| UniProt ID | LGR4_HUMAN | |
|---|---|---|
| UniProt AC | Q9BXB1 | |
| Protein Name | Leucine-rich repeat-containing G-protein coupled receptor 4 | |
| Gene Name | LGR4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 951 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).. | |
| Protein Sequence | MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 68 | N-linked_Glycosylation | ALDISMNNITQLPED HHHCCCCCCCCCCHH | 30.00 | 23756652 | |
| 108 | Acetylation | LSGLKELKVLTLQNN HHCCCCEEEEEEECC | 35.97 | 19825833 | |
| 142 | Phosphorylation | RLDANHITSVPEDSF CCCCCCCCCCCCCCH | 19.00 | 29759185 | |
| 143 | Phosphorylation | LDANHITSVPEDSFE CCCCCCCCCCCCCHH | 34.76 | 29759185 | |
| 199 | N-linked_Glycosylation | IPDFAFTNLSSLVVL CCCHHHCCHHHHHEE | 31.32 | 23756652 | |
| 249 | Phosphorylation | QAIKALPSLKELGFH HHHHHCCCHHHHCCC | 53.58 | 24719451 | |
| 294 | N-linked_Glycosylation | VGNSAFHNLSDLHSL HCCHHCCCHHHHHHH | 34.48 | UniProtKB CARBOHYD | |
| 314 | N-linked_Glycosylation | SMVQQFPNLTGTVHL HHHHHCCCCCCEEEE | 52.07 | UniProtKB CARBOHYD | |
| 332 | Phosphorylation | TLTGTKISSIPNNLC EEECCCHHHCCCCHH | 24.62 | 18452278 | |
| 333 | Phosphorylation | LTGTKISSIPNNLCQ EECCCHHHCCCCHHH | 45.60 | 18452278 | |
| 371 | Phosphorylation | CHALEEISLQRNQIY CCCHHHHHCCCCCEE | 23.02 | 24719451 | |
| 505 | N-linked_Glycosylation | KGTADAANVTSTLEN HCCCCHHCCCHHCCC | 39.04 | UniProtKB CARBOHYD | |
| 616 | Phosphorylation | GIWWETGSGCKVAGF EEEEECCCCCEEEEE | 48.73 | - | |
| 848 | Phosphorylation | FYYDCGMYSHLQGNL EEECCCCHHHHCCCE | 4.35 | - | |
| 873 | Ubiquitination | LTKPVSCKHLIKSHS CCCCCCCHHHHHHCC | 33.66 | - | |
| 878 | Phosphorylation | SCKHLIKSHSCPALA CCHHHHHHCCCCEEE | 17.40 | 24275569 | |
| 880 | Phosphorylation | KHLIKSHSCPALAVA HHHHHHCCCCEEEEE | 28.96 | 22468782 | |
| 908 | Phosphorylation | TQSAHSDYADEEDSF CCCCCCCCCCCCCCC | 20.97 | 22817900 | |
| 917 | Phosphorylation | DEEDSFVSDSSDQVQ CCCCCCCCCCHHHHH | 29.75 | 24275569 | |
| 919 | Phosphorylation | EDSFVSDSSDQVQAC CCCCCCCCHHHHHHH | 28.45 | 24275569 | |
| 920 | Phosphorylation | DSFVSDSSDQVQACG CCCCCCCHHHHHHHH | 36.73 | 11401528 | |
| 932 | Phosphorylation | ACGRACFYQSRGFPL HHHHHHHHHHCCCCC | 12.88 | 25884760 | |
| 942 | Phosphorylation | RGFPLVRYAYNLPRV CCCCCCEEECCCCCC | 13.12 | 25884760 | |
| 944 | Phosphorylation | FPLVRYAYNLPRVKD CCCCEEECCCCCCCC | 14.32 | 25884760 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LGR4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LGR4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 166710 | Osteoporosis (OSTEOP) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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