dbPTM

TERF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TERF1_HUMAN
UniProt AC	P54274
Protein Name	Telomeric repeat-binding factor 1
Gene Name	TERF1
Organism	Homo sapiens (Human).
Sequence Length	439
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
Protein Description	Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways..
Protein Sequence	MAEDVSSAAPSPRGCADGRDADPTEEQMAETERNDEEQFECQELLECQVQVGAPEEEEEEEEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRNSAEAIIHGLSSLTACQLRTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGSIEKEHDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMIISQKDTFHSFFQHFSYNHMMEKIKSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQDKPSGNDVEMETEANLDTRKSVSDKQSAVTESSEGTVSLLRSHKNLFLSKLQHGTQQQDLNKKERRVGTPQSTKKKKESRRATESRIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKFNNRTSVMLKDRWRTMKKLKLISSDSED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEDVSSAA ------CCCCHHHCC	23.00	20068231
6	Phosphorylation	--MAEDVSSAAPSPR --CCCCHHHCCCCCC	26.95	29255136
7	Phosphorylation	-MAEDVSSAAPSPRG -CCCCHHHCCCCCCC	28.44	29255136
11	Phosphorylation	DVSSAAPSPRGCADG CHHHCCCCCCCCCCC	23.62	29255136
24	Phosphorylation	DGRDADPTEEQMAET CCCCCCCCHHHHHHH	53.34	22210691
32	Ubiquitination	EEQMAETERNDEEQF HHHHHHHHCCHHHHH	40.78	22817900
114	Phosphorylation	AIIHGLSSLTACQLR HHHHHHHHCHHHHHH	34.48	22210691
122	Phosphorylation	LTACQLRTIYICQFL CHHHHHHHHHHHHHH	27.07	22817900
136	Ubiquitination	LTRIAAGKTLDAQFE HHHHHCCCCHHHHCC	40.98	21906983
136 (in isoform 2)	Ubiquitination	-	40.98	21890473
136 (in isoform 1)	Ubiquitination	-	40.98	21890473
149	Phosphorylation	FENDERITPLESALM CCCCCCCCHHHHHHH	28.21	-
153	Phosphorylation	ERITPLESALMIWGS CCCCHHHHHHHHHHC	34.09	20860994
160	Phosphorylation	SALMIWGSIEKEHDK HHHHHHHCHHHHHHH	16.75	20860994
167	Ubiquitination	SIEKEHDKLHEEIQN CHHHHHHHHHHHHHH	54.36	29967540
213	Sumoylation	SHMPFKSKLLMIISQ CCCCCCHHEEEHHCC	46.35	28112733
219	Phosphorylation	SKLLMIISQKDTFHS HHEEEHHCCHHHHHH	21.91	28112733
225	Ubiquitination	ISQKDTFHSFFQHFS HCCHHHHHHHHHHCC	26.28	24816145
241	Acetylation	NHMMEKIKSYVNYVL HHHHHHHHHHHHHHH	46.96	164497481
242	Phosphorylation	HMMEKIKSYVNYVLS HHHHHHHHHHHHHHC	37.47	20068231
243	Phosphorylation	MMEKIKSYVNYVLSE HHHHHHHHHHHHHCC	6.42	20068231
249	Phosphorylation	SYVNYVLSEKSSTFL HHHHHHHCCCCHHHH	32.69	20068231
252	Phosphorylation	NYVLSEKSSTFLMKA HHHHCCCCHHHHHHH	30.47	-
253	Phosphorylation	YVLSEKSSTFLMKAA HHHCCCCHHHHHHHH	33.96	-
254	Phosphorylation	VLSEKSSTFLMKAAA HHCCCCHHHHHHHHH	28.07	-
266	Phosphorylation	AAAKVVESKRTRTIT HHHHHHHCCCCEEEC	18.81	-
271	Phosphorylation	VESKRTRTITSQDKP HHCCCCEEECCCCCC	28.17	-
273	Phosphorylation	SKRTRTITSQDKPSG CCCCEEECCCCCCCC	21.52	22817900
287	Ubiquitination	GNDVEMETEANLDTR CCCCCCCEEECCCCC	38.80	21890473
295	Acetylation	EANLDTRKSVSDKQS EECCCCCCCCCHHHH	58.25	18526043
296	Phosphorylation	ANLDTRKSVSDKQSA ECCCCCCCCCHHHHC	24.46	-
299	Ubiquitination	DTRKSVSDKQSAVTE CCCCCCCHHHHCEEC	51.35	29967540
300	Ubiquitination	TRKSVSDKQSAVTES CCCCCCHHHHCEECC	38.35	29967540
300	Acetylation	TRKSVSDKQSAVTES CCCCCCHHHHCEECC	38.35	18526049
305	Phosphorylation	SDKQSAVTESSEGTV CHHHHCEECCCHHHH	29.84	20860994
305	Ubiquitination	SDKQSAVTESSEGTV CHHHHCEECCCHHHH	29.84	29967540
308	Phosphorylation	QSAVTESSEGTVSLL HHCEECCCHHHHHHH	33.54	-
311	Phosphorylation	VTESSEGTVSLLRSH EECCCHHHHHHHHHC	11.67	-
319	Ubiquitination	VSLLRSHKNLFLSKL HHHHHHCCHHHHHHH	57.50	29967540
325	Ubiquitination	HKNLFLSKLQHGTQQ CCHHHHHHHCCCCHH	55.07	29967540
325	Sumoylation	HKNLFLSKLQHGTQQ CCHHHHHHHCCCCHH	55.07	28112733
329	Ubiquitination	FLSKLQHGTQQQDLN HHHHHCCCCHHHHCC	16.56	24816145
330	Phosphorylation	LSKLQHGTQQQDLNK HHHHCCCCHHHHCCH	22.53	23312004
337	Ubiquitination	TQQQDLNKKERRVGT CHHHHCCHHHHCCCC	64.41	21890473
338	Ubiquitination	QQQDLNKKERRVGTP HHHHCCHHHHCCCCC	56.21	-
344	Phosphorylation	KKERRVGTPQSTKKK HHHHCCCCCHHHHHH	18.46	18625707
346	Ubiquitination	ERRVGTPQSTKKKKE HHCCCCCHHHHHHHH	64.67	33845483
347	Phosphorylation	RRVGTPQSTKKKKES HCCCCCHHHHHHHHH	43.32	-
349	Ubiquitination	VGTPQSTKKKKESRR CCCCHHHHHHHHHHH	68.77	24816145
358	Phosphorylation	KKESRRATESRIPVS HHHHHHCCCCCCCCC	32.45	28555341
365	Phosphorylation	TESRIPVSKSQPVTP CCCCCCCCCCCCCCH	22.64	21712546
366	Sumoylation	ESRIPVSKSQPVTPE CCCCCCCCCCCCCHH	54.03	28112733
366	Ubiquitination	ESRIPVSKSQPVTPE CCCCCCCCCCCCCHH	54.03	33845483
367	Phosphorylation	SRIPVSKSQPVTPEK CCCCCCCCCCCCHHH	32.01	30266825
371	Phosphorylation	VSKSQPVTPEKHRAR CCCCCCCCHHHHHHH	32.20	30266825
377	Ubiquitination	VTPEKHRARKRQAWL CCHHHHHHHHHHHHH	22.52	29967540
391	Ubiquitination	LWEEDKNLRSGVRKY HHHHCCCHHHHCHHH	5.93	21890473
391 (in isoform 2)	Ubiquitination	-	5.93	21890473
397	Ubiquitination	NLRSGVRKYGEGNWS CHHHHCHHHCCCCCE	56.02	29967540
398	Phosphorylation	LRSGVRKYGEGNWSK HHHHCHHHCCCCCEE	15.17	30177828
404	Phosphorylation	KYGEGNWSKILLHYK HHCCCCCEEEEEEEE	17.51	30177828
410	Phosphorylation	WSKILLHYKFNNRTS CEEEEEEEEECCCCC	19.76	27174698
411	Ubiquitination	SKILLHYKFNNRTSV EEEEEEEEECCCCCE	30.76	22817900
411 (in isoform 1)	Ubiquitination	-	30.76	21890473
415	Phosphorylation	LHYKFNNRTSVMLKD EEEEECCCCCEEEHH	29.49	33259812
416	Phosphorylation	HYKFNNRTSVMLKDR EEEECCCCCEEEHHH	28.00	27174698
417	Phosphorylation	YKFNNRTSVMLKDRW EEECCCCCEEEHHHH	11.42	18669648
421	Ubiquitination	NRTSVMLKDRWRTMK CCCCEEEHHHHHHHH	27.44	21890473
434	Phosphorylation	MKKLKLISSDSED-- HHHHHCCCCCCCC--	38.23	28450419
435	Phosphorylation	KKLKLISSDSED--- HHHHCCCCCCCC---	37.86	18625707
437	Phosphorylation	LKLISSDSED----- HHCCCCCCCC-----	45.68	28450419
441	Ubiquitination	SSDSED--------- CCCCCC---------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
114	S	Phosphorylation	Kinase	NEK2	P51955	PSP
114	S	Phosphorylation	Kinase	NEK7	Q8TDX7	PSP
122	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
122	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
122	T	Phosphorylation	Kinase	CSNK2B	-	GPS
219	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
273	T	Phosphorylation	Kinase	AKT1	P31749	PSP
344	T	Phosphorylation	Kinase	CDK1	P06493	PSP
367	S	Phosphorylation	Kinase	ATM	Q13315	PSP
371	T	Phosphorylation	Kinase	CDK1	P06493	PSP
435	S	Phosphorylation	Kinase	PLK1	P53350	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO4	Q9UKT5	PMID:20181953
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:31801865

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
219	S	Phosphorylation		11375976
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TERF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNS1_HUMAN	CAPNS1	physical	16169070
DLG5_HUMAN	DLG5	physical	16169070
RIC8A_HUMAN	RIC8A	physical	16169070
SH3G3_HUMAN	SH3GL3	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
TINF2_HUMAN	TINF2	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
PROF2_HUMAN	PFN2	physical	16169070
ZHX1_HUMAN	ZHX1	physical	16169070
TNKS1_HUMAN	TNKS	physical	11739745
TNKS1_HUMAN	TNKS	physical	11854288
TNKS1_HUMAN	TNKS	physical	12080061
TERF1_HUMAN	TERF1	physical	9130722
ATM_HUMAN	ATM	physical	11375976
ABL1_HUMAN	ABL1	physical	11375976
SALL1_HUMAN	SALL1	physical	11751684
NDKA_HUMAN	NME1	physical	9480811
TINF2_HUMAN	TINF2	physical	10581025
PINX1_HUMAN	PINX1	physical	11701125
TNKS2_HUMAN	TNKS2	physical	10988299
IMB1_HUMAN	KPNB1	physical	12135354
TNKS1_HUMAN	TNKS	physical	9822378
MARE1_HUMAN	MAPRE1	genetic	11943150
TNKS1_HUMAN	TNKS	physical	11802774
TNKS2_HUMAN	TNKS2	physical	11802774
CDC6_HUMAN	CDC6	physical	18761675
FBX4_HUMAN	FBXO4	physical	16275645
BRCA1_HUMAN	BRCA1	physical	19797051
FBX4_HUMAN	FBXO4	physical	20159592
TINF2_HUMAN	TINF2	physical	20811636
ZCCHL_HUMAN	ZC3HAV1L	physical	20811636
RB15B_HUMAN	RBM15B	physical	20811636
POTE1_HUMAN	POT1	physical	20811636
IMA1_HUMAN	KPNA2	physical	20811636
TERF1_HUMAN	TERF1	physical	20811636
CHIP_HUMAN	STUB1	physical	20811636
TYY1_HUMAN	YY1	physical	20811636
RBM33_HUMAN	RBM33	physical	20811636
PABP4_HUMAN	PABPC4	physical	20811636
MCCB_HUMAN	MCCC2	physical	20811636
CSK2B_HUMAN	CSNK2B	physical	20811636
BMP2K_HUMAN	BMP2K	physical	20811636
CYFP1_HUMAN	CYFIP1	physical	20811636
S10A8_HUMAN	S100A8	physical	20811636
HSP74_HUMAN	HSPA4	physical	20811636
ACTN1_HUMAN	ACTN1	physical	20811636
MCM7_HUMAN	MCM7	physical	20811636
DDB1_HUMAN	DDB1	physical	20811636
PRDX4_HUMAN	PRDX4	physical	20811636
RGF1C_HUMAN	RASGEF1C	physical	20811636
CDK9_HUMAN	CDK9	physical	20811636
FBX21_HUMAN	FBXO21	physical	20811636
BI2L1_HUMAN	BAIAP2L1	physical	20811636
CHD8_HUMAN	CHD8	physical	20811636
TOX4_HUMAN	TOX4	physical	20811636
CLK3_HUMAN	CLK3	physical	20811636
SC16A_HUMAN	SEC16A	physical	20811636
S10A7_HUMAN	S100A7	physical	20811636
IMB1_HUMAN	KPNB1	physical	20811636
USP9X_HUMAN	USP9X	physical	20811636
RS2_HUMAN	RPS2	physical	20811636
CSK22_HUMAN	CSNK2A2	physical	20811636
PLOD2_HUMAN	PLOD2	physical	20811636
RING1_HUMAN	RING1	physical	20811636
ZN281_HUMAN	ZNF281	physical	20811636
FOXJ3_HUMAN	FOXJ3	physical	20811636
LARP7_HUMAN	LARP7	physical	20811636
IRS4_HUMAN	IRS4	physical	20811636
S30BP_HUMAN	SAP30BP	physical	20811636
DYST_HUMAN	DST	physical	20811636
XRCC5_HUMAN	XRCC5	physical	20811636
ENPL_HUMAN	HSP90B1	physical	20811636
ACLY_HUMAN	ACLY	physical	20811636
PRPS3_HUMAN	PRPS1L1	physical	20811636
IDH3A_HUMAN	IDH3A	physical	20811636
HS105_HUMAN	HSPH1	physical	20811636
SPTN1_HUMAN	SPTAN1	physical	20811636
MACD2_HUMAN	MACROD2	physical	20811636
BAG3_HUMAN	BAG3	physical	20811636
TNKS1_HUMAN	TNKS	physical	20811636
CCNT1_HUMAN	CCNT1	physical	20811636
MYH9_HUMAN	MYH9	physical	20811636
TBPL1_HUMAN	TBPL1	physical	20811636
RS8_HUMAN	RPS8	physical	20811636
KCD15_HUMAN	KCTD15	physical	20811636
PLOD1_HUMAN	PLOD1	physical	20811636
TBX1_HUMAN	TBX1	physical	20811636
RSBNL_HUMAN	RSBN1L	physical	20811636
RAD50_HUMAN	RAD50	physical	20811636
TRPC5_HUMAN	TRPC5	physical	20811636
CFA58_HUMAN	CFAP58	physical	20811636
T2AG_HUMAN	GTF2A2	physical	20811636
PIMT_HUMAN	PCMT1	physical	20811636
RS7_HUMAN	RPS7	physical	20811636
PSB5_HUMAN	PSMB5	physical	20811636
GRPE1_HUMAN	GRPEL1	physical	20811636
PSA7_HUMAN	PSMA7	physical	20811636
PSA2_HUMAN	PSMA2	physical	20811636
PP2AA_HUMAN	PPP2CA	physical	20811636
PP2AB_HUMAN	PPP2CB	physical	20811636
GANAB_HUMAN	GANAB	physical	20811636
ANM5_HUMAN	PRMT5	physical	20811636
NEXMI_HUMAN	KIAA2022	physical	20811636
TDRD6_HUMAN	TDRD6	physical	20811636
DOCK2_HUMAN	DOCK2	physical	20811636
SYNE2_HUMAN	SYNE2	physical	20811636
CENPF_HUMAN	CENPF	physical	20811636
RS16_HUMAN	RPS16	physical	20811636
TAF2_HUMAN	TAF2	physical	20811636
RYR2_HUMAN	RYR2	physical	20811636
RING2_HUMAN	RNF2	physical	20811636
ATN1_HUMAN	ATN1	physical	20811636
CDC37_HUMAN	CDC37	physical	20811636
ARHGI_HUMAN	ARHGEF18	physical	20811636
CDK13_HUMAN	CDK13	physical	20811636
BRE1B_HUMAN	RNF40	physical	20811636
UTRO_HUMAN	UTRN	physical	20811636
DMD_HUMAN	DMD	physical	20811636
RGPA1_HUMAN	RALGAPA1	physical	20811636
GNL3_HUMAN	GNL3	physical	17000763
FBX4_HUMAN	FBXO4	physical	20181953
SKP1_HUMAN	SKP1	physical	20181953
GNL3_HUMAN	GNL3	physical	19487455
GNL3L_HUMAN	GNL3L	physical	19487455
TERF1_HUMAN	TERF1	physical	19487455
TINF2_HUMAN	TINF2	physical	19487455
TERT_HUMAN	TERT	physical	19487455
FBX4_HUMAN	FBXO4	physical	19487455
TERF2_HUMAN	TERF2	physical	15316005
TE2IP_HUMAN	TERF2IP	physical	15316005
TINF2_HUMAN	TINF2	physical	15316005
PRKDC_HUMAN	PRKDC	physical	18160036
MTOR_HUMAN	MTOR	physical	18160036
TNKS1_HUMAN	TNKS	physical	22645305
ORF73_HHV8P	HHV8GK18_gp81	physical	22379092
RYDEN_HUMAN	C19orf66	physical	21044950
NP1L1_HUMAN	NAP1L1	physical	21044950
WFS1_HUMAN	WFS1	physical	21044950
CASP7_HUMAN	CASP7	physical	21044950
RPAP3_HUMAN	RPAP3	physical	21044950
PEPD_HUMAN	PEPD	physical	21044950
THIC_HUMAN	ACAT2	physical	21044950
MOES_HUMAN	MSN	physical	21044950
PRDX1_HUMAN	PRDX1	physical	21044950
SPT5H_HUMAN	SUPT5H	physical	21044950
RBY1A_HUMAN	RBMY1A1	physical	21044950
RNF10_HUMAN	RNF10	physical	21044950
LRSM1_HUMAN	LRSAM1	physical	21044950
TRM1_HUMAN	TRMT1	physical	21044950
PINX1_HUMAN	PINX1	physical	21044950
SOAT1_HUMAN	SOAT1	physical	21044950
JSPR1_HUMAN	JSRP1	physical	21044950
CL043_HUMAN	C12orf43	physical	21044950
6PGD_HUMAN	PGD	physical	21044950
HSP76_HUMAN	HSPA6	physical	21044950
TNPO2_HUMAN	TNPO2	physical	21044950
TBB3_HUMAN	TUBB3	physical	21044950
TKT_HUMAN	TKT	physical	21044950
PA2G4_HUMAN	PA2G4	physical	21044950
KEAP1_HUMAN	KEAP1	physical	21044950
RTN3_HUMAN	RTN3	physical	21044950
AMPH_HUMAN	AMPH	physical	21044950
HGD_HUMAN	HGD	physical	21044950
PUR6_HUMAN	PAICS	physical	21044950
NOL12_HUMAN	NOL12	physical	21044950
RL19_HUMAN	RPL19	physical	21044950
SYWC_HUMAN	WARS	physical	21044950
MMTA2_HUMAN	C1orf35	physical	21044950
ALDOA_HUMAN	ALDOA	physical	21044950
SH3G2_HUMAN	SH3GL2	physical	21044950
KLDC4_HUMAN	KLHDC4	physical	21044950
KBP_HUMAN	KIAA1279	physical	21044950
CEP85_HUMAN	CEP85	physical	21044950
SIRPD_HUMAN	SIRPD	physical	21044950
GSHB_HUMAN	GSS	physical	21044950
THG1_HUMAN	THG1L	physical	21044950
KSYK_HUMAN	SYK	physical	21044950
MK12_HUMAN	MAPK12	physical	21044950
NFL_HUMAN	NEFL	physical	21044950
PTN5_HUMAN	PTPN5	physical	21044950
COR1B_HUMAN	CORO1B	physical	21044950
CRYM_HUMAN	CRYM	physical	21044950
DNJB1_HUMAN	DNAJB1	physical	21044950
SPEE_HUMAN	SRM	physical	21044950
HCLS1_HUMAN	HCLS1	physical	21044950
HYES_HUMAN	EPHX2	physical	21044950
FKBP8_HUMAN	FKBP8	physical	21044950
FEN1_HUMAN	FEN1	physical	21044950
MDHC_HUMAN	MDH1	physical	21044950
LDHB_HUMAN	LDHB	physical	21044950
MAP4_HUMAN	MAP4	physical	21044950
MAP7_HUMAN	MAP7	physical	21044950
PRDX6_HUMAN	PRDX6	physical	21044950
ASSY_HUMAN	ASS1	physical	21044950
AMPD2_HUMAN	AMPD2	physical	21044950
SMRC2_HUMAN	SMARCC2	physical	21044950
WDR4_HUMAN	WDR4	physical	21044950
KPYM_HUMAN	PKM	physical	21044950
RTN4_HUMAN	RTN4	physical	21044950
PAK4_HUMAN	PAK4	physical	21044950
CRBB1_HUMAN	CRYBB1	physical	21044950
3BP1_HUMAN	SH3BP1	physical	21044950
MCM2_HUMAN	MCM2	physical	21044950
TPIS_HUMAN	TPI1	physical	21044950
DDX23_HUMAN	DDX23	physical	21044950
E41L1_HUMAN	EPB41L1	physical	21044950
PNMT_HUMAN	PNMT	physical	21044950
F16P1_HUMAN	FBP1	physical	21044950
PA1B3_HUMAN	PAFAH1B3	physical	21044950
DNPH1_HUMAN	DNPH1	physical	21044950
EVL_HUMAN	EVL	physical	21044950
TERF1_HUMAN	TERF1	physical	21044950
DD19B_HUMAN	DDX19B	physical	21044950
AK1A1_HUMAN	AKR1A1	physical	21044950
LYAR_HUMAN	LYAR	physical	21044950
KPCB_HUMAN	PRKCB	physical	21044950
ANXA2_HUMAN	ANXA2	physical	21044950
TBL1X_HUMAN	TBL1X	physical	21044950
COF1_HUMAN	CFL1	physical	21044950
DDX21_HUMAN	DDX21	physical	21044950
HDGR2_HUMAN	HDGFRP2	physical	21044950
SAHH_HUMAN	AHCY	physical	21044950
NUD14_HUMAN	NUDT14	physical	21044950
CHIP_HUMAN	STUB1	physical	21044950
ACY1_HUMAN	ACY1	physical	21044950
ZCH18_HUMAN	ZC3H18	physical	21044950
FES_HUMAN	FES	physical	21044950
ARP21_HUMAN	ARPP21	physical	21044950
HEXI1_HUMAN	HEXIM1	physical	21044950
HMOX1_HUMAN	HMOX1	physical	21044950
HEXI2_HUMAN	HEXIM2	physical	21044950
H11_HUMAN	HIST1H1A	physical	21044950
OGFR_HUMAN	OGFR	physical	21044950
KIME_HUMAN	MVK	physical	21044950
BCL7B_HUMAN	BCL7B	physical	21044950
SRSF6_HUMAN	SRSF6	physical	21044950
SET_HUMAN	SET	physical	21044950
TINF2_HUMAN	TINF2	physical	21044950
PTMA_HUMAN	PTMA	physical	21044950
PACN2_HUMAN	PACSIN2	physical	21044950
TALDO_HUMAN	TALDO1	physical	21044950
CALD1_HUMAN	CALD1	physical	21044950
TBB2A_HUMAN	TUBB2A	physical	21044950
IPO5_HUMAN	IPO5	physical	21044950
APEX1_HUMAN	APEX1	physical	21044950
DPYL3_HUMAN	DPYSL3	physical	21044950
SYSC_HUMAN	SARS	physical	21044950
DDX24_HUMAN	DDX24	physical	21044950
6PGL_HUMAN	PGLS	physical	21044950
GAMT_HUMAN	GAMT	physical	21044950
TBCD_HUMAN	TBCD	physical	21044950
HXA3_HUMAN	HOXA3	physical	21044950
HNMT_HUMAN	HNMT	physical	21044950
1433G_HUMAN	YWHAG	physical	21044950
OCM2_HUMAN	OCM2	physical	21044950
BACH_HUMAN	ACOT7	physical	21044950
BIN2_HUMAN	BIN2	physical	21044950
EF1D_HUMAN	EEF1D	physical	21044950
GDIR1_HUMAN	ARHGDIA	physical	21044950
PPM1G_HUMAN	PPM1G	physical	21044950
HMGN4_HUMAN	HMGN4	physical	21044950
SYUG_HUMAN	SNCG	physical	21044950
TB10A_HUMAN	TBC1D10A	physical	21044950
CIP4_HUMAN	TRIP10	physical	21044950
SP100_HUMAN	SP100	physical	21044950
NUMA1_HUMAN	NUMA1	physical	21044950
TYB4Y_HUMAN	TMSB4Y	physical	21044950
MT1X_HUMAN	MT1X	physical	21044950
KAD1_HUMAN	AK1	physical	21044950
CCDC9_HUMAN	CCDC9	physical	21044950
HMGN3_HUMAN	HMGN3	physical	21044950
DX39A_HUMAN	DDX39A	physical	21044950
PCP4_HUMAN	PCP4	physical	21044950
HS90B_HUMAN	HSP90AB1	physical	21044950
RECQ4_HUMAN	RECQL4	physical	21044950
ZN790_HUMAN	ZNF790	physical	21044950
DPP3_HUMAN	DPP3	physical	21044950
IF4B_HUMAN	EIF4B	physical	21044950
DREB_HUMAN	DBN1	physical	21044950
TBB4B_HUMAN	TUBB4B	physical	21044950
DCX_HUMAN	DCX	physical	21044950
ANXA5_HUMAN	ANXA5	physical	21044950
DBNL_HUMAN	DBNL	physical	21044950
PGM1_HUMAN	PGM1	physical	21044950
NOL3_HUMAN	NOL3	physical	21044950
ST1C2_HUMAN	SULT1C2	physical	21044950
ENOG_HUMAN	ENO2	physical	21044950
AXA81_HUMAN	ANXA8L1	physical	21044950
LDHA_HUMAN	LDHA	physical	21044950
TRI16_HUMAN	TRIM16	physical	21044950
TOM34_HUMAN	TOMM34	physical	21044950
PGM2_HUMAN	PGM2	physical	21044950
LASP1_HUMAN	LASP1	physical	21044950
PFKAP_HUMAN	PFKP	physical	21044950
KCRB_HUMAN	CKB	physical	21044950
TISB_HUMAN	ZFP36L1	physical	21044950
NUDC2_HUMAN	NUDCD2	physical	21044950
PAGE2_HUMAN	PAGE2	physical	21044950
TYB10_HUMAN	TMSB10	physical	21044950
SBDS_HUMAN	SBDS	physical	21044950
NXNL1_HUMAN	NXNL1	physical	21044950
G3P_HUMAN	GAPDH	physical	21044950
CPNE3_HUMAN	CPNE3	physical	21044950
AF1L2_HUMAN	AFAP1L2	physical	21044950
GNMT_HUMAN	GNMT	physical	21044950
RNF12_HUMAN	RLIM	physical	19164295
PINX1_HUMAN	PINX1	physical	19164295
TNKS2_HUMAN	TNKS2	physical	11454873
FBW1A_HUMAN	BTRC	physical	23583392
TNKS1_HUMAN	TNKS	physical	23583392
TINF2_HUMAN	TINF2	physical	15133513
TNKS1_HUMAN	TNKS	physical	15133513
KDM1A_HUMAN	KDM1A	physical	23455924
U2AF2_HUMAN	U2AF2	physical	24389012
U2AF1_HUMAN	U2AF1	physical	24389012
FBX4_HUMAN	FBXO4	physical	24389012
EP300_HUMAN	EP300	physical	23307557
POTE1_HUMAN	POT1	physical	26186194
TINF2_HUMAN	TINF2	physical	26186194
TNKS2_HUMAN	TNKS2	physical	26186194
TNKS1_HUMAN	TNKS	physical	26186194
TE2IP_HUMAN	TERF2IP	physical	26186194
ACD_HUMAN	ACD	physical	26186194
FOXM1_HUMAN	FOXM1	physical	26496610
XPO1_HUMAN	XPO1	physical	26496610
TNKS1_HUMAN	TNKS	physical	26496610
POTE1_HUMAN	POT1	physical	26496610
TE2IP_HUMAN	TERF2IP	physical	26496610
RT09_HUMAN	MRPS9	physical	26496610
ACD_HUMAN	ACD	physical	26496610
BRWD3_HUMAN	BRWD3	physical	26496610
NUB1_HUMAN	NUB1	physical	27214791
PINX1_HUMAN	PINX1	physical	27214791
PSMD4_HUMAN	PSMD4	physical	27214791
TINF2_HUMAN	TINF2	physical	28514442
POTE1_HUMAN	POT1	physical	28514442
ACD_HUMAN	ACD	physical	28514442
TNKS1_HUMAN	TNKS	physical	28514442
TNKS2_HUMAN	TNKS2	physical	28514442
TERF1_HUMAN	TERF1	physical	24895130
NEK7_HUMAN	NEK7	physical	28216227
FBX4_HUMAN	FBXO4	physical	28216227

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TERF1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-11, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-11, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434; SER-435 ANDSER-437, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Telomeric protein Pin2/TRF1 as an important ATM target in response todouble strand DNA breaks."; Kishi S., Zhou X.Z., Ziv Y., Khoo C., Hill D.E., Shiloh Y., Lu K.P.; J. Biol. Chem. 276:29282-29291(2001). Cited for: MUTAGENESIS OF SER-219, PHOSPHORYLATION AT SER-219, AND INTERACTIONWITH ATM.	11375976 [Abstract]

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