Methylation | IMIAMLDRDHTGKMG EEEEECCCCCCCCCC | 33.38 | - | |
| 106 | Phosphorylation | AMLDRDHTGKMGFNA EECCCCCCCCCCHHH | 42.67 | - | |
| 159 | Phosphorylation | GYRLSPQTLTTIVKR CCCCCHHHHHHHHHH | 29.47 | 23403867 | |
| 161 | Phosphorylation | RLSPQTLTTIVKRYS CCCHHHHHHHHHHHC | 20.19 | 23403867 | |
| 162 | Phosphorylation | LSPQTLTTIVKRYSK CCHHHHHHHHHHHCC | 27.21 | 23403867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GRAN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GRAN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GRAN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SORCN_HUMAN | SRI | physical | 12804766 | |
| GRAN_HUMAN | GCA | physical | 10903868 | |
| PLSL_HUMAN | LCP1 | physical | 11279160 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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