dbPTM

IF4G3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IF4G3_HUMAN
UniProt AC	O43432
Protein Name	Eukaryotic translation initiation factor 4 gamma 3
Gene Name	EIF4G3
Organism	Homo sapiens (Human).
Sequence Length	1585
Subcellular Localization
Protein Description	Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1..
Protein Sequence	MNSQPQTRSPFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITVQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPLLNVGSRRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPSQKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLTSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREADLSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEESEDN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	NSQPQTRSPFFQRPQ CCCCCCCCCCCCCCC	29.46	24850871
9 (in isoform 2)	Phosphorylation	-	29.46	-
119	Phosphorylation	FYPSQPVYQSAPIIV CCCCCCCCCCCCEEE	11.93	-
152	Acetylation	RDPNQGGKDITEEIM CCCCCCCCCCHHHHH	53.43	23749302
155	Phosphorylation	NQGGKDITEEIMSGG CCCCCCCHHHHHCCC	37.39	27732954
160	Phosphorylation	DITEEIMSGGGSRNP CCHHHHHCCCCCCCC	39.69	29255136
164	Phosphorylation	EIMSGGGSRNPTPPI HHHCCCCCCCCCCCC	31.96	29255136
168	Phosphorylation	GGGSRNPTPPIGRPT CCCCCCCCCCCCCCC	45.29	26657352
175	Phosphorylation	TPPIGRPTSTPTPPQ CCCCCCCCCCCCCCC	43.82	27251275
175 (in isoform 3)	Phosphorylation	-	43.82	28348404
176	Phosphorylation	PPIGRPTSTPTPPQQ CCCCCCCCCCCCCCC	34.76	27251275
177	Phosphorylation	PIGRPTSTPTPPQQL CCCCCCCCCCCCCCC	33.39	27251275
179	Phosphorylation	GRPTSTPTPPQQLPS CCCCCCCCCCCCCCC	47.92	27251275
182 (in isoform 3)	Phosphorylation	-	59.66	28348404
183 (in isoform 3)	Phosphorylation	-	62.20	28348404
184 (in isoform 3)	Phosphorylation	-	3.57	28348404
186 (in isoform 3)	Phosphorylation	-	53.02	28348404
202 (in isoform 3)	Phosphorylation	-	6.55	28348404
204 (in isoform 3)	Phosphorylation	-	4.21	28348404
207 (in isoform 3)	Phosphorylation	-	27.86	28348404
208	Phosphorylation	SAHLAASTPVTAASD HHHHHHCCCCCCCCC	19.63	22468782
211	O-linked_Glycosylation	LAASTPVTAASDQKQ HHHCCCCCCCCCCCC	20.08	23301498
213 (in isoform 3)	Phosphorylation	-	12.32	28348404
214 (in isoform 3)	Phosphorylation	-	37.80	28348404
229	Methylation	PKPDPVLKSPSPVLR CCCCCCCCCCCHHHH	61.63	-
229	Phosphorylation	PKPDPVLKSPSPVLR CCCCCCCCCCCHHHH	61.63	24719451
230	Phosphorylation	KPDPVLKSPSPVLRL CCCCCCCCCCHHHHH	26.84	22167270
231	Phosphorylation	PDPVLKSPSPVLRLV CCCCCCCCCHHHHHH	40.85	24719451
232	O-linked_Glycosylation	DPVLKSPSPVLRLVL CCCCCCCCHHHHHHH	34.43	23301498
232	Phosphorylation	DPVLKSPSPVLRLVL CCCCCCCCHHHHHHH	34.43	22167270
239	Phosphorylation	SPVLRLVLSGEKKEQ CHHHHHHHCCCCCCC	6.87	24719451
240	Phosphorylation	PVLRLVLSGEKKEQE HHHHHHHCCCCCCCC	37.11	28355574
243	Acetylation	RLVLSGEKKEQEGQT HHHHCCCCCCCCCCC	66.20	25953088
267	Phosphorylation	AELPLPPSPTTVSSV EECCCCCCCCCHHHH	32.70	26471730
269	Phosphorylation	LPLPPSPTTVSSVAR CCCCCCCCCHHHHHH	44.14	26471730
270	Phosphorylation	PLPPSPTTVSSVARS CCCCCCCCHHHHHHC	23.06	24275569
272	Phosphorylation	PPSPTTVSSVARSTI CCCCCCHHHHHHCCC	19.59	26471730
273	Phosphorylation	PSPTTVSSVARSTIA CCCCCHHHHHHCCCC	18.56	26471730
277	O-linked_Glycosylation	TVSSVARSTIAAPTS CHHHHHHCCCCCCCC	17.90	23301498
278	O-linked_Glycosylation	VSSVARSTIAAPTSS HHHHHHCCCCCCCCH	14.74	23301498
283	O-linked_Glycosylation	RSTIAAPTSSALSSQ HCCCCCCCCHHHHCC	30.50	23301498
284	O-linked_Glycosylation	STIAAPTSSALSSQP CCCCCCCCHHHHCCC	16.74	23301498
285	O-linked_Glycosylation	TIAAPTSSALSSQPI CCCCCCCHHHHCCCC	35.39	23301498
289	O-linked_Glycosylation	PTSSALSSQPIFTTA CCCHHHHCCCCEEEE	40.60	23301498
294	O-linked_Glycosylation	LSSQPIFTTAIDDRC HHCCCCEEEEECCCC	18.94	23301498
304	Phosphorylation	IDDRCELSSPREDTI ECCCCCCCCCCCCCC	18.92	29255136
305	Phosphorylation	DDRCELSSPREDTIP CCCCCCCCCCCCCCC	40.37	26657352
310	Phosphorylation	LSSPREDTIPIPSLT CCCCCCCCCCCCCCC	24.73	27251275
315	Phosphorylation	EDTIPIPSLTSCTET CCCCCCCCCCCCCCC	45.03	27251275
317	Phosphorylation	TIPIPSLTSCTETSD CCCCCCCCCCCCCCC	26.54	27251275
318	Phosphorylation	IPIPSLTSCTETSDP CCCCCCCCCCCCCCC	25.08	27251275
320	Phosphorylation	IPSLTSCTETSDPLP CCCCCCCCCCCCCCC	41.90	27251275
322	Phosphorylation	SLTSCTETSDPLPTN CCCCCCCCCCCCCCC	21.92	27251275
351	Phosphorylation	PNDIPLVSSTNLINE CCCCCCCCCCHHHHH	38.84	28348404
352	Phosphorylation	NDIPLVSSTNLINEI CCCCCCCCCHHHHHH	17.52	28348404
353	Phosphorylation	DIPLVSSTNLINEIN CCCCCCCCHHHHHHC	26.91	28348404
367	Phosphorylation	NGVSEKLSATESIVE CCCCHHCCCCHHHHH	44.18	25693802
369	Phosphorylation	VSEKLSATESIVEIV CCHHCCCCHHHHHHH	27.21	25693802
370	Phosphorylation	SEKLSATESIVEIVK CHHCCCCHHHHHHHH	37.88	27251275
371	Phosphorylation	EKLSATESIVEIVKQ HHCCCCHHHHHHHHH	27.81	25693802
413	Phosphorylation	ITPSTVPSFPPTPPT CCCCCCCCCCCCCCC	46.15	28348404
417	Phosphorylation	TVPSFPPTPPTPPAS CCCCCCCCCCCCCCC	41.98	28348404
420	Phosphorylation	SFPPTPPTPPASPPH CCCCCCCCCCCCCCC	43.01	28348404
424	Phosphorylation	TPPTPPASPPHTPVI CCCCCCCCCCCCCEE	44.75	28348404
428	Phosphorylation	PPASPPHTPVIVPAA CCCCCCCCCEEECCC	25.65	28348404
437	Phosphorylation	VIVPAAATTVSSPSA EEECCCCCCCCCCCH	24.01	28348404
438	Phosphorylation	IVPAAATTVSSPSAA EECCCCCCCCCCCHH	17.42	28348404
441	Phosphorylation	AAATTVSSPSAAITV CCCCCCCCCCHHHHH	20.66	-
463	Phosphorylation	ESIRTCLSEDAKEIQ HHHHHHCCHHHHHHH	35.26	28348404
481	Phosphorylation	EVEADGQTEEILDSQ EEECCCCCHHHHHCC	40.91	26699800
487	Phosphorylation	QTEEILDSQNLNSRR CCHHHHHCCCCCCCC	19.95	25159151
492	Phosphorylation	LDSQNLNSRRSPVPA HHCCCCCCCCCCCCC	32.03	25159151
494	Phosphorylation	SQNLNSRRSPVPAQI CCCCCCCCCCCCCEE	45.17	24719451
495	Phosphorylation	QNLNSRRSPVPAQIA CCCCCCCCCCCCEEE	29.19	19664994
503	Phosphorylation	PVPAQIAITVPKTWK CCCCEEEEECCCCCC	4.22	27251275
504	Phosphorylation	VPAQIAITVPKTWKK CCCEEEEECCCCCCC	23.02	23927012
506 (in isoform 2)	Phosphorylation	-	21.51	25850435
516	Phosphorylation	WKKPKDRTRTTEEML CCCCCCCCCCHHHHH	42.36	28555341
518	Phosphorylation	KPKDRTRTTEEMLEA CCCCCCCCHHHHHHH	37.64	28450419
519	Phosphorylation	PKDRTRTTEEMLEAE CCCCCCCHHHHHHHH	27.02	28450419
536	Phosphorylation	LKAEEELSIDKVLES HHHHHHCCHHHHHHC	31.83	21815630
543	Phosphorylation	SIDKVLESEQDKMSQ CHHHHHHCHHHHHHC	36.08	23312004
549	Phosphorylation	ESEQDKMSQGFHPER HCHHHHHHCCCCCCC	32.65	23312004
583	Phosphorylation	PVRNGAESVSEGEGI CCCCCCCCCCCCCCC	30.34	26471730
585	Phosphorylation	RNGAESVSEGEGIDA CCCCCCCCCCCCCCC	49.52	26471730
594	Phosphorylation	GEGIDANSGSTDSSG CCCCCCCCCCCCCCC	35.52	26471730
596	Phosphorylation	GIDANSGSTDSSGDG CCCCCCCCCCCCCCC	28.94	26471730
597	Phosphorylation	IDANSGSTDSSGDGV CCCCCCCCCCCCCCC	43.35	26471730
599	Phosphorylation	ANSGSTDSSGDGVTF CCCCCCCCCCCCCEE	35.99	26471730
600	Phosphorylation	NSGSTDSSGDGVTFP CCCCCCCCCCCCEEC	43.65	26471730
605	Phosphorylation	DSSGDGVTFPFKPES CCCCCCCEECCCCHH	30.99	26471730
612	Phosphorylation	TFPFKPESWKPTDTE EECCCCHHCCCCCCC	49.26	26471730
649	Phosphorylation	PEGLPPISDVVLDKI CCCCCCCHHHHHHCC	30.08	21815630
669	Methylation	PMRTLDPRILPRGPD CCCCCCCCCCCCCCC	42.62	-
673	Methylation	LDPRILPRGPDFTPA CCCCCCCCCCCCCHH	66.87	-
692	Methylation	GRQTPGGRGVPLLNV CCCCCCCCCCCCCCC	49.18	-
717	Phosphorylation	REPRKIITVSVKEDV CCCCEEEEEEECCCC	15.36	30177828
719	Phosphorylation	PRKIITVSVKEDVHL CCEEEEEEECCCCHH	20.87	30177828
736	O-linked_Glycosylation	AENAWKPSQKRDSQA HHHCCCCCCCCCCCC	44.61	23301498
737	Phosphorylation	ENAWKPSQKRDSQAD HHCCCCCCCCCCCCC	54.02	27251275
741	Phosphorylation	KPSQKRDSQADDPEN CCCCCCCCCCCCHHH	31.16	-
750	Ubiquitination	ADDPENIKTQELFRK CCCHHHHHHHHHHHH	56.59	-
755	Phosphorylation	NIKTQELFRKVRSIL HHHHHHHHHHHHHHH	7.56	27251275
760	Phosphorylation	ELFRKVRSILNKLTP HHHHHHHHHHHHHCH	34.12	24719451
764	Acetylation	KVRSILNKLTPQMFN HHHHHHHHHCHHHHH	50.74	26051181
778	Phosphorylation	NQLMKQVSGLTVDTE HHHHHHHHCCCCCHH	26.12	26356563
781	Phosphorylation	MKQVSGLTVDTEERL HHHHHCCCCCHHHHH	21.62	26356563
784	Phosphorylation	VSGLTVDTEERLKGV HHCCCCCHHHHHHHH	35.10	26356563
789	Ubiquitination	VDTEERLKGVIDLVF CCHHHHHHHHHHHHH	58.30	21890473
804	Phosphorylation	EKAIDEPSFSVAYAN HHHCCCCCHHHHHHH	28.27	-
857	Ubiquitination	ADDDVFEKKQKELEA CCHHHHHHHHHHHHH	49.38	-
866	Phosphorylation	QKELEAASAPEERTR HHHHHHCCCCHHHHH	51.94	-
889	Phosphorylation	KDKARRRSIGNIKFI HHHHHHHHHCCCHHH	32.79	21406692
894	Acetylation	RRSIGNIKFIGELFK HHHHCCCHHHHHHHH	34.62	26051181
894	Ubiquitination	RRSIGNIKFIGELFK HHHHCCCHHHHHHHH	34.62	21906983
894 (in isoform 1)	Ubiquitination	-	34.62	21890473
901	Acetylation	KFIGELFKLKMLTEA HHHHHHHHHHHHHHH	60.88	26051181
901	Ubiquitination	KFIGELFKLKMLTEA HHHHHHHHHHHHHHH	60.88	-
903	Acetylation	IGELFKLKMLTEAIM HHHHHHHHHHHHHHH	32.24	25953088
903	Malonylation	IGELFKLKMLTEAIM HHHHHHHHHHHHHHH	32.24	26320211
916	Acetylation	IMHDCVVKLLKNHDE HHHHHHHHHHHCCCH	27.92	26051181
919	Acetylation	DCVVKLLKNHDEESL HHHHHHHHCCCHHHH	63.77	26051181
919	Malonylation	DCVVKLLKNHDEESL HHHHHHHHCCCHHHH	63.77	26320211
919	Ubiquitination	DCVVKLLKNHDEESL HHHHHHHHCCCHHHH	63.77	-
938	Acetylation	RLLTTIGKDLDFEKA HHHHHHCCCCCHHHH	51.79	26051181
938	Malonylation	RLLTTIGKDLDFEKA HHHHHHCCCCCHHHH	51.79	26320211
938	Ubiquitination	RLLTTIGKDLDFEKA HHHHHHCCCCCHHHH	51.79	-
944	Acetylation	GKDLDFEKAKPRMDQ CCCCCHHHHHHHHHH	62.80	23749302
944	Malonylation	GKDLDFEKAKPRMDQ CCCCCHHHHHHHHHH	62.80	26320211
944	Ubiquitination	GKDLDFEKAKPRMDQ CCCCCHHHHHHHHHH	62.80	-
948	Methylation	DFEKAKPRMDQYFNQ CHHHHHHHHHHHHHH	40.37	-
972	Sulfoxidation	TSSRIRFMLQDVIDL CCHHHHHHHHHHHHH	2.06	21406390
1013	Ubiquitination	EEQEEQRKVQQLMTK HHHHHHHHHHHHHHH	44.05	-
1050	O-linked_Glycosylation	NSRVLDPSKFLKITK CCCCCCHHHCCCCCC	35.39	23301498
1051	Acetylation	SRVLDPSKFLKITKP CCCCCHHHCCCCCCC	61.17	25953088
1069	Ubiquitination	EKIQLVPKAQLGSWG HHEEECCHHHHCCCC	41.09	21890473
1069	Ubiquitination	EKIQLVPKAQLGSWG HHEEECCHHHHCCCC	41.09	21890473
1069 (in isoform 1)	Ubiquitination	-	41.09	21890473
1074	Phosphorylation	VPKAQLGSWGKGSSG CCHHHHCCCCCCCCC	41.05	27251275
1077	Methylation	AQLGSWGKGSSGGAK HHHCCCCCCCCCCCC	49.73	-
1079	Phosphorylation	LGSWGKGSSGGAKAS HCCCCCCCCCCCCCC	29.33	28348404
1080	Phosphorylation	GSWGKGSSGGAKASE CCCCCCCCCCCCCCH	50.33	28348404
1093	Phosphorylation	SETDALRSSASSLNR CHHHHHHHHHHHHHC	30.98	28348404
1094	Phosphorylation	ETDALRSSASSLNRF HHHHHHHHHHHHHCH	26.24	28348404
1102	Phosphorylation	ASSLNRFSALQPPAP HHHHHCHHCCCCCCC	25.49	23312004
1110	Phosphorylation	ALQPPAPSGSTPSTP CCCCCCCCCCCCCCC	47.70	28450419
1112	Phosphorylation	QPPAPSGSTPSTPVE CCCCCCCCCCCCCCC	41.29	28450419
1113	Phosphorylation	PPAPSGSTPSTPVEF CCCCCCCCCCCCCCC	25.45	28450419
1115	Phosphorylation	APSGSTPSTPVEFDS CCCCCCCCCCCCCCC	45.49	28450419
1116	Phosphorylation	PSGSTPSTPVEFDSR CCCCCCCCCCCCCCC	32.34	25159151
1122	Phosphorylation	STPVEFDSRRTLTSR CCCCCCCCCCCCCCC	29.05	28450419
1127	Phosphorylation	FDSRRTLTSRGSMGR CCCCCCCCCCCCCCC	18.76	26434776
1128	Phosphorylation	DSRRTLTSRGSMGRE CCCCCCCCCCCCCCC	37.44	23403867
1130	Phosphorylation	RRTLTSRGSMGREKN CCCCCCCCCCCCCCC	23.04	27251275
1131	Phosphorylation	RTLTSRGSMGREKND CCCCCCCCCCCCCCC	19.56	23403867
1143	Phosphorylation	KNDKPLPSATARPNT CCCCCCCCCCCCCCC	46.03	29514088
1145	Phosphorylation	DKPLPSATARPNTFM CCCCCCCCCCCCCCC	27.77	29514088
1146	Phosphorylation	KPLPSATARPNTFMR CCCCCCCCCCCCCCC	25.34	24719451
1150	Phosphorylation	SATARPNTFMRGGSS CCCCCCCCCCCCCCH	22.84	26074081
1151	Phosphorylation	ATARPNTFMRGGSSK CCCCCCCCCCCCCHH	3.90	27251275
1156	Phosphorylation	NTFMRGGSSKDLLDN CCCCCCCCHHHHHCC	36.72	22167270
1157	Phosphorylation	TFMRGGSSKDLLDNQ CCCCCCCHHHHHCCC	33.20	30266825
1165	Phosphorylation	KDLLDNQSQEEQRRE HHHHCCCCHHHHHHH	45.90	23927012
1167	Phosphorylation	LLDNQSQEEQRREML HHCCCCHHHHHHHHH	62.43	24719451
1181	Phosphorylation	LETVKQLTGGVDVER HHHHHHHHCCCCCCC	29.42	23612710
1190	Phosphorylation	GVDVERNSTEAERNK CCCCCCCCHHHHHHH	33.57	29978859
1191	Phosphorylation	VDVERNSTEAERNKT CCCCCCCHHHHHHHH	42.64	29978859
1192	Phosphorylation	DVERNSTEAERNKTR CCCCCCHHHHHHHHH	48.64	24719451
1198	Phosphorylation	TEAERNKTRESAKPE HHHHHHHHHHHHCHH	43.12	28555341
1201	Phosphorylation	ERNKTRESAKPEISA HHHHHHHHHCHHHHH	38.00	28555341
1207	Phosphorylation	ESAKPEISAMSAHDK HHHCHHHHHHHHHHH	19.09	25332170
1218	Phosphorylation	AHDKAALSEEELERK HHHHHHCCHHHHHHH	37.93	27067055
1226	Phosphorylation	EEELERKSKSIIDEF HHHHHHHHHHHHHHH	37.54	27251275
1240	Acetylation	FLHINDFKEAMQCVE HHCCCHHHHHHHHHH	47.64	30588455
1265	Phosphorylation	FVRVGVESTLERSQI EHHCCCCHHHCHHHC	35.57	26270265
1266	Phosphorylation	VRVGVESTLERSQIT HHCCCCHHHCHHHCC	21.09	26270265
1270	Phosphorylation	VESTLERSQITRDHM CCHHHCHHHCCHHHH	19.29	26270265
1273	Phosphorylation	TLERSQITRDHMGQL HHCHHHCCHHHHHHH	23.54	26270265
1292	Ubiquitination	VQSEKLSKQDFFKGF HHCHHHCHHHHHHHH	65.41	-
1343	Phosphorylation	RELTIEFSKPLLPVG EEEEEEECCCCCCCC	22.15	19413330
1407	Phosphorylation	QKLDFIESDSPCSSE HHCHHHHCCCCCCHH	38.27	30266825
1409	Phosphorylation	LDFIESDSPCSSEAL CHHHHCCCCCCHHHH	36.77	29255136
1412	Phosphorylation	IESDSPCSSEALSKK HHCCCCCCHHHHCCC	34.30	30266825
1413	Phosphorylation	ESDSPCSSEALSKKE HCCCCCCHHHHCCCC	33.34	30266825
1417	Phosphorylation	PCSSEALSKKELSAE CCCHHHHCCCCCCHH	49.05	30266825
1419	Ubiquitination	SSEALSKKELSAEEL CHHHHCCCCCCHHHH	61.59	-
1422	Phosphorylation	ALSKKELSAEELYKR HHCCCCCCHHHHHHH	34.42	29083192
1427	Phosphorylation	ELSAEELYKRLEKLI CCCHHHHHHHHHHHH	9.42	29083192
1428	Ubiquitination	LSAEELYKRLEKLII CCHHHHHHHHHHHHH	64.23	-
1432	Ubiquitination	ELYKRLEKLIIEDKA HHHHHHHHHHHCCCC	49.96	-
1443	Phosphorylation	EDKANDEQIFDWVEA CCCCCHHHHHHHHHH	44.50	27251275
1445	Phosphorylation	KANDEQIFDWVEANL CCCHHHHHHHHHHCH	6.38	24719451
1479	Phosphorylation	KAAIIADSSTFRVDT HHHHHCCCCCEEECH	23.43	21815630
1480	Phosphorylation	AAIIADSSTFRVDTA HHHHCCCCCEEECHH	31.92	25627689
1481	Phosphorylation	AIIADSSTFRVDTAV HHHCCCCCEEECHHH	21.29	25627689
1506	Ubiquitination	YLDSDTEKELQALYA HCCCCCHHHHHHHHH	66.86	-
1566	Acetylation	NGKGVALKSVTAFFT CCCCEEHHHHHHHHH	32.89	26051181
1582	Phosphorylation	LREAEEESEDN---- HHHHHHHHCCC----	54.23	27422710

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1156	S	Phosphorylation	Kinase	CAMK1A	Q14012	PSP
1156	S	Phosphorylation	Kinase	PNCK	Q6P2M8	GPS
1156	S	Phosphorylation	Kinase	CAMK1G	Q96NX5	PSP
1156	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IF4G3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IF4G3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	9857202
PABP1_HUMAN	PABPC1	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
SF3A2_HUMAN	SF3A2	physical	26344197
IF4E_HUMAN	EIF4E	physical	9418880
IF4A1_HUMAN	EIF4A1	physical	9418880
EIF3B_HUMAN	EIF3B	physical	9418880

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IF4G3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-944, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232 AND SER-1409, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232 AND SER-495, ANDMASS SPECTROMETRY.	18088087 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction."; Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.; Mol. Cell. Proteomics 6:1952-1967(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASSSPECTROMETRY.	17693683 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230; SER-232 ANDSER-495, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Phosphorylation screening identifies translational initiation factor4GII as an intracellular target of Ca(2+)/calmodulin-dependent proteinkinase I."; Qin H., Raught B., Sonenberg N., Goldstein E.G., Edelman A.M.; J. Biol. Chem. 278:48570-48579(2003). Cited for: PHOSPHORYLATION AT SER-1156 BY CAMK1.	14507913 [Abstract]