ALG2_HUMAN - dbPTM
ALG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALG2_HUMAN
UniProt AC Q9H553
Protein Name Alpha-1,3/1,6-mannosyltransferase ALG2
Gene Name ALG2
Organism Homo sapiens (Human).
Sequence Length 416
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate..
Protein Sequence MAEEQGRERDSVPKPSVLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFAESRELPVRCAGDWLPRGLGWGGRGAAVCAYVRMVFLALYVLFLADEEFDVVVCDQVSACIPVFRLARRRKKILFYCHFPDLLLTKRDSFLKRLYRAPIDWIEEYTTGMADCILVNSQFTAAVFKETFKSLSHIDPDVLYPSLNVTSFDSVVPEKLDDLVPKGKKFLLLSINRYERKKNLTLALEALVQLRGRLTSQDWERVHLIVAGGYDERVLENVEHYQELKKMVQQSDLGQYVTFLRSFSDKQKISLLHSCTCVLYTPSNEHFGIVPLEAMYMQCPVIAVNSGGPLESIDHSVTGFLCEPDPVHFSEAIEKFIREPSLKATMGLAGRARVKEKFSPEAFTEQLYRYVTKLLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14UbiquitinationRERDSVPKPSVLFLH
CCCCCCCCCCEEEEC		48.01-
46PhosphorylationALQARGCSVKIWTAH
HHHHCCCEEEEEECC		29.3072838403
48UbiquitinationQARGCSVKIWTAHYD
HHCCCEEEEEECCCC		19.07-
146UbiquitinationFPDLLLTKRDSFLKR
CHHHHCCCCHHHHHH		54.93-
149PhosphorylationLLLTKRDSFLKRLYR
HHCCCCHHHHHHHHH		36.1924719451
152UbiquitinationTKRDSFLKRLYRAPI
CCCHHHHHHHHHCCC		38.04-
165PhosphorylationPIDWIEEYTTGMADC
CCHHHHHHCCCCCCE		9.2326074081
166PhosphorylationIDWIEEYTTGMADCI
CHHHHHHCCCCCCEE		21.8326074081
167PhosphorylationDWIEEYTTGMADCIL
HHHHHHCCCCCCEEE		24.8626074081
177PhosphorylationADCILVNSQFTAAVF
CCEEEECCHHHHHHH		21.1326074081
180PhosphorylationILVNSQFTAAVFKET
EEECCHHHHHHHHHH		13.1826074081
189UbiquitinationAVFKETFKSLSHIDP
HHHHHHHHHHHCCCC		58.88-
192 (in isoform 2)Ubiquitination-26.0321906983
215UbiquitinationFDSVVPEKLDDLVPK
CCCCCCHHHHHHCCC		51.66-
222UbiquitinationKLDDLVPKGKKFLLL
HHHHHCCCCCEEEEE		75.72-
230PhosphorylationGKKFLLLSINRYERK
CCEEEEEECCHHHHH		20.1420873877
255PhosphorylationVQLRGRLTSQDWERV
HHHHCCCCCCCCCCE		23.9923312004
256PhosphorylationQLRGRLTSQDWERVH
HHHCCCCCCCCCCEE		30.6323312004
281PhosphorylationVLENVEHYQELKKMV
HHHHHHHHHHHHHHH		7.09110758327
285UbiquitinationVEHYQELKKMVQQSD
HHHHHHHHHHHHHCH		37.762190698
285AcetylationVEHYQELKKMVQQSD
HHHHHHHHHHHHHCH		37.7626051181
285 (in isoform 1)Ubiquitination-37.7621906983
286UbiquitinationEHYQELKKMVQQSDL
HHHHHHHHHHHHCHH		57.86-
291PhosphorylationLKKMVQQSDLGQYVT
HHHHHHHCHHHHHHH		20.0825072903
296PhosphorylationQQSDLGQYVTFLRSF
HHCHHHHHHHHHHHC		10.3125072903
298PhosphorylationSDLGQYVTFLRSFSD
CHHHHHHHHHHHCCC		16.4225072903
302PhosphorylationQYVTFLRSFSDKQKI
HHHHHHHHCCCHHHH		31.1125072903
304PhosphorylationVTFLRSFSDKQKISL
HHHHHHCCCHHHHHH		45.1825072903
375UbiquitinationHFSEAIEKFIREPSL
CHHHHHHHHHHCCCH		39.72-
381PhosphorylationEKFIREPSLKATMGL
HHHHHCCCHHHHCCC		37.4452836489
383MethylationFIREPSLKATMGLAG
HHHCCCHHHHCCCCH		46.26-
397UbiquitinationGRARVKEKFSPEAFT
HHHHHHHHCCHHHHH		45.48-
399PhosphorylationARVKEKFSPEAFTEQ
HHHHHHCCHHHHHHH		32.6614645477
410PhosphorylationFTEQLYRYVTKLLV-
HHHHHHHHHHHHHC-		10.027345045
413UbiquitinationQLYRYVTKLLV----
HHHHHHHHHHC----		29.76-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALG2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALG2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALG2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TS101_HUMANTSG101physical
19520058
PDC6I_HUMANPDCD6IPphysical
19520058
TS101_HUMANTSG101physical
16004603
VP37A_HUMANVPS37Aphysical
16004603
VPS28_HUMANVPS28physical
16004603
PDC6I_HUMANPDCD6IPphysical
16004603
ALG2_HUMANALG2physical
16004603
HS90A_HUMANHSP90AA1physical
16004603
LAMP1_HUMANLAMP1physical
16004603
PDC6I_HUMANPDCD6IPphysical
20691033
TS101_HUMANTSG101physical
20691033
SC31A_HUMANSEC31Aphysical
20691033
ANXA7_HUMANANXA7physical
20691033
ANX11_HUMANANXA11physical
20691033
SHSA5_HUMANSHISA5physical
17889823
PLS3_HUMANPLSCR3physical
18256029
Drug and Disease Associations
Kegg Disease
H00118 Congenital disorders of glycosylation (CDG) type I
OMIM Disease
607906Congenital disorder of glycosylation 1I (CDG1I)
616228Myasthenic syndrome, congenital, 14 (CMS14)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALG2_HUMAN

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Related Literatures of Post-Translational Modification

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