NPM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPM3_HUMAN
• UniProt AC: O75607
• Protein Name: Nucleoplasmin-3
• Gene Name: NPM3
• Organism: Homo sapiens (Human).
• Sequence Length: 178
• Subcellular Localization: Nucleus .
• Protein Description: May act as a chaperone..
• Protein Sequence: MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAGTAAAL ------CCHHHHHHH	18.01	20068231
5	Phosphorylation	---MAAGTAAALAFL ---CCHHHHHHHHHH	14.38	20873877
13	Phosphorylation	AAALAFLSQESRTRA HHHHHHHCHHHCCCC	26.00	21955146
16	Phosphorylation	LAFLSQESRTRAGGV HHHHCHHHCCCCCCC	31.17	21955146
18	Phosphorylation	FLSQESRTRAGGVGG HHCHHHCCCCCCCCC	33.86	21406692
19	Methylation	LSQESRTRAGGVGGL HCHHHCCCCCCCCCC	30.08	115485511
27	Methylation	AGGVGGLRVPAPVTM CCCCCCCCCCCCEEE	35.33	24129315
41	Glutathionylation	MDSFFFGCELSGHTR ECEEEECEEECCCEE	3.93	22555962
53	Sumoylation	HTRSFTFKVEEEDDA CEEEEEEEEECCCCH	45.75	-
102	Acetylation	AVPVANLKLSCQPML EEEEECCEEECEECC	37.86	26051181
102	Ubiquitination	AVPVANLKLSCQPML EEEEECCEEECEECC	37.86	29967540
105	Glutathionylation	VANLKLSCQPMLSLD EECCEEECEECCCCC	8.36	22555962
125	Sumoylation	PPVTFRLKSGSGPVR CCEEEEECCCCCCEE	48.81	-
125	Ubiquitination	PPVTFRLKSGSGPVR CCEEEEECCCCCCEE	48.81	29967540
125	Sumoylation	PPVTFRLKSGSGPVR CCEEEEECCCCCCEE	48.81	-
126	Phosphorylation	PVTFRLKSGSGPVRI CEEEEECCCCCCEEE	42.66	21406692
128	Phosphorylation	TFRLKSGSGPVRITG EEEECCCCCCEEEEE	47.19	23403867
134	Phosphorylation	GSGPVRITGRHQIVT CCCCEEEEEEEEEEE	20.00	23403867
141	Phosphorylation	TGRHQIVTMSNDVSE EEEEEEEEEECCCCH	19.26	25137130
143	Phosphorylation	RHQIVTMSNDVSEEE EEEEEEEECCCCHHH	22.10	26552605
147	Phosphorylation	VTMSNDVSEEESEEE EEEECCCCHHHHHHH	42.00	17081983
151	Phosphorylation	NDVSEEESEEEEEDS CCCCHHHHHHHCCCC	54.29	17081983
158	Phosphorylation	SEEEEEDSDEEEVEL HHHHCCCCCHHHHHH	50.64	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CE126_HUMAN	KIAA1377	physical	16169070
NPM_HUMAN	NPM1	physical	22362753
NPM_HUMAN	NPM1	physical	22939629
NUCL_HUMAN	NCL	physical	22863883
NPM2_HUMAN	NPM2	physical	25416956
ARGL1_HUMAN	ARGLU1	physical	26344197
ATPB_HUMAN	ATP5B	physical	26344197
EF1G_HUMAN	EEF1G	physical	26344197
NUCL_HUMAN	NCL	physical	26344197
NPM_HUMAN	NPM1	physical	26344197
TPD53_HUMAN	TPD52L1	physical	26344197
1433E_HUMAN	YWHAE	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147; SER-151 ANDSER-158, AND MASS SPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147; SER-151 ANDSER-158, AND MASS SPECTROMETRY.
PubMed: 17081983