dbPTM

STX18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STX18_HUMAN
UniProt AC	Q9P2W9
Protein Name	Syntaxin-18
Gene Name	STX18
Organism	Homo sapiens (Human).
Sequence Length	335
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type IV membrane protein . Golgi apparatus membrane Single-pass type IV membrane protein .
Protein Description	Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER..
Protein Sequence	MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LFRASVKTVKTRNKA EEEHHCCCHHHCCCC	25.69	22210691
18	Phosphorylation	ASVKTVKTRNKALGV HHCCCHHHCCCCCCE	34.83	22210691
21	Ubiquitination	KTVKTRNKALGVAVG CCHHHCCCCCCEEEC	41.52	-
34	Phosphorylation	VGGGVDGSRDELFRR ECCCCCCCHHHHHHC	31.90	22210691
39	Ubiquitination	DGSRDELFRRSPRPK CCCHHHHHHCCCCCC	6.00	29967540
42	Phosphorylation	RDELFRRSPRPKGDF HHHHHHCCCCCCCCC	22.47	17081983
46	Ubiquitination	FRRSPRPKGDFSSRA HHCCCCCCCCCHHHH	72.84	29967540
47	Ubiquitination	RRSPRPKGDFSSRAR HCCCCCCCCCHHHHH	43.83	29967540
50	Phosphorylation	PRPKGDFSSRAREVI CCCCCCCHHHHHHHH	24.53	23403867
51	Phosphorylation	RPKGDFSSRAREVIS CCCCCCHHHHHHHHH	29.92	23403867
62	Ubiquitination	EVISHIGKLRDFLLE HHHHHHHHHHHHHHH	39.48	21963094
66	Ubiquitination	HIGKLRDFLLEHRKD HHHHHHHHHHHHCHH	7.29	22817900
72	Ubiquitination	DFLLEHRKDYINAYS HHHHHHCHHHHHHHH	57.71	-
81	Phosphorylation	YINAYSHTMSEYGRM HHHHHHCHHHHHCCC	19.22	28555341
83	Phosphorylation	NAYSHTMSEYGRMTD HHHHCHHHHHCCCCC	28.90	28857561
85	Phosphorylation	YSHTMSEYGRMTDTE HHCHHHHHCCCCCCC	11.61	-
87	Ubiquitination	HTMSEYGRMTDTERD CHHHHHCCCCCCCHH	24.75	29967540
91	Phosphorylation	EYGRMTDTERDQIDQ HHCCCCCCCHHHHHH	24.61	-
95	Ubiquitination	MTDTERDQIDQDAQI CCCCCHHHHHHHHHH	47.59	24816145
108	Phosphorylation	QIFMRTCSEAIQQLR HHHHHHHHHHHHHHH	29.47	33259812
120	Ubiquitination	QLRTEAHKEIHSQQV HHHHHHHHHHHHHHH	66.47	29967540
125	Ubiquitination	AHKEIHSQQVKEHRT HHHHHHHHHHHHHHH	37.61	29967540
126	Ubiquitination	HKEIHSQQVKEHRTA HHHHHHHHHHHHHHH	51.79	27667366
128	Ubiquitination	EIHSQQVKEHRTAVL HHHHHHHHHHHHHHH	43.39	29967540
141	Phosphorylation	VLDFIEDYLKRVCKL HHHHHHHHHHHHHHH	11.00	28111955
143	Ubiquitination	DFIEDYLKRVCKLYS HHHHHHHHHHHHHHH	36.23	21963094
147	Ubiquitination	DYLKRVCKLYSEQRA HHHHHHHHHHHHHHH	47.83	22817900
149	Phosphorylation	LKRVCKLYSEQRAIR HHHHHHHHHHHHHHH	8.82	29496907
167	Phosphorylation	VVDKKRLSKLEPEPN ECCHHHHHHCCCCCC	38.95	26657352
168	Ubiquitination	VDKKRLSKLEPEPNT CCHHHHHHCCCCCCC	62.55	29967540
175	Phosphorylation	KLEPEPNTKTRESTS HCCCCCCCCCCCCCC	44.50	28122231
176	Ubiquitination	LEPEPNTKTRESTSS CCCCCCCCCCCCCCC	52.83	24816145
180	Phosphorylation	PNTKTRESTSSEKVS CCCCCCCCCCCCCCC	30.23	23312004
181	Phosphorylation	NTKTRESTSSEKVSQ CCCCCCCCCCCCCCC	31.36	23312004
182	Phosphorylation	TKTRESTSSEKVSQS CCCCCCCCCCCCCCC	45.86	23312004
183	Phosphorylation	KTRESTSSEKVSQSP CCCCCCCCCCCCCCC	41.34	29214152
187	Phosphorylation	STSSEKVSQSPSKDS CCCCCCCCCCCCCCC	35.69	29255136
189	Phosphorylation	SSEKVSQSPSKDSEE CCCCCCCCCCCCCCC	24.51	23401153
191	Phosphorylation	EKVSQSPSKDSEENP CCCCCCCCCCCCCCC	55.10	29255136
194	Phosphorylation	SQSPSKDSEENPATE CCCCCCCCCCCCCCC	51.01	23927012
200	Phosphorylation	DSEENPATEERPEKI CCCCCCCCCCCHHHH	39.37	23927012
206	Ubiquitination	ATEERPEKILAETQP CCCCCHHHHHHHCCC	45.78	29967540
207	Ubiquitination	TEERPEKILAETQPE CCCCHHHHHHHCCCC	4.14	27667366
215	Ubiquitination	LAETQPELGTWGDGK HHHCCCCCCCCCCCC	10.62	22817900
246	Ubiquitination	NQRLIGEMNSLFDEV HHHHHHHHHHHHHHH	3.30	22817900
248	Phosphorylation	RLIGEMNSLFDEVRQ HHHHHHHHHHHHHHH	29.15	24173317
264	Phosphorylation	EGRVVEISRLQEIFT HCCEEEHHHHHHHHH	17.27	-
271	Phosphorylation	SRLQEIFTEKVLQQE HHHHHHHHHHHHHHH	40.32	-
294	Ubiquitination	LVVGATENIKEGNED HHHHCCCCHHCCCHH	46.40	22817900
296	Ubiquitination	VGATENIKEGNEDIR HHCCCCHHCCCHHHH	71.76	22817900
327	Ubiquitination	LVMCSFSLLFLDWYD HHHHHHHHHHHHHCC	3.55	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STX18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STX18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STX18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZW10_HUMAN	ZW10	physical	15029241
RINT1_HUMAN	RINT1	physical	15029241
SNP23_HUMAN	SNAP23	physical	15029241
SCFD1_HUMAN	SCFD1	physical	15029241
SC22B_HUMAN	SEC22B	physical	15029241
SC22B_HUMAN	SEC22B	physical	26186194
SEC20_HUMAN	BNIP1	physical	26186194
RTL6_HUMAN	LDOC1L	physical	26186194
ZW10_HUMAN	ZW10	physical	26186194
NBAS_HUMAN	NBAS	physical	26186194
STX5_HUMAN	STX5	physical	26186194
FUT8_HUMAN	FUT8	physical	26186194
SNP47_HUMAN	SNAP47	physical	26186194
SCFD1_HUMAN	SCFD1	physical	26186194
VAMP4_HUMAN	VAMP4	physical	26186194
STX8_HUMAN	STX8	physical	26186194
BET1_HUMAN	BET1	physical	26186194
VAMP8_HUMAN	VAMP8	physical	26186194
NBAS_HUMAN	NBAS	physical	28514442
RTL6_HUMAN	LDOC1L	physical	28514442
VAMP8_HUMAN	VAMP8	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
BET1_HUMAN	BET1	physical	28514442
STX8_HUMAN	STX8	physical	28514442
SNP47_HUMAN	SNAP47	physical	28514442
STX5_HUMAN	STX5	physical	28514442
ZW10_HUMAN	ZW10	physical	28514442
BET1L_HUMAN	BET1L	physical	28514442
FUT8_HUMAN	FUT8	physical	28514442
SCFD1_HUMAN	SCFD1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STX18_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, AND MASSSPECTROMETRY.	19413330 [Abstract]