SALL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SALL1_HUMAN
• UniProt AC: Q9NSC2
• Protein Name: Sal-like protein 1
• Gene Name: SALL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1324
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional repressor involved in organogenesis..
• Protein Sequence: MSRRKQAKPQHFQSDPEVASLPRRDGDTEKGQPSRPTKSKDAHVCGRCCAEFFELSDLLLHKKNCTKNQLVLIVNENPASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSSSSSSSGGGGSSSTGTSAITTSLPQLGDLTTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCGGASGGKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSANPLSTLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQLPQSSSGNTIIPSNSGSSPNMNILAAAVTTPSSEKVASSAGASHVSNPAVSSSSSPAFAISSLLSPASNPLLPQQASANSVFPSPLPNIGTTAEDLNSLSALAQQRKSKPPNVTAFEAKSTSDEAFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTSTGIPYGMSIPPEKPVTSWLDTKPVLPTLTTSVGLPLPPTLPSLIPFIKTEEPAPIPISHSATSPPGSVKSDSGGPESATRNLGGLPEEAEGSTLPPSGGKSEESGMVTNSVPTASSSVLSSPAADCGPAGSATTFTNPLLPLMSEQFKAKFPFGGLLDSAQASETSKLQQLVENIDKKATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDENMEDCPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASLKSVENGSIEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKPQRAVPSEFANGLSPTPVNGGALDLTSSHAEKIIKEDSLGILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPSSNLGPNQNSAVIPANSLSSLIKTEVNGFVHVSPQDSKDTPTSHVPSGPLSSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTPARRGRRLSVDGPMTFLGGNPVKFPEMFQKDLAARSGSGDPSSFWNQYAAALSNGLAMKANEISVIQNGGIPPIPGSLGSGNSSPVSGLTGNLERLQNSEPNAPLAGLEKMASSENGTNFRFTRFVEDSKEIVTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	QSDPEVASLPRRDGD CCCHHHHCCCCCCCC	44.04	24719451
28	Phosphorylation	LPRRDGDTEKGQPSR CCCCCCCCCCCCCCC	45.16	-
34	Phosphorylation	DTEKGQPSRPTKSKD CCCCCCCCCCCCCCC	42.90	-
37	O-linked_Glycosylation	KGQPSRPTKSKDAHV CCCCCCCCCCCCCCH	47.00	30379171
152	Phosphorylation	SSTAPSSSSSSSSSS CCCCCCCCCCCCCCC	38.28	-
153	Phosphorylation	STAPSSSSSSSSSSG CCCCCCCCCCCCCCC	35.87	-
154	Phosphorylation	TAPSSSSSSSSSSGG CCCCCCCCCCCCCCC	35.87	-
155	Phosphorylation	APSSSSSSSSSSGGG CCCCCCCCCCCCCCC	35.87	-
266	Phosphorylation	SQNADLPTSSSPSQG HCCCCCCCCCCCCCC	48.84	29978859
267	Phosphorylation	QNADLPTSSSPSQGT CCCCCCCCCCCCCCC	27.21	29978859
268	Phosphorylation	NADLPTSSSPSQGTL CCCCCCCCCCCCCCC	49.06	29978859
269	Phosphorylation	ADLPTSSSPSQGTLR CCCCCCCCCCCCCCC	28.47	29978859
271	Phosphorylation	LPTSSSPSQGTLRTS CCCCCCCCCCCCCCC	43.09	29978859
274	Phosphorylation	SSSPSQGTLRTSANP CCCCCCCCCCCCCCH	12.87	29978859
324	Phosphorylation	PPIQLPQSSSGNTII CCCCCCCCCCCCEEC	25.24	-
337	Phosphorylation	IIPSNSGSSPNMNIL ECCCCCCCCCCCEEE	42.30	-
349	Phosphorylation	NILAAAVTTPSSEKV EEEEEEEECCCHHHH	28.41	-
439	Sumoylation	NVTAFEAKSTSDEAF CCEEEECCCCCHHHH	47.25	28112733
460	Phosphorylation	FCAKVFGSDSALQIH HHHHHHCCCCEEEEE	19.54	23186163
462	Phosphorylation	AKVFGSDSALQIHLR HHHHCCCCEEEEEEE	32.35	23186163
472	Phosphorylation	QIHLRSHTGERPFKC EEEEECCCCCCCEEC	41.82	21857030
478	Methylation	HTGERPFKCNICGNR CCCCCCEECEECCCC	29.11	-
493	Acetylation	FSTKGNLKVHFQRHK CCCCCCEEEEECHHH	37.35	11795001
572	Phosphorylation	SLIPFIKTEEPAPIP HHCCCCCCCCCCCCC	40.54	21406692
581	Phosphorylation	EPAPIPISHSATSPP CCCCCCCCCCCCCCC	13.16	29978859
583	Phosphorylation	APIPISHSATSPPGS CCCCCCCCCCCCCCC	26.84	29978859
585	Phosphorylation	IPISHSATSPPGSVK CCCCCCCCCCCCCCC	44.79	29978859
586	Phosphorylation	PISHSATSPPGSVKS CCCCCCCCCCCCCCC	28.90	21406692
590	Phosphorylation	SATSPPGSVKSDSGG CCCCCCCCCCCCCCC	31.95	29978859
593	Phosphorylation	SPPGSVKSDSGGPES CCCCCCCCCCCCCCH	34.55	21406692
595	Phosphorylation	PGSVKSDSGGPESAT CCCCCCCCCCCCHHC	53.38	29978859
600	Phosphorylation	SDSGGPESATRNLGG CCCCCCCHHCCCCCC	37.77	29978859
602	Phosphorylation	SGGPESATRNLGGLP CCCCCHHCCCCCCCC	29.39	29978859
620	Phosphorylation	EGSTLPPSGGKSEES CCCCCCCCCCCCCCC	59.23	-
673	Sumoylation	MSEQFKAKFPFGGLL HCHHHHHCCCCCCHH	54.91	28112733
690	Sumoylation	AQASETSKLQQLVEN HHHCCHHHHHHHHHH	58.70	28112733
701	Sumoylation	LVENIDKKATDPNEC HHHHHHHCCCCHHCC	53.42	28112733
727	Phosphorylation	ALKMHYRTHTGERPF HHHHHCCCCCCCCCE	19.34	28555341
729	Phosphorylation	KMHYRTHTGERPFKC HHHCCCCCCCCCEEC	39.87	25159151
753	Phosphorylation	KGNLKTHYSVHRAMP CCCCEEEEEECCCCC	20.02	22817900
825	Phosphorylation	FDDLDNFSDENMEDC HHHCCCCCCCCHHHC	50.71	29449344
836	Phosphorylation	MEDCPEGSIPDTPKS HHHCCCCCCCCCCCC	29.32	29449344
840	Phosphorylation	PEGSIPDTPKSADAS CCCCCCCCCCCCCCC	27.54	29449344
843	Phosphorylation	SIPDTPKSADASQDS CCCCCCCCCCCCCCC	32.36	30377224
847	Phosphorylation	TPKSADASQDSLSSS CCCCCCCCCCCCCCC	34.76	30377224
850	Phosphorylation	SADASQDSLSSSPLP CCCCCCCCCCCCCCC	23.63	30377224
852	Phosphorylation	DASQDSLSSSPLPLE CCCCCCCCCCCCCCC	32.49	30377224
853	Phosphorylation	ASQDSLSSSPLPLEM CCCCCCCCCCCCCCH	41.07	30377224
854	Phosphorylation	SQDSLSSSPLPLEMS CCCCCCCCCCCCCHH	27.38	30377224
930	Phosphorylation	TSSMQALSPSNSTQE CCCCCCCCCCCCCCC	29.33	24275569
941	Phosphorylation	STQEFHKSPSIEEKP CCCCHHCCCCHHCCC	18.47	25850435
943	Phosphorylation	QEFHKSPSIEEKPQR CCHHCCCCHHCCCCC	50.12	28112733
947	Sumoylation	KSPSIEEKPQRAVPS CCCCHHCCCCCCCCH	33.39	28112733
954	Phosphorylation	KPQRAVPSEFANGLS CCCCCCCHHHCCCCC	38.45	25002506
961	Phosphorylation	SEFANGLSPTPVNGG HHHCCCCCCCCCCCC	28.29	25002506
963	Phosphorylation	FANGLSPTPVNGGAL HCCCCCCCCCCCCCC	36.17	25002506
973	Phosphorylation	NGGALDLTSSHAEKI CCCCCCCCHHHHHHH	28.05	25002506
974	Phosphorylation	GGALDLTSSHAEKII CCCCCCCHHHHHHHH	27.68	25002506
975	Phosphorylation	GALDLTSSHAEKIIK CCCCCCHHHHHHHHH	22.83	25002506
982	Sumoylation	SHAEKIIKEDSLGIL HHHHHHHHHCCCCEE	59.97	28112733
985	Phosphorylation	EKIIKEDSLGILFPF HHHHHHCCCCEEECC	29.59	21406692
1019	Phosphorylation	CQSALDIHYRSHTKE CCHHHHHHCCCCCCC	16.18	32142685
1083	Phosphorylation	IPANSLSSLIKTEVN EEHHHHHHHHHHEEC	39.13	24719451
1086	Sumoylation	NSLSSLIKTEVNGFV HHHHHHHHHEECCEE	43.88	-
1086	Sumoylation	NSLSSLIKTEVNGFV HHHHHHHHHEECCEE	43.88	12200128
1101	Phosphorylation	HVSPQDSKDTPTSHV EECCCCCCCCCCCCC	74.12	32142685
1103	Phosphorylation	SPQDSKDTPTSHVPS CCCCCCCCCCCCCCC	32.00	25850435
1105	Phosphorylation	QDSKDTPTSHVPSGP CCCCCCCCCCCCCCC	33.29	25850435
1106	Phosphorylation	DSKDTPTSHVPSGPL CCCCCCCCCCCCCCC	24.56	25850435
1107	Phosphorylation	SKDTPTSHVPSGPLS CCCCCCCCCCCCCCC	37.68	32142685
1110	Phosphorylation	TPTSHVPSGPLSSSA CCCCCCCCCCCCCCC	52.53	30266825
1114	Phosphorylation	HVPSGPLSSSATSPV CCCCCCCCCCCCCCC	25.94	30266825
1115	Phosphorylation	VPSGPLSSSATSPVL CCCCCCCCCCCCCCC	31.51	30266825
1116	Phosphorylation	PSGPLSSSATSPVLL CCCCCCCCCCCCCCC	31.99	30266825
1118	Phosphorylation	GPLSSSATSPVLLPA CCCCCCCCCCCCCCC	35.20	30266825
1119	Phosphorylation	PLSSSATSPVLLPAL CCCCCCCCCCCCCCC	16.84	30266825
1135	Phosphorylation	RRTPKQHYCNTCGKT CCCCCCEECCCCCCC	5.72	29116813
1142	Phosphorylation	YCNTCGKTFSSSSAL ECCCCCCCCCCCCCE	17.65	24719451
1144	Phosphorylation	NTCGKTFSSSSALQI CCCCCCCCCCCCEEE	34.24	24719451
1147	Phosphorylation	GKTFSSSSALQIHER CCCCCCCCCEEEEEC	34.64	24719451
1155	Phosphorylation	ALQIHERTHTGEKPF CEEEEECCCCCCCCE	22.32	-
1157	Phosphorylation	QIHERTHTGEKPFAC EEEECCCCCCCCEEE	46.56	-
1198	Phosphorylation	ARRGRRLSVDGPMTF CCCCCCCCCCCCEEE	19.15	30266825
1204	Phosphorylation	LSVDGPMTFLGGNPV CCCCCCEEECCCCCC	20.88	21406692
1219	Sumoylation	KFPEMFQKDLAARSG CCHHHHHHHHHHHCC	43.36	28112733
1299	Sumoylation	APLAGLEKMASSENG CCCCHHHHHHCCCCC	44.82	28112733
1307	Phosphorylation	MASSENGTNFRFTRF HHCCCCCCCEEEEEE	42.64	-
1319	Sumoylation	TRFVEDSKEIVTS-- EEEECCCHHHCCC--	64.88	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SALL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SALL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SALL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERF1_HUMAN	TERF1	physical	11751684
UBC9_HUMAN	UBE2I	physical	12200128
SUMO1_HUMAN	SUMO1	physical	12200128

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 107480: Townes-Brocks syndrome (TBS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.