| UniProt ID | TPTE_HUMAN | |
|---|---|---|
| UniProt AC | P56180 | |
| Protein Name | Putative tyrosine-protein phosphatase TPTE | |
| Gene Name | TPTE | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 551 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Could be involved in signal transduction.. | |
| Protein Sequence | MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSPISESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVKTPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Phosphorylation | IELGPNDSPQTSEFK EECCCCCCCCCCCCC | 26.08 | 25693802 | |
| 25 | Phosphorylation | GPNDSPQTSEFKGAT CCCCCCCCCCCCCCC | 33.34 | 25693802 | |
| 26 | Phosphorylation | PNDSPQTSEFKGATE CCCCCCCCCCCCCCC | 35.47 | 25693802 | |
| 32 | Phosphorylation | TSEFKGATEEAPAKE CCCCCCCCCCCCCCC | 42.92 | - | |
| 40 | Phosphorylation | EEAPAKESPHTSEFK CCCCCCCCCCCHHCC | 22.67 | - | |
| 41 (in isoform 3) | Phosphorylation | - | 35.55 | - | |
| 53 | Phosphorylation | FKGAARVSPISESVL CCCCCCCCCCCHHHH | 15.80 | 30619164 | |
| 56 | Phosphorylation | AARVSPISESVLARL CCCCCCCCHHHHHHH | 27.48 | 30619164 | |
| 58 | Phosphorylation | RVSPISESVLARLSK CCCCCCHHHHHHHHC | 18.68 | 30619164 | |
| 64 | Phosphorylation | ESVLARLSKFEVEDA HHHHHHHHCCCCCCH | 29.73 | 30619164 | |
| 191 | Phosphorylation | LRNIPRWTHLLRLLR HHCCCHHHHHHHHHH | 12.15 | - | |
| 422 | Phosphorylation | FIKHFIIYSIPRYVR EEEEHHHHHCHHHHH | 8.84 | - | |
| 427 | Phosphorylation | IIYSIPRYVRDLKIQ HHHHCHHHHHHCCCE | 8.42 | - | |
| 439 | Ubiquitination | KIQIEMEKKVVFSTI CCEEEEEECEEEEEE | 49.94 | - | |
| 509 | Phosphorylation | FIENNRLYLPKNELD HHHCCEEECCHHHHH | 20.09 | - | |
| 550 | Phosphorylation | SSDVVAGSD------ CCCCCCCCC------ | 30.34 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPTE_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPTE_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPTE_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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