C10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C10_HUMAN
• UniProt AC: Q99622
• Protein Name: Protein C10
• Gene Name: C12orf57
• Organism: Homo sapiens (Human).
• Sequence Length: 126
• Subcellular Localization: Cytoplasm .
• Protein Description: In brain, may be required for corpus callusum development..
• Protein Sequence: MASASTQPAALSAEQAKVVLAEVIQAFSAPENAVRMDEARDNACNDMGKMLQFVLPVATQIQQEVIKAYGFSCDGEGVLKFARLVKSYEAQDPEIASLSGKLKALFLPPMTLPPHGPAAGGSVAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASASTQPA ------CCCCCCCCC	17.50	22223895
3	Phosphorylation	-----MASASTQPAA -----CCCCCCCCCC	22.81	24300666
5	Phosphorylation	---MASASTQPAALS ---CCCCCCCCCCCC	25.69	24300666
6	Phosphorylation	--MASASTQPAALSA --CCCCCCCCCCCCH	37.98	24300666
12	Phosphorylation	STQPAALSAEQAKVV CCCCCCCCHHHHHHH	25.65	24300666
49	Acetylation	NACNDMGKMLQFVLP HHHHHHHHHHHHHHH	29.78	7406633
59	Phosphorylation	QFVLPVATQIQQEVI HHHHHHHHHHHHHHH	26.83	30622161
80	Ubiquitination	CDGEGVLKFARLVKS CCCCHHHHHHHHHHH	34.27	21890473
80	Acetylation	CDGEGVLKFARLVKS CCCCHHHHHHHHHHH	34.27	25953088
86	Ubiquitination	LKFARLVKSYEAQDP HHHHHHHHHHCCCCH	52.49	-
97	Phosphorylation	AQDPEIASLSGKLKA CCCHHHHHHHHCCHH	28.82	27251275
101	Acetylation	EIASLSGKLKALFLP HHHHHHHCCHHHCCC	43.36	23954790
101	Ubiquitination	EIASLSGKLKALFLP HHHHHHHCCHHHCCC	43.36	-
103	Ubiquitination	ASLSGKLKALFLPPM HHHHHCCHHHCCCCC	46.67	-
122	Phosphorylation	HGPAAGGSVAAS--- CCCCCCCCCCCC---	13.99	28111955
126	Phosphorylation	AGGSVAAS------- CCCCCCCC-------	30.89	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLXB2_HUMAN	PLXNB2	physical	22939629
FKBP7_HUMAN	FKBP7	physical	22939629
TACC1_HUMAN	TACC1	physical	22939629
LETM1_HUMAN	LETM1	physical	22939629
SNP23_HUMAN	SNAP23	physical	22939629
PALM2_HUMAN	PALM2	physical	22939629
CO1A1_HUMAN	COL1A1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 218340: Temtamy syndrome (TEMTYS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330