| UniProt ID | TBX1_HUMAN | |
|---|---|---|
| UniProt AC | O43435 | |
| Protein Name | T-box transcription factor TBX1 | |
| Gene Name | TBX1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 398 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).. | |
| Protein Sequence | MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFARSRNPVASPTQPSGTEKGGHVLKDKEVKAETSRNTPEREVELLRDAGGCVNLGLPCPAECQPFNTQGLVAGRTAGDRLC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 142 | Phosphorylation | AGRRMFPTFQVKLFG CCCCCCCEEEEEECC | 18.55 | - | |
| 202 | Ubiquitination | YHPDSPAKGAQWMKQ ECCCCCCCCHHHHHH | 59.15 | - | |
| 237 | Phosphorylation | ILNSMHRYQPRFHVV EECCCHHCCCCEEEE | 14.27 | - | |
| 255 | Phosphorylation | PRKDSEKYAEENFKT CCCCHHHHHHHHHEE | 18.39 | - | |
| 276 | Phosphorylation | RFTAVTAYQNHRITQ CCEEEEEEECCCCEE | 10.65 | - | |
| 282 | Phosphorylation | AYQNHRITQLKIASN EEECCCCEEEEEECC | 28.01 | - | |
| 327 | Phosphorylation | RSRNPVASPTQPSGT HCCCCCCCCCCCCCC | 28.81 | 29396449 | |
| 327 (in isoform 3) | Phosphorylation | - | 28.81 | 28387310 | |
| 329 | Phosphorylation | RNPVASPTQPSGTEK CCCCCCCCCCCCCCC | 51.09 | 23186163 | |
| 350 | Phosphorylation | DKEVKAETSRNTPER CCCCCCCCCCCCCHH | 37.53 | 29083192 | |
| 351 | Phosphorylation | KEVKAETSRNTPERE CCCCCCCCCCCCHHH | 18.29 | 29083192 | |
| 370 (in isoform 3) | Phosphorylation | - | 32.25 | 26055452 | |
| 372 (in isoform 3) | Phosphorylation | - | 23.52 | 27732954 | |
| 394 (in isoform 3) | Phosphorylation | - | 21.69 | 26055452 | |
| 401 (in isoform 3) | Methylation | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBX1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBX1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBX1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TBX1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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