DAAM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAAM2_HUMAN
• UniProt AC: Q86T65
• Protein Name: Disheveled-associated activator of morphogenesis 2
• Gene Name: DAAM2 {ECO:0000312|HGNC:HGNC:18143}
• Organism: Homo sapiens (Human).
• Sequence Length: 1068
• Protein Description: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly..
• Protein Sequence: MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
182	Acetylation	TSLIGCIKALMNNSQ HHHHHHHHHHHCCCC	39.27	20167786
355	Phosphorylation	MVHIDTKSASQMFEL EEEECCCCHHHHHHH	34.93	-
482	Phosphorylation	EKEEMMRTLNKMKDK HHHHHHHHHHHHHHH	19.45	28152594
487	Acetylation	MRTLNKMKDKLARES HHHHHHHHHHHHHHH	54.01	7429263
512	Phosphorylation	AELVAQLSELSTGPV HHHHHHHHHHCCCCC	25.14	20071362
589	Phosphorylation	PQDPYPSSDVPLRKK CCCCCCCCCCCCCCC	37.82	20071362
656	Phosphorylation	RHQKELGSTEDIYLA HHHHHHCCHHHHHHH	41.05	30266825
657	Phosphorylation	HQKELGSTEDIYLAS HHHHHCCHHHHHHHH	35.56	30266825
661	Phosphorylation	LGSTEDIYLASRKVK HCCHHHHHHHHHCCE	14.45	24702127
664	Phosphorylation	TEDIYLASRKVKELS HHHHHHHHHCCEEEE	30.00	24702127
671	Phosphorylation	SRKVKELSVIDGRRA HHCCEEEECCCCCHH	20.37	23403867
747	Phosphorylation	ARADRFLYEMSRIDH HHHHHHHHHHHHHHH	13.58	22817900
765	Acetylation	RLQALFFKKKFQERL HHHHHHHHHHHHHHH	47.95	19819117
766	Acetylation	LQALFFKKKFQERLA HHHHHHHHHHHHHHH	54.38	19819125
844	Phosphorylation	RNISLLHYLIMILEK HHHHHHHHHHHHHHH	9.63	22817900
1015	Phosphorylation	RKVLAAGSSLEEGGE HHHHHCCCCCCCCCC	27.33	29691806
1016	Phosphorylation	KVLAAGSSLEEGGEF HHHHCCCCCCCCCCH	38.59	26657352
1050	Phosphorylation	LKRSRKRSGSQALEV HHHHHCCCCCCHHHH	45.92	26657352
1052	Phosphorylation	RSRKRSGSQALEVTR HHHCCCCCCHHHHHH	17.33	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DAAM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAAM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAAM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
RBY1F_HUMAN	RBMY1F	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
SG2A1_HUMAN	SCGB2A1	physical	28514442
AVR2A_HUMAN	ACVR2A	physical	28514442
CD320_HUMAN	CD320	physical	28514442
PRAME_HUMAN	PRAME	physical	28514442
LGR4_HUMAN	LGR4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.