HXA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXA3_HUMAN
• UniProt AC: O43365
• Protein Name: Homeobox protein Hox-A3
• Gene Name: HOXA3
• Organism: Homo sapiens (Human).
• Sequence Length: 443
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPTYTDLTGHHPSQGRIQEAPKLTHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Phosphorylation	TPANAAKSPLLNSPT CCCHHHCCCCCCCHH	18.96	20363803
148	Phosphorylation	AKSPLLNSPTVAKQI HCCCCCCCHHHHHHH	23.16	25159151
150	Phosphorylation	SPLLNSPTVAKQIFP CCCCCCHHHHHHHHH	32.68	25850435
170	Phosphorylation	RQNTKQKTSSSSSGE HHCCCCCCCCCCCCC	31.20	28985074
171	Phosphorylation	QNTKQKTSSSSSGES HCCCCCCCCCCCCCC	34.95	30576142
178	Phosphorylation	SSSSSGESCAGDKSP CCCCCCCCCCCCCCC	16.88	30576142
184	Phosphorylation	ESCAGDKSPPGQASS CCCCCCCCCCCCCCC	40.86	30576142
196	Phosphorylation	ASSKRARTAYTSAQL CCCHHHHHHHHHHHH	24.03	-
257	Phosphorylation	QKGKGMLTSSGGQSP CCCCCCCCCCCCCCC	16.38	27794612
258	Phosphorylation	KGKGMLTSSGGQSPS CCCCCCCCCCCCCCC	24.03	27794612
259	Phosphorylation	GKGMLTSSGGQSPSR CCCCCCCCCCCCCCC	41.53	29255136
263	Phosphorylation	LTSSGGQSPSRSPVP CCCCCCCCCCCCCCC	28.28	29255136
265	Phosphorylation	SSGGQSPSRSPVPPG CCCCCCCCCCCCCCC	51.11	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PWP1_HUMAN	PWP1	physical	20211142
ALX4_HUMAN	ALX4	physical	20211142
ARPC3_HUMAN	ARPC3	physical	25416956
SC23B_HUMAN	SEC23B	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.