SORCN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SORCN_HUMAN
• UniProt AC: P30626
• Protein Name: Sorcin
• Gene Name: SRI
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
• Protein Description: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels..
• Protein Sequence: MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Ubiquitination	SGIAGGYKPFNLETC CCCCCCCCCCCHHHH	46.54	21890473
68	Acetylation	SGIAGGYKPFNLETC CCCCCCCCCCCHHHH	46.54	26051181
80	Phosphorylation	ETCRLMVSMLDRDMS HHHHHHHHHHCCCCC	10.32	21712546
87	Phosphorylation	SMLDRDMSGTMGFNE HHHCCCCCCCCCHHH	35.09	21712546
111	Phosphorylation	GWRQHFISFDTDRSG HHHHHEEECCCCCCC	19.00	20071362
112	Acetylation	WRQHFISFDTDRSGT HHHHEEECCCCCCCC	11.37	-
112	Ubiquitination	WRQHFISFDTDRSGT HHHHEEECCCCCCCC	11.37	21890473
112	Ubiquitination	WRQHFISFDTDRSGT HHHHEEECCCCCCCC	11.37	21890473
114	Phosphorylation	QHFISFDTDRSGTVD HHEEECCCCCCCCCC	31.16	-
116	Methylation	FISFDTDRSGTVDPQ EEECCCCCCCCCCHH	38.79	115917749
117	Phosphorylation	ISFDTDRSGTVDPQE EECCCCCCCCCCHHH	41.44	22210691
119	Phosphorylation	FDTDRSGTVDPQELQ CCCCCCCCCCHHHHH	24.00	22210691
127	Acetylation	VDPQELQKALTTMGF CCHHHHHHHHHHCCC	58.97	23236377
127	Ubiquitination	VDPQELQKALTTMGF CCHHHHHHHHHHCCC	58.97	21906983
131	Ubiquitination	ELQKALTTMGFRLSP HHHHHHHHCCCCCCH	19.02	-
132	Sulfoxidation	LQKALTTMGFRLSPQ HHHHHHHCCCCCCHH	3.93	30846556
137	Phosphorylation	TTMGFRLSPQAVNSI HHCCCCCCHHHHHHH	15.65	25627689
146	2-Hydroxyisobutyrylation	QAVNSIAKRYSTNGK HHHHHHHHHHCCCCC	50.64	-
146	Ubiquitination	QAVNSIAKRYSTNGK HHHHHHHHHHCCCCC	50.64	-
146	Acetylation	QAVNSIAKRYSTNGK HHHHHHHHHHCCCCC	50.64	25953088
149	Phosphorylation	NSIAKRYSTNGKITF HHHHHHHCCCCCCCH	21.30	-
150	Phosphorylation	SIAKRYSTNGKITFD HHHHHHCCCCCCCHH	38.77	-
155	Phosphorylation	YSTNGKITFDDYIAC HCCCCCCCHHHHHHH	25.21	-
162	Glutathionylation	TFDDYIACCVKLRAL CHHHHHHHHHHHHHH	1.67	22555962
170	Phosphorylation	CVKLRALTDSFRRRD HHHHHHHCHHHHCHH	28.72	30266825
172	Phosphorylation	KLRALTDSFRRRDTA HHHHHCHHHHCHHCC	18.54	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
155	T	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SORCN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SORCN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACO2_HUMAN	CALCOCO2	physical	16189514
SORCN_HUMAN	SRI	physical	16189514
GRAN_HUMAN	GCA	physical	12804766
ALG2_HUMAN	ALG2	physical	12804766
RYR2_HUMAN	RYR2	physical	7592856
SORCN_HUMAN	SRI	physical	11714909
ANXA7_HUMAN	ANXA7	physical	9268363
STAT3_HUMAN	STAT3	physical	21988832
CACO2_HUMAN	CALCOCO2	physical	18330356
GRAN_HUMAN	GCA	physical	18330356
SORCN_HUMAN	SRI	physical	18330356
STAT3_HUMAN	STAT3	physical	18330356
HTF4_HUMAN	TCF12	physical	25416956
CACO2_HUMAN	CALCOCO2	physical	25416956
PRR13_HUMAN	PRR13	physical	25416956
C10_HUMAN	C12orf57	physical	26344197
MPI_HUMAN	MPI	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26344197
PIR_HUMAN	PIR	physical	26344197
SODC_HUMAN	SOD1	physical	26344197
SSNA1_HUMAN	SSNA1	physical	26344197
TIAR_HUMAN	TIAL1	physical	26344197
TKT_HUMAN	TKT	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.