FKBP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKBP7_HUMAN
• UniProt AC: Q9Y680
• Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP7
• Gene Name: FKBP7
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: PPIases accelerate the folding of proteins during protein synthesis..
• Protein Sequence: MPKTMHFLFRFIVFFYLWGLFTAQRQKKEESTEEVKIEVLHRPENCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	N-linked_Glycosylation	EVLHRPENCSKTSKK EEEECCCCCCCCCCC	37.74	UniProtKB CARBOHYD
69	Phosphorylation	GYLAKDGSKFYCSRT CEECCCCCEEEEECC	29.71	-
70	Acetylation	YLAKDGSKFYCSRTQ EECCCCCEEEEECCC	45.97	25953088
72	Phosphorylation	AKDGSKFYCSRTQNE CCCCCEEEEECCCCC	8.02	-
74	Phosphorylation	DGSKFYCSRTQNEGH CCCEEEEECCCCCCC	27.30	-
100	Sulfoxidation	IKGLDIAMTDMCPGE HCCCCEEECCCCCCC	3.14	30846556
103	Sulfoxidation	LDIAMTDMCPGEKRK CCEEECCCCCCCCCE	1.87	30846556
104	Glutathionylation	DIAMTDMCPGEKRKV CEEECCCCCCCCCEE	4.33	22555962
116	Phosphorylation	RKVVIPPSFAYGKEG CEEEECCHHHCCCCC	19.70	-
116 (in isoform 2)	Phosphorylation	-	19.70	-
158	N-linked_Glycosylation	IETFKQIDMDNDRQL HHHHHEECCCCCCCC	40.81	UniProtKB CARBOHYD
159	Sulfoxidation	ETFKQIDMDNDRQLS HHHHEECCCCCCCCC	35.15	30846556
247	Phosphorylation	-------------------------------- --------------------------------	27.88	25022875

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKBP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKBP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKBP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRF2_HUMAN	IRF2	physical	21988832
ANM6_HUMAN	PRMT6	physical	23455924
ATP5J_HUMAN	ATP5J	physical	26344197
CHSP1_HUMAN	CARHSP1	physical	26344197
DUT_HUMAN	DUT	physical	26344197
GSTO1_HUMAN	GSTO1	physical	26344197
HINT1_HUMAN	HINT1	physical	26344197
IPYR_HUMAN	PPA1	physical	26344197
TKT_HUMAN	TKT	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.