RBY1F_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBY1F_HUMAN
• UniProt AC: Q15415
• Protein Name: RNA-binding motif protein, Y chromosome, family 1 member F/J
• Gene Name: RBMY1F
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Nucleus.
• Protein Description: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis..
• Protein Sequence: MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSSGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	AKDMNGTSLHGKAIK HHHCCCCCCCCCEEE	21.55	24719451
104	O-linked_Glycosylation	PASSRNRSPSGSLRS CCCCCCCCCCCCCCC	27.28	30379171
104	Phosphorylation	PASSRNRSPSGSLRS CCCCCCCCCCCCCCC	27.28	25072903
106	Phosphorylation	SSRNRSPSGSLRSAR CCCCCCCCCCCCCCC	42.11	25072903
108	Phosphorylation	RNRSPSGSLRSARGS CCCCCCCCCCCCCCC	25.58	25072903
111	Phosphorylation	SPSGSLRSARGSSGG CCCCCCCCCCCCCCC	27.84	25072903
115	Phosphorylation	SLRSARGSSGGTRGW CCCCCCCCCCCCCCC	21.91	-
116	Phosphorylation	LRSARGSSGGTRGWL CCCCCCCCCCCCCCC	44.03	-
125	Phosphorylation	GTRGWLPSHEGHLDD CCCCCCCCCCCCCCC	31.81	25072903
135	Phosphorylation	GHLDDGGYTPDLKMS CCCCCCCCCCCCCEE	22.19	25072903
136	Phosphorylation	HLDDGGYTPDLKMSY CCCCCCCCCCCCEEE	17.38	25072903
155	Phosphorylation	IPVKRGPSSRSGGPP EEECCCCCCCCCCCC	41.00	28348404
156	Phosphorylation	PVKRGPSSRSGGPPP EECCCCCCCCCCCCC	33.33	28348404
158	Phosphorylation	KRGPSSRSGGPPPKK CCCCCCCCCCCCCCC	50.48	28348404
174	Phosphorylation	APSAVARSNSWMGSQ CCCHHHHCCCCCCCC	26.02	25072903
176	Phosphorylation	SAVARSNSWMGSQGP CHHHHCCCCCCCCCC	21.49	25072903
180	Phosphorylation	RSNSWMGSQGPMSQR HCCCCCCCCCCCHHH	18.83	25072903
290	Phosphorylation	SRRDESYSRGYRNHR CCCCCHHCCCCCCCC	28.63	29759185
342	Phosphorylation	SSRETRDYAPPHRDY CCCCCCCCCCCCCCC	20.09	-
351	Phosphorylation	PPHRDYAYRDYGHSS CCCCCCCCCCCCCCC	9.59	-
363	Phosphorylation	HSSWDEHSSRGYSYH CCCCCCCCCCCCCCC	21.49	-
364	Phosphorylation	SSWDEHSSRGYSYHD CCCCCCCCCCCCCCC	31.47	-
368	Phosphorylation	EHSSRGYSYHDGYGE CCCCCCCCCCCCCHH	20.86	22210691
373	Phosphorylation	GYSYHDGYGEALGRD CCCCCCCCHHHHCCC	20.18	22210691
389	Phosphorylation	SEHLSGSSYRDALQR CHHCCCCHHHHHHHH	27.93	22210691
428	Phosphorylation	YSNTRDRYGRSWESY ECCCCCCCCCCCHHH	22.60	-
435	Phosphorylation	YGRSWESYSSCGDFH CCCCCHHHCCCCCCC	7.96	-
437	Phosphorylation	RSWESYSSCGDFHYC CCCHHHCCCCCCCCC	17.56	-
443	Phosphorylation	SSCGDFHYCDREHVC CCCCCCCCCCHHHHH	8.95	-
459	Phosphorylation	KDQRNPPSLGRVLPD CCCCCCCCCCCCCCC	44.72	27499020
471	Phosphorylation	LPDPREAYGSSSYVA CCCHHHHHCCCCEEE	16.88	-
473	Phosphorylation	DPREAYGSSSYVASI CHHHHHCCCCEEEEE	11.93	25072903
475	Phosphorylation	REAYGSSSYVASIVD HHHHCCCCEEEEEEC	25.89	25072903
476	Phosphorylation	EAYGSSSYVASIVDG HHHCCCCEEEEEECC	11.28	-
479	Phosphorylation	GSSSYVASIVDGGES CCCCEEEEEECCCCC	17.07	25072903
496	Phosphorylation	EKGDSSRY------- CCCCCCCC-------	25.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBY1F_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBY1F_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBY1F_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBY1F_HUMAN	RBMY1F	physical	25416956
HNRPK_HUMAN	HNRNPK	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.