JSPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JSPR1_HUMAN
• UniProt AC: Q96MG2
• Protein Name: Junctional sarcoplasmic reticulum protein 1
• Gene Name: JSRP1
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Subcellular Localization: Sarcoplasmic reticulum membrane. Endoplasmic reticulum membrane. Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes..
• Protein Description: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity..
• Protein Sequence: MSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	ATPRLADSGSVPHDS CCCCCCCCCCCCCCC	27.62	22673903
46	Phosphorylation	PRLADSGSVPHDSQV CCCCCCCCCCCCCCC	36.11	26437602
51	Phosphorylation	SGSVPHDSQVAEGPS CCCCCCCCCCCCCCC	24.42	26437602
132	Phosphorylation	NKCLVLASLVALLGS HHHHHHHHHHHHHHH	21.15	28842319
139	Phosphorylation	SLVALLGSAFQLCRD HHHHHHHHHHHHHHH	26.36	28842319
166	Phosphorylation	PEPWVPPSSAPREPS CCCCCCCCCCCCCCC	32.82	26437602
167	Phosphorylation	EPWVPPSSAPREPSS CCCCCCCCCCCCCCC	48.33	-
173	Phosphorylation	SSAPREPSSPLPKFE CCCCCCCCCCCCCCC	39.57	26657352
174	Phosphorylation	SAPREPSSPLPKFEA CCCCCCCCCCCCCCC	40.97	26437602
178	Ubiquitination	EPSSPLPKFEAQAPP CCCCCCCCCCCCCCC	64.62	-
186	Phosphorylation	FEAQAPPSAPPAPRA CCCCCCCCCCCCCCC	52.96	-
204	Phosphorylation	VRPKIPGSREAAEND CCCCCCCCHHHHHCC	22.92	26437602
302	Acetylation	SRDAEPRKKQAWVSP CCCCCHHHCCCCCCC	61.01	7692215
320	Phosphorylation	DEEQRPGSRQKLRAG CCHHCCCHHHHHHCC	33.93	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JSPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JSPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JSPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AHNK2_HUMAN	AHNAK2	physical	26186194
AHNK_HUMAN	AHNAK	physical	26186194
GNAO_HUMAN	GNAO1	physical	26186194
YES_HUMAN	YES1	physical	26186194
KPCA_HUMAN	PRKCA	physical	26186194
RRAS_HUMAN	RRAS	physical	26186194
SIAH1_HUMAN	SIAH1	physical	26186194
SIAH1_HUMAN	SIAH1	physical	28514442
AHNK_HUMAN	AHNAK	physical	28514442
AHNK2_HUMAN	AHNAK2	physical	28514442
GNAO_HUMAN	GNAO1	physical	28514442
RRAS_HUMAN	RRAS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.