SC22A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC22A_HUMAN
• UniProt AC: Q96IW7
• Protein Name: Vesicle-trafficking protein SEC22a
• Gene Name: SEC22A
• Organism: Homo sapiens (Human).
• Sequence Length: 307
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: May be involved in vesicle transport between the ER and the Golgi complex..
• Protein Sequence: MSMILSASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRTKQRYNNPRSLSTKINLSDMQTEIKLRPPYQISMCELGSANGVTSAFSVDCKGAGKISSAHQRLEPATLSGIVGFILSLLCGALNLIRGFHAIESLLQSDGDDFNYIIAFFLGTAACLYQCYLLVYYTGWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQIWLRQAQGKAPDYDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSMILSASV ------CCCEEEEEE	17.96	22814378
2	Phosphorylation	------MSMILSASV ------CCCEEEEEE	17.96	22617229
6	Phosphorylation	--MSMILSASVIRVR --CCCEEEEEEEEEC	13.94	18669648
8	Phosphorylation	MSMILSASVIRVRDG CCCEEEEEEEEECCC	18.07	18669648
36	Phosphorylation	GMQECRKYFKMLSRK CHHHHHHHHHHHHHH	6.78	-
41	Phosphorylation	RKYFKMLSRKLAQLP HHHHHHHHHHHHCCC	24.70	24719451
43	Ubiquitination	YFKMLSRKLAQLPDR HHHHHHHHHHCCCCC	44.81	29967540
98	Phosphorylation	QKEFITTYNMMKTNT HHHHHHHHHHHCCCC	7.75	-
134	Phosphorylation	NNPRSLSTKINLSDM CCCCCCCCEECHHHC	41.03	-
135	Ubiquitination	NPRSLSTKINLSDMQ CCCCCCCEECHHHCC	26.65	29967540
139	Phosphorylation	LSTKINLSDMQTEIK CCCEECHHHCCCEEE	26.92	-
143	Phosphorylation	INLSDMQTEIKLRPP ECHHHCCCEEECCCC	32.80	-
154	Phosphorylation	LRPPYQISMCELGSA CCCCCEEEEEECCCC	11.23	28787133
160	Phosphorylation	ISMCELGSANGVTSA EEEEECCCCCCCCEE	31.05	28787133
166	Phosphorylation	GSANGVTSAFSVDCK CCCCCCCEEEEEECC	25.55	28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC22A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC22A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC22A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMM79_HUMAN	TMEM79	physical	25416956
FATE1_HUMAN	FATE1	physical	25416956
DTX2_HUMAN	DTX2	physical	25416956
SYNE4_HUMAN	SYNE4	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-8, AND MASSSPECTROMETRY.
PubMed: 18669648