| UniProt ID | MPI_HUMAN | |
|---|---|---|
| UniProt AC | P34949 | |
| Protein Name | Mannose-6-phosphate isomerase | |
| Gene Name | MPI | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 423 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.. | |
| Protein Sequence | MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAPRVFPL ------CCCCCEEEC | 26.60 | 19413330 | |
| 23 | Phosphorylation | YAWGKMGSNSEVARL HHCCCCCCHHHHHHH | 33.41 | 30622161 | |
| 25 | Phosphorylation | WGKMGSNSEVARLLA CCCCCCHHHHHHHHH | 34.83 | 30622161 | |
| 44 | Ubiquitination | LAQIAEDKPYAELWM HHHHHCCCCCCEEEC | 31.28 | - | |
| 46 | Phosphorylation | QIAEDKPYAELWMGT HHHCCCCCCEEECCC | 20.60 | 27642862 | |
| 60 | Ubiquitination | THPRGDAKILDNRIS CCCCCCHHHHCCHHC | 48.84 | - | |
| 65 | Methylation | DAKILDNRISQKTLS CHHHHCCHHCHHHHH | 29.60 | 115483641 | |
| 67 | Phosphorylation | KILDNRISQKTLSQW HHHCCHHCHHHHHHH | 23.53 | 30622161 | |
| 69 (in isoform 2) | Ubiquitination | - | 44.64 | 21890473 | |
| 69 (in isoform 1) | Ubiquitination | - | 44.64 | 21890473 | |
| 69 | Ubiquitination | LDNRISQKTLSQWIA HCCHHCHHHHHHHHH | 44.64 | 21890473 | |
| 70 | Phosphorylation | DNRISQKTLSQWIAE CCHHCHHHHHHHHHH | 24.81 | 30622161 | |
| 72 | Phosphorylation | RISQKTLSQWIAENQ HHCHHHHHHHHHHCC | 28.80 | 30622161 | |
| 85 | Ubiquitination | NQDSLGSKVKDTFNG CCCCCCCCCHHHHCC | 52.05 | - | |
| 87 | Ubiquitination | DSLGSKVKDTFNGNL CCCCCCCHHHHCCCC | 55.58 | - | |
| 99 | Ubiquitination | GNLPFLFKVLSVETP CCCCEEEEEEEECCC | 44.40 | - | |
| 102 | Phosphorylation | PFLFKVLSVETPLSI CEEEEEEEECCCCEE | 22.39 | 23312004 | |
| 105 | Phosphorylation | FKVLSVETPLSIQAH EEEEEECCCCEECCC | 27.63 | 30622161 | |
| 108 | Phosphorylation | LSVETPLSIQAHPNK EEECCCCEECCCCCH | 17.54 | 9525984 | |
| 115 | Ubiquitination | SIQAHPNKELAEKLH EECCCCCHHHHHHHH | 59.56 | - | |
| 163 | Sumoylation | EIVTFLKKVPEFQFL HHHHHHHCCCCCEEE | 66.23 | - | |
| 163 | Ubiquitination | EIVTFLKKVPEFQFL HHHHHHHCCCCCEEE | 66.23 | - | |
| 218 | 2-Hydroxyisobutyrylation | EQLNLLVKRISQQAA HHHHHHHHHHHHHHH | 43.94 | - | |
| 218 | Ubiquitination | EQLNLLVKRISQQAA HHHHHHHHHHHHHHH | 43.94 | - | |
| 287 | Sulfoxidation | KGDCVECMACSDNTV CCCEEEEEEECCCCC | 2.39 | 21406390 | |
| 320 | Ubiquitination | SYTPSSSKDRLFLPT CCCCCCCCCCEECCC | 49.14 | - | |
| 322 | Methylation | TPSSSKDRLFLPTRS CCCCCCCCEECCCCC | 30.95 | 115483633 | |
| 338 | Phosphorylation | EDPYLSIYDPPVPDF CCCCCEECCCCCCCC | 21.01 | 27642862 | |
| 349 | Ubiquitination | VPDFTIMKTEVPGSV CCCCEEEEEECCCCC | 37.37 | - | |
| 366 | Phosphorylation | YKVLALDSASILLMV EEEEEECCCCEEEEE | 25.43 | - | |
| 376 | Phosphorylation | ILLMVQGTVIASTPT EEEEEECEEEEECCC | 7.52 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MPI_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPI_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPI_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| TGM1_HUMAN | TGM1 | physical | 26186194 | |
| INVO_HUMAN | IVL | physical | 26186194 | |
| S10AE_HUMAN | S100A14 | physical | 26186194 | |
| MIF_HUMAN | MIF | physical | 26344197 | |
| NECP1_HUMAN | NECAP1 | physical | 26344197 | |
| NECP2_HUMAN | NECAP2 | physical | 26344197 | |
| PCBP1_HUMAN | PCBP1 | physical | 26344197 | |
| PIPNB_HUMAN | PITPNB | physical | 26344197 | |
| AACT_HUMAN | SERPINA3 | physical | 28514442 | |
| SPB4_HUMAN | SERPINB4 | physical | 28514442 | |
| TGM1_HUMAN | TGM1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| 602579 | Congenital disorder of glycosylation 1B (CDG1B) | |||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
