STX5_HUMAN - dbPTM
STX5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STX5_HUMAN
UniProt AC Q13190
Protein Name Syntaxin-5
Gene Name STX5
Organism Homo sapiens (Human).
Sequence Length 355
Subcellular Localization Endoplasmic reticulum-Golgi intermediate compartment membrane
Single-pass type IV membrane protein . Golgi apparatus membrane . Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae.
Protein Description Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus..
Protein Sequence MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAGSSSSDIAPLPPPVTLVPPPPDTMSCRDRTQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSALPLAPNHLGGGAVVLGAESHASKDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MIPRKRYGSKNTDQ
-CCCCCCCCCCCCCC		28.8726657352
9PhosphorylationIPRKRYGSKNTDQGV
CCCCCCCCCCCCCCE		17.5023401153
12PhosphorylationKRYGSKNTDQGVYLG
CCCCCCCCCCCEEEC		33.1726657352
17PhosphorylationKNTDQGVYLGLSKTQ
CCCCCCEEECCCCCE		11.2421945579
21PhosphorylationQGVYLGLSKTQVLSP
CCEEECCCCCEEECC		31.6821945579
23PhosphorylationVYLGLSKTQVLSPAT
EEECCCCCEEECCCC		22.1226503514
27PhosphorylationLSKTQVLSPATAGSS
CCCCEEECCCCCCCC		17.4026503514
30PhosphorylationTQVLSPATAGSSSSD
CEEECCCCCCCCCCC		34.6326503514
33PhosphorylationLSPATAGSSSSDIAP
ECCCCCCCCCCCCCC		25.2826503514
61PhosphorylationTMSCRDRTQEFLSAC
CCCCHHHHHHHHHHH		36.42-
66PhosphorylationDRTQEFLSACKSLQT
HHHHHHHHHHHHHHH		36.6221712546
69UbiquitinationQEFLSACKSLQTRQN
HHHHHHHHHHHHHHH		54.65-
82UbiquitinationQNGIQTNKPALRAVR
HHCCCCCHHHHHHHH		34.75-
92PhosphorylationLRAVRQRSEFTLMAK
HHHHHHHHHHHHHHH		28.8223312004
94 (in isoform 2)Ubiquitination-7.2021906983
95PhosphorylationVRQRSEFTLMAKRIG
HHHHHHHHHHHHHHC		16.1523312004
99MalonylationSEFTLMAKRIGKDLS
HHHHHHHHHHCCCCH		30.5026320211
992-HydroxyisobutyrylationSEFTLMAKRIGKDLS
HHHHHHHHHHCCCCH		30.50-
99UbiquitinationSEFTLMAKRIGKDLS
HHHHHHHHHHCCCCH		30.50-
103UbiquitinationLMAKRIGKDLSNTFA
HHHHHHCCCCHHHHH		53.80-
106PhosphorylationKRIGKDLSNTFAKLE
HHHCCCCHHHHHHHH		43.9130622161
108PhosphorylationIGKDLSNTFAKLEKL
HCCCCHHHHHHHHHH		22.9230622161
111UbiquitinationDLSNTFAKLEKLTIL
CCHHHHHHHHHHHHH		53.65-
114UbiquitinationNTFAKLEKLTILAKR
HHHHHHHHHHHHHHC		62.46-
120UbiquitinationEKLTILAKRKSLFDD
HHHHHHHHCHHCCCC		57.84-
1202-HydroxyisobutyrylationEKLTILAKRKSLFDD
HHHHHHHHCHHCCCC		57.84-
122UbiquitinationLTILAKRKSLFDDKA
HHHHHHCHHCCCCCC		51.29-
123PhosphorylationTILAKRKSLFDDKAV
HHHHHCHHCCCCCCE		38.0028102081
128UbiquitinationRKSLFDDKAVEIEEL
CHHCCCCCCEEHHHH		57.06-
136PhosphorylationAVEIEELTYIIKQDI
CEEHHHHHHHHHHHH		18.8926270265
137PhosphorylationVEIEELTYIIKQDIN
EEHHHHHHHHHHHHH		17.1726270265
140UbiquitinationEELTYIIKQDINSLN
HHHHHHHHHHHHHHH		32.15-
148 (in isoform 3)Ubiquitination-48.6621906983
148 (in isoform 1)Ubiquitination-48.6621906983
148UbiquitinationQDINSLNKQIAQLQD
HHHHHHHHHHHHHHH		48.662190698
185PhosphorylationSLQSKLASMSNDFKS
EHHHHHHHCCCCHHH		32.9325690035
202UbiquitinationEVRTENLKQQRSRRE
HHHHHHHHHHHHHHH		56.84-
237PhosphorylationAVVLGAESHASKDVA
EEEECCCCCCCCCEE		24.6628348404
240PhosphorylationLGAESHASKDVAIDM
ECCCCCCCCCEEHHH		24.7828348404
247SulfoxidationSKDVAIDMMDSRTSQ
CCCEEHHHCCCCCHH		2.3530846556
248SulfoxidationKDVAIDMMDSRTSQQ
CCEEHHHCCCCCHHH		3.6230846556
250PhosphorylationVAIDMMDSRTSQQLQ
EEHHHCCCCCHHHHH		21.4028674419
252PhosphorylationIDMMDSRTSQQLQLI
HHHCCCCCHHHHHHH		34.5327251275
253PhosphorylationDMMDSRTSQQLQLID
HHCCCCCHHHHHHHH		18.1529396449
264PhosphorylationQLIDEQDSYIQSRAD
HHHHHHHHHHHHHHH		24.6726055452
265PhosphorylationLIDEQDSYIQSRADT
HHHHHHHHHHHHHHH		15.9821712546
268PhosphorylationEQDSYIQSRADTMQN
HHHHHHHHHHHHHHH		21.6328796482
300PhosphorylationMVKEQEETIQRIDEN
HHHHHHHHHHHHHHH		22.9721815630
324UbiquitinationAAHSEILKYFQSVTS
HHHHHHHHHHHHHCC		50.08-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STX5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STX5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STX5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNAA_HUMANNAPAphysical
16189514
SC22B_HUMANSEC22Bphysical
15029241
SNP23_HUMANSNAP23physical
12651853
VAPB_HUMANVAPBphysical
12651853
APLP1_HUMANAPLP1physical
16169070
CSN6_HUMANCOPS6physical
16169070
MIC60_HUMANIMMTphysical
16169070
LRIF1_HUMANLRIF1physical
16169070
BAG6_HUMANBAG6physical
16169070
HAP1_HUMANHAP1physical
16169070
P53_HUMANTP53physical
16169070
GOSR1_HUMANGOSR1physical
9094723
GOSR2_HUMANGOSR2physical
9094723
STX17_HUMANSTX17physical
9094723
GOSR1_HUMANGOSR1physical
11927603
YKT6_HUMANYKT6physical
11927603
SC22A_HUMANSEC22Aphysical
11927603
GOSR2_HUMANGOSR2physical
11927603
BET1L_HUMANBET1Lphysical
11927603
BET1_HUMANBET1physical
11927603
VTI1B_HUMANVTI1Bphysical
11927603
GOSR1_HUMANGOSR1physical
9325254
NSF1C_HUMANNSFL1Cphysical
9506515
SNAA_HUMANNAPAphysical
9506515
VCIP1_HUMANVCPIP1physical
12473691
TACC1_HUMANTACC1physical
25416956
SNAB_HUMANNAPBphysical
25416956
KASH5_HUMANCCDC155physical
25416956
RBM26_HUMANRBM26physical
26186194
HMMR_HUMANHMMRphysical
26186194
FP100_HUMANC17orf70physical
26186194
TNPO3_HUMANTNPO3physical
26186194
SCFD1_HUMANSCFD1physical
26186194
FP100_HUMANC17orf70physical
28514442
TNPO3_HUMANTNPO3physical
28514442
HMMR_HUMANHMMRphysical
28514442
SCFD1_HUMANSCFD1physical
28514442
TACC1_HUMANTACC1physical
28514442
ACADS_HUMANACADSphysical
28514442
RBM26_HUMANRBM26physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STX5_HUMAN

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Related Literatures of Post-Translational Modification

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