RBY1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBY1A_HUMAN
• UniProt AC: P0DJD3
• Protein Name: RNA-binding motif protein, Y chromosome, family 1 member A1
• Gene Name: RBMY1A1
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Nucleus .
• Protein Description: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs..
• Protein Sequence: MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Acetylation	ISEVLLIKDRTSKSR HHEEEEEECCCCCCC	40.92	-
72	Phosphorylation	AKDMNGKSLHGKAIK HHHCCCCCCCCCEEE	27.31	24719451
104	Phosphorylation	PASSRNRSPSGSLRS CCCCCCCCCCCCCCC	27.28	25072903
106	Phosphorylation	SSRNRSPSGSLRSAR CCCCCCCCCCCCCCC	42.11	25072903
108	Phosphorylation	RNRSPSGSLRSARGS CCCCCCCCCCCCCCC	25.58	21815630
111	Phosphorylation	SPSGSLRSARGSRGG CCCCCCCCCCCCCCC	27.84	25072903
115	Phosphorylation	SLRSARGSRGGTRGW CCCCCCCCCCCCCCC	23.38	29449344
125	Phosphorylation	GTRGWLPSHEGHLDD CCCCCCCCCCCCCCC	31.81	25072903
135	Phosphorylation	GHLDDGGYTPDLKMS CCCCCCCCCCCCCEE	22.19	25072903
136	Phosphorylation	HLDDGGYTPDLKMSY CCCCCCCCCCCCEEE	17.38	25072903
155	Phosphorylation	IPVKRGPSSRSGGPP EEECCCCCCCCCCCC	41.00	28348404
156	Phosphorylation	PVKRGPSSRSGGPPP EECCCCCCCCCCCCC	33.33	28348404
158	Phosphorylation	KRGPSSRSGGPPPKK CCCCCCCCCCCCCCC	50.48	28348404
174	Phosphorylation	APSAVARSNSWMGSQ CCCHHHHCCCCCCCC	26.02	25072903
176	Phosphorylation	SAVARSNSWMGSQGP CHHHHCCCCCCCCCC	21.49	25072903
180	Phosphorylation	RSNSWMGSQGPMSQR HCCCCCCCCCCCHHH	18.83	25072903
299	Phosphorylation	GYRNRRSSRETREYA HCCCCCCCCCCHHCC	32.12	-
342	Phosphorylation	SSRETRDYAPPHRDY CCCCCCCCCCCCCCC	20.09	-
351	Phosphorylation	PPHRDYAYRDYGHSS CCCCCCCCCCCCCCC	9.59	-
363	Phosphorylation	HSSWDEHSSRGYSYH CCCCCCCCCCCCCCC	21.49	-
364	Phosphorylation	SSWDEHSSRGYSYHD CCCCCCCCCCCCCCC	31.47	-
368	Phosphorylation	EHSSRGYSYHDGYGE CCCCCCCCCCCCCHH	20.86	22210691
373	Phosphorylation	GYSYHDGYGEALGRD CCCCCCCCHHHHCCC	20.18	22210691
389	Phosphorylation	SEHLSGSSYRDALQR CHHCCCCHHHHHHHH	27.93	22210691
428	Phosphorylation	YSNTRDRYGRSWESY ECCCCCCCCCCCHHH	22.60	-
435	Phosphorylation	YGRSWESYSSCGDFH CCCCCHHHCCCCCCC	7.96	-
437	Phosphorylation	RSWESYSSCGDFHYC CCCHHHCCCCCCCCC	17.56	-
443	Phosphorylation	SSCGDFHYCDREHVC CCCCCCCCCCHHHHH	8.95	-
459	Phosphorylation	KDQRNPPSLGRVLPD CCCCCCCCCCCCCCC	44.72	27499020
473	Phosphorylation	DPREACGSSSYVASI CHHHHCCCCCEEEEE	18.92	25072903
474	Phosphorylation	PREACGSSSYVASIV HHHHCCCCCEEEEEE	15.80	25072903
475	Phosphorylation	REACGSSSYVASIVD HHHCCCCCEEEEEEC	25.89	25072903
479	Phosphorylation	GSSSYVASIVDGGES CCCCEEEEEECCCCC	17.07	25072903
496	Phosphorylation	EKGDSSRY------- CCCCCCCC-------	25.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBY1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBY1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBY1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBY1A_HUMAN	RBMY1A1	physical	25416956
DAAM2_HUMAN	DAAM2	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
RBMX_HUMAN	RBMX	physical	25416956
ABC3C_HUMAN	APOBEC3C	physical	25416956
PCDBE_HUMAN	PCDHB14	physical	25416956
ZN317_HUMAN	ZNF317	physical	25416956
AEN_HUMAN	AEN	physical	25416956
PRR3_HUMAN	PRR3	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
CBX2_HUMAN	CBX2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.