POTEJ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POTEJ_HUMAN
• UniProt AC: P0CG39
• Protein Name: POTE ankyrin domain family member J
• Gene Name: POTEJ
• Organism: Homo sapiens (Human).
• Sequence Length: 1038
• Protein Sequence: MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKERDFLHENSMLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGCPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMVASSSSLEKSYELPDGQVITISNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVAEVDSMPAASSV -CCCCCCCCCCCCCC	31.66	23663014
12	Phosphorylation	VDSMPAASSVKKPFV CCCCCCCCCCCCCEE	37.46	23663014
13	Phosphorylation	DSMPAASSVKKPFVL CCCCCCCCCCCCEEH	32.98	23663014
22	Phosphorylation	KKPFVLRSKMGKWCR CCCEEHHCCCCCCHH	23.88	21406692
38	Phosphorylation	CFPCCRGSGKSNVGT HCCCCCCCCCCCCCC	24.56	22210691
46	Phosphorylation	GKSNVGTSGDQDDST CCCCCCCCCCCCHHH	34.15	-
53	Phosphorylation	SGDQDDSTMKTLRSK CCCCCHHHHHHHHHH	29.67	22210691
56	Phosphorylation	QDDSTMKTLRSKMGK CCHHHHHHHHHHCCC	19.31	-
77	Ubiquitination	PCCRGSGKSNVGAWG CCCCCCCCCCCCCCC	40.32	32142685
138	Phosphorylation	KQDKQKRTALHLASA HHHHHHHHHHHHHHC	40.38	-
171	Phosphorylation	VLDNKKRTALTKAVQ ECCCHHHHHHHHHHH	34.59	-
230	Phosphorylation	LYGADIESKNKHGLT HHCCCHHHCCCCCCC	41.69	26074081
231	Ubiquitination	YGADIESKNKHGLTP HCCCHHHCCCCCCCC	58.17	23000965
233	Ubiquitination	ADIESKNKHGLTPLL CCHHHCCCCCCCCCE	42.67	23000965
237	Phosphorylation	SKNKHGLTPLLLGVH HCCCCCCCCCEEEHH	19.24	-
241	Ubiquitination	HGLTPLLLGVHEQKQ CCCCCCEEEHHHHHH	9.92	23000965
243	Ubiquitination	LTPLLLGVHEQKQQV CCCCEEEHHHHHHHH	4.53	23000965
258	Ubiquitination	VKFLIKKKANLNALD HHHHHHHCCCCCHHH	37.19	-
266	Ubiquitination	ANLNALDRYGRTALI CCCCHHHHHCCHHHH	36.33	22817900
267	Ubiquitination	NLNALDRYGRTALIL CCCHHHHHCCHHHHH	15.61	22817900
268	Ubiquitination	LNALDRYGRTALILA CCHHHHHCCHHHHHH	22.74	22817900
284	Ubiquitination	CCGSASIVSLLLEQN HCCCHHHHHHHHHCC	2.82	22817900
285	Ubiquitination	CGSASIVSLLLEQNI CCCHHHHHHHHHCCC	16.19	22817900
286	Ubiquitination	GSASIVSLLLEQNID CCHHHHHHHHHCCCC	4.36	22817900
300	Ubiquitination	DVSSQDLSGQTAREY CCCHHCCCCCHHHHH	36.82	22817900
318	Ubiquitination	SHHHVICQLLSDYKE CCHHHHHHHHCCHHH	34.02	22817900
333	Phosphorylation	KQMLKISSENSNPEQ HHCCCCCCCCCCHHH	44.25	-
346	Phosphorylation	EQDLKLTSEEESQRF HHHCCCCCHHHHHHH	54.14	-
366	Ubiquitination	SQPEKMSQEPEINKD CCCCHHCCCCCCCCC	67.76	22817900
384	Ubiquitination	EVEEEMKKHESNNVG HHHHHHHHHHCCCCC	51.82	22817900
395	Ubiquitination	NNVGLLENLSNGVTA CCCCHHHHHCCCCCC	49.06	22817900
400	Ubiquitination	LENLSNGVTAGNGDD HHHHCCCCCCCCCCC	3.76	22817900
413	Ubiquitination	DDGLIPQRKSRTPEN CCCCCCCCCCCCCCC	33.30	22817900
418	Ubiquitination	PQRKSRTPENQQFPD CCCCCCCCCCCCCCC	37.11	22817900
431	Phosphorylation	PDNESEEYHRICELV CCCCCHHHHHHHHHH	7.73	-
439	Phosphorylation	HRICELVSDYKEKQM HHHHHHHHHHHHHHC	48.09	-
441	Phosphorylation	ICELVSDYKEKQMPK HHHHHHHHHHHHCCC	17.34	-
451	Phosphorylation	KQMPKYSSENSNPEQ HHCCCCCCCCCCHHH	37.39	-
464	Phosphorylation	EQDLKLTSEEESQRL HHHHCCCCHHHHHHH	54.14	-
473	Ubiquitination	EESQRLKGSENGQPE HHHHHHCCCCCCCCC	44.79	22817900
491	Ubiquitination	QEPEINKDGDRELEN CCCCCCCCCCHHHHH	60.79	22817900
495	Ubiquitination	INKDGDRELENFMAI CCCCCCHHHHHHHHH	66.24	22817900
497	Ubiquitination	KDGDRELENFMAIEE CCCCHHHHHHHHHHH	43.60	22817900
510	Phosphorylation	EEMKKHGSTHVGFPE HHHHHHCCCCCCCCC	18.30	20860994
511	Phosphorylation	EMKKHGSTHVGFPEN HHHHHCCCCCCCCCC	25.77	20860994
513	Ubiquitination	KKHGSTHVGFPENLT HHHCCCCCCCCCCCC	9.53	22817900
515	Ubiquitination	HGSTHVGFPENLTNG HCCCCCCCCCCCCCC	7.16	22817900
520	Ubiquitination	VGFPENLTNGATAGN CCCCCCCCCCCCCCC	43.09	22817900
524	Phosphorylation	ENLTNGATAGNGDDG CCCCCCCCCCCCCCC	36.17	20860994
538	Ubiquitination	GLIPPRKSRTPESQQ CCCCCCCCCCCCHHC	42.54	22817900
612	Phosphorylation	RDFLHENSMLREEIA HHHHHHCHHHHHHHH	19.06	30576142
639	Phosphorylation	SQLRKKKYLEDIESV HHHHHHHHHHHHHHH	24.97	28258704
645	Phosphorylation	KYLEDIESVKKKNDN HHHHHHHHHHHHCCH	39.30	20068231
647	Ubiquitination	LEDIESVKKKNDNLL HHHHHHHHHHCCHHH	68.27	22817900
648	Ubiquitination	EDIESVKKKNDNLLK HHHHHHHHHCCHHHH	55.44	22817900
649	Ubiquitination	DIESVKKKNDNLLKA HHHHHHHHCCHHHHH	64.91	22817900
657	Ubiquitination	NDNLLKALQLNELTM CCHHHHHHHCCCCCC	5.94	22817900
658	Ubiquitination	DNLLKALQLNELTMD CHHHHHHHCCCCCCC	47.29	22817900
659	Ubiquitination	NLLKALQLNELTMDD HHHHHHHCCCCCCCC	5.82	22817900
668	Phosphorylation	ELTMDDDTAVLVIDN CCCCCCCCEEEEEEC	26.17	24850871
677	Phosphorylation	VLVIDNGSGMCKAGF EEEEECCCCCCCCCC	29.61	-
681	Ubiquitination	DNGSGMCKAGFAGDD ECCCCCCCCCCCCCC	42.52	22817900
691	Ubiquitination	FAGDDAPRAVFPSIV CCCCCCCHHHCCHHC	45.14	22817900
715	Phosphorylation	GGMHQKESYVGKEAQ CCCCCCCCCCCHHHH	31.96	29978859
716	Phosphorylation	GMHQKESYVGKEAQS CCCCCCCCCCHHHHC	17.82	29978859
723	Phosphorylation	YVGKEAQSKRGILTL CCCHHHHCCCCEEEE	31.22	29978859
729	Phosphorylation	QSKRGILTLKYPMEH HCCCCEEEEECCCHH	21.20	23403867
731	Methylation	KRGILTLKYPMEHGI CCCEEEEECCCHHCC	41.91	-
732	Phosphorylation	RGILTLKYPMEHGII CCEEEEECCCHHCCC	15.78	-
740	Phosphorylation	PMEHGIITNWDDMEK CCHHCCCCCHHHHHH	28.47	22817900
747	Sumoylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
747	Ubiquitination	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	22817900
752	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	27273156
754	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	27273156
757	Ubiquitination	HHTFYNELRVAPEEH HHHHHCCCCCCCCCC	4.80	22817900
769	Phosphorylation	EEHPILLTEAPLNPK CCCCEEEEECCCCCC	27.01	-
776	Ubiquitination	TEAPLNPKANREKMT EECCCCCCCCHHHHH	58.16	27667366
781	Ubiquitination	NPKANREKMTQIMFE CCCCCHHHHHHHHHH	43.97	22817900
783	Phosphorylation	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	-
786	Ubiquitination	REKMTQIMFETFNTP HHHHHHHHHHHCCCH	1.46	22817900
789	Phosphorylation	MTQIMFETFNTPAMY HHHHHHHHCCCHHHH	15.77	28188228
791	Ubiquitination	QIMFETFNTPAMYVA HHHHHHCCCHHHHHH	53.20	22817900
796	Phosphorylation	TFNTPAMYVAIQAML HCCCHHHHHHHHHHH	6.71	28188228
804	Phosphorylation	VAIQAMLSLYTSGRT HHHHHHHHHHHCCCC	13.27	24719451
810	Methylation	LSLYTSGRTTGIVMD HHHHHCCCCEEEEEE	28.96	-
818	Phosphorylation	TTGIVMDSGDGVTHT CEEEEEECCCCCEEE	22.23	30140170
838	Phosphorylation	GNALPHATLRLDLAG CCCCCCEEEEEECCC	14.91	-
849	Phosphorylation	DLAGRELTDYLMKIL ECCCHHHHHHHHHHH	20.18	25072903
851	Phosphorylation	AGRELTDYLMKILTE CCHHHHHHHHHHHHH	11.94	25072903
854	Ubiquitination	ELTDYLMKILTERGY HHHHHHHHHHHHCCC	31.78	22817900
864	Phosphorylation	TERGYRFTTMAEREI HHCCCCCCCHHHHHH	13.48	23403867
864	Ubiquitination	TERGYRFTTMAEREI HHCCCCCCCHHHHHH	13.48	22817900
865	Phosphorylation	ERGYRFTTMAEREIV HCCCCCCCHHHHHHH	16.21	23403867
876	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	18526249
876	Ubiquitination	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	22817900
878	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHHEEECC	38.56	22817900
881	Phosphorylation	DIKEKLCYVALDFEQ HHHHHHHEEECCHHH	10.13	26657352
886	Ubiquitination	LCYVALDFEQEMAMV HHEEECCHHHHHHHH	12.42	22817900
888	Ubiquitination	YVALDFEQEMAMVAS EEECCHHHHHHHHHC	45.84	22817900
898	Phosphorylation	AMVASSSSLEKSYEL HHHHCCCCCCCEEEC	42.36	29457462
901	Ubiquitination	ASSSSLEKSYELPDG HCCCCCCCEEECCCC	64.73	22817900
902	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCCEEECCCCC	17.92	20068231
903	Phosphorylation	SSSLEKSYELPDGQV CCCCCCEEECCCCCE	32.33	20886841
911	Ubiquitination	ELPDGQVITISNEWF ECCCCCEEEECCCEE	1.86	22817900
934	Phosphorylation	PCFLGMESCGIHETT CCCCCHHHCCCCHHH	14.57	27251275
940	Phosphorylation	ESCGIHETTFNSIMK HHCCCCHHHHHHHHH	23.64	30140170
941	Phosphorylation	SCGIHETTFNSIMKS HCCCCHHHHHHHHHC	20.17	30140170
948	Phosphorylation	TFNSIMKSDVDIRKD HHHHHHHCCCCCCHH	26.03	-
954	Sumoylation	KSDVDIRKDLYTNTV HCCCCCCHHHCCCCE	53.04	-
957	Phosphorylation	VDIRKDLYTNTVLSG CCCCHHHCCCCEECC	14.21	18083107
960	Phosphorylation	RKDLYTNTVLSGGTT CHHHCCCCEECCCCC	18.28	20068231
963	Phosphorylation	LYTNTVLSGGTTMYP HCCCCEECCCCCCCC	30.73	20068231
966	Phosphorylation	NTVLSGGTTMYPGMA CCEECCCCCCCCCHH	16.35	20068231
967	Phosphorylation	TVLSGGTTMYPGMAH CEECCCCCCCCCHHH	20.27	20068231
969	Phosphorylation	LSGGTTMYPGMAHRM ECCCCCCCCCHHHHH	8.44	19534553
1022	Ubiquitination	FQQMWISKQEYDESG HHHHHHHCCCCCCCC	37.71	-
1025	Phosphorylation	MWISKQEYDESGPSI HHHHCCCCCCCCCCC	23.63	23401153
1028	Phosphorylation	SKQEYDESGPSIVHR HCCCCCCCCCCCCCC	53.78	23401153
1031	Phosphorylation	EYDESGPSIVHRKCF CCCCCCCCCCCCCCC	40.54	30266825
1036	Neddylation	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	32015554
1036	Ubiquitination	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POTEJ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POTEJ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POTEJ_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of POTEJ_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.