CD320_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD320_HUMAN
• UniProt AC: Q9NPF0
• Protein Name: CD320 antigen
• Gene Name: CD320
• Organism: Homo sapiens (Human).
• Sequence Length: 282
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor for transcobalamin saturated with cobalamin (TCbl). [PubMed: 18779389 Plays an important role in cobalamin uptake]
• Protein Sequence: MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	O-linked_Glycosylation	ASPLSTPTSAQAAGP HCCCCCCCCHHHCCC	36.46	OGP
43	O-linked_Glycosylation	SPLSTPTSAQAAGPS CCCCCCCCHHHCCCC	21.42	OGP
50	O-linked_Glycosylation	SAQAAGPSSGSCPPT CHHHCCCCCCCCCCC	46.55	OGP
63	O-linked_Glycosylation	PTKFQCRTSGLCVPL CCCEEECCCCCEEEE	34.47	OGP
63	Phosphorylation	PTKFQCRTSGLCVPL CCCEEECCCCCEEEE	34.47	27080861
64	Phosphorylation	TKFQCRTSGLCVPLT CCEEECCCCCEEEEE	15.49	27080861
71	Phosphorylation	SGLCVPLTWRCDRDL CCCEEEEEEEECCCC	12.56	27080861
81	Phosphorylation	CDRDLDCSDGSDEEE ECCCCCCCCCCCHHH	44.68	29759185
84	Phosphorylation	DLDCSDGSDEEECRI CCCCCCCCCHHHCCE	47.00	28985074
95	Phosphorylation	ECRIEPCTQKGQCPP HCCEECCCCCCCCCC	43.99	-
95	O-linked_Glycosylation	ECRIEPCTQKGQCPP HCCEECCCCCCCCCC	43.99	OGP
97	Ubiquitination	RIEPCTQKGQCPPPP CEECCCCCCCCCCCC	32.56	-
111	Phosphorylation	PGLPCPCTGVSDCSG CCCCCCCCCCCCCCC	26.26	25627689
111	O-linked_Glycosylation	PGLPCPCTGVSDCSG CCCCCCCCCCCCCCC	26.26	OGP
114	Phosphorylation	PCPCTGVSDCSGGTD CCCCCCCCCCCCCCC	33.95	25627689
117	Phosphorylation	CTGVSDCSGGTDKKL CCCCCCCCCCCCHHH	45.29	25627689
120	Phosphorylation	VSDCSGGTDKKLRNC CCCCCCCCCHHHHHH	48.44	25627689
122	Ubiquitination	DCSGGTDKKLRNCSR CCCCCCCHHHHHHHH	54.25	-
123	Ubiquitination	CSGGTDKKLRNCSRL CCCCCCHHHHHHHHH	56.33	-
126	N-linked_Glycosylation	GTDKKLRNCSRLACL CCCHHHHHHHHHHHH	38.25	UniProtKB CARBOHYD
140	O-linked_Glycosylation	LAGELRCTLSDDCIP HHHHHEEEECCCEEE	23.90	OGP
179	O-linked_Glycosylation	ILPEGDATTMGPPVT CCCCCCCCCCCCCEE	23.27	OGP
180	O-linked_Glycosylation	LPEGDATTMGPPVTL CCCCCCCCCCCCEEH	23.11	OGP
186	O-linked_Glycosylation	TTMGPPVTLESVTSL CCCCCCEEHHHHHHC	30.49	OGP
195	N-linked_Glycosylation	ESVTSLRNATTMGPP HHHHHCCCCCCCCCC	47.10	UniProtKB CARBOHYD
213	N-linked_Glycosylation	ESVPSVGNATSSSAG ECCCCCCCCCCCCCC	37.58	UniProtKB CARBOHYD
227	Ubiquitination	GDQSGSPTAYGVIAA CCCCCCCCHHHHHHH	33.92	23000965
236	Ubiquitination	YGVIAAAAVLSASLV HHHHHHHHHHHHHHH	9.69	21963094
269	Ubiquitination	LGLLVAMKESLLLSE HHHHHHHHHHHHHHH	34.12	23000965
275	Phosphorylation	MKESLLLSEQKTSLP HHHHHHHHHHCCCCC	37.64	21815630
278	Ubiquitination	SLLLSEQKTSLP--- HHHHHHHCCCCC---	35.71	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD320_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD320_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD320_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX2_HUMAN	PRDX2	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613646: Methylmalonic aciduria type TCblR (MMATC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.