ACADS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACADS_HUMAN
• UniProt AC: P16219
• Protein Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
• Gene Name: ACADS
• Organism: Homo sapiens (Human).
• Sequence Length: 412
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms..
• Protein Sequence: MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AALLARASGPARRAL HHHHHHHHCHHHHHH	39.49	24719451
27	Phosphorylation	RAWRQLHTIYQSVEL HHHHHHHHHHHCCCC	29.94	-
51	Succinylation	TCRDFAEKELFPIAA HHHHHHHHCHHCHHH	57.18	-
51	Succinylation	TCRDFAEKELFPIAA HHHHHHHHCHHCHHH	57.18	-
51	Acetylation	TCRDFAEKELFPIAA HHHHHHHHCHHCHHH	57.18	25038526
72	Acetylation	LFPAAQVKKMGGLGL CCCHHHHHHCCCCCE	25.59	2418873
95	Phosphorylation	LGGAGLDYLAYAIAM HCCCCHHHHHHHHHH	9.77	24043423
98	Phosphorylation	AGLDYLAYAIAMEEI CCHHHHHHHHHHHHH	8.92	24043423
106	Phosphorylation	AIAMEEISRGCASTG HHHHHHHHCCCCCCC	26.37	24043423
121	Phosphorylation	VIMSVNNSLYLGPIL EEEEECCEEECCCCC	17.12	46157401
129	Succinylation	LYLGPILKFGSKEQK EECCCCCCCCCHHHH	48.69	-
129	Succinylation	LYLGPILKFGSKEQK EECCCCCCCCCHHHH	48.69	-
129	Acetylation	LYLGPILKFGSKEQK EECCCCCCCCCHHHH	48.69	25038526
136	Acetylation	KFGSKEQKQAWVTPF CCCCHHHHHEEEECC	42.97	25038526
148	Acetylation	TPFTSGDKIGCFALS ECCCCCCEEEEEEEC	44.52	25038526
208	Acetylation	TDRALQNKGISAFLV CCHHHHHCCCCEEEE	44.66	-
219	Phosphorylation	AFLVPMPTPGLTLGK EEEEECCCCCCCCCC	24.60	110741841
259	Sulfoxidation	SILGEPGMGFKIAMQ HCCCCCCCCHHHEEE	9.26	21406390
262	Acetylation	GEPGMGFKIAMQTLD CCCCCCHHHEEECCC	24.67	25038526
262	Succinylation	GEPGMGFKIAMQTLD CCCCCCHHHEEECCC	24.67	-
262	Succinylation	GEPGMGFKIAMQTLD CCCCCCHHHEEECCC	24.67	-
265	Sulfoxidation	GMGFKIAMQTLDMGR CCCHHHEEECCCCCC	3.40	21406390
305	Phosphorylation	MAFGAPLTKLQVIQF CCCCCCCCHHHHHHH	28.75	35103603
306	Succinylation	AFGAPLTKLQVIQFK CCCCCCCHHHHHHHH	44.60	-
306	Acetylation	AFGAPLTKLQVIQFK CCCCCCCHHHHHHHH	44.60	27178108
306	Succinylation	AFGAPLTKLQVIQFK CCCCCCCHHHHHHHH	44.60	-
306	Ubiquitination	AFGAPLTKLQVIQFK CCCCCCCHHHHHHHH	44.60	-
317	Sulfoxidation	IQFKLADMALALESA HHHHHHHHHHHHHHH	2.47	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACADS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACADS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
219	Phosphorylation	209 (10)	G ⇒ S	rs1799958	Serum metabolite ratios in chronic kidney disease	29545352

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRF7_HUMAN	IRF7	physical	21988832
CLIC4_HUMAN	CLIC4	physical	26344197
DPEP1_HUMAN	DPEP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 201470: Acyl-CoA dehydrogenase short-chain deficiency (ACADSD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB03147: Flavin adenine dinucleotide