CRBB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRBB1_HUMAN
• UniProt AC: P53674
• Protein Name: Beta-crystallin B1
• Gene Name: CRYBB1
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: MSQAAKASASATVAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLRDKQWHLEGSFPVLATEPPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSQAAKASA ------CCHHHHHCC	28.64	8626774
6	Acetylation	--MSQAAKASASATV --CCHHHHHCCCCEE	45.98	12060738
10	Phosphorylation	QAAKASASATVAVNP HHHHHCCCCEEEECC	23.21	22817900
12	Phosphorylation	AKASASATVAVNPGP HHHCCCCEEEECCCC	13.40	22817900
107	Phosphorylation	PWVAFEQSNFRGEMF CEEEEECCCCCCEEE	30.64	24719451
130	Phosphorylation	RWNTWSSSYRSDRLM CCCCCCCCCCCCCEE	21.03	22964224
131	Phosphorylation	WNTWSSSYRSDRLMS CCCCCCCCCCCCEEE	18.98	22964224
138	Phosphorylation	YRSDRLMSFRPIKMD CCCCCEEEECEECCC	23.77	24719451
160	Acetylation	LFEGANFKGNTIEIQ EEECCCCCCCEEEEE	51.57	12060738
163	Phosphorylation	GANFKGNTIEIQGDD CCCCCCCEEEEECCC	28.76	-
230	Methylation	QPQMQSLRRLRDKQW HHHHHHHHHHHHCCC	40.61	-
231	Methylation	PQMQSLRRLRDKQWH HHHHHHHHHHHCCCC	39.09	-
235	Methylation	SLRRLRDKQWHLEGS HHHHHHHCCCCCCCC	49.18	12060738

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRBB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRBB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRBB1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CRBB1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 611544: Cataract 17, multiple types (CTRCT17)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND THR-12,ACETYLATION AT LYS-6 AND LYS-160, METHYLATION AT ARG-230; ARG-231 ANDLYS-235, SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738

Methylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND THR-12,ACETYLATION AT LYS-6 AND LYS-160, METHYLATION AT ARG-230; ARG-231 ANDLYS-235, SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738

Phosphorylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND THR-12,ACETYLATION AT LYS-6 AND LYS-160, METHYLATION AT ARG-230; ARG-231 ANDLYS-235, SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738