SYNE4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYNE4_HUMAN
• UniProt AC: Q8N205
• Protein Name: Nesprin-4
• Gene Name: SYNE4
• Organism: Homo sapiens (Human).
• Sequence Length: 404
• Subcellular Localization: Nucleus outer membrane ; Single-pass type IV membrane protein . Localization at the nucleus outer membrane requires the presence of SUN1..
• Protein Description: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)..
• Protein Sequence: MALSLPLGPRLGSEPLNHPPGAPREADIVGCTVCPASGEESTSPEQAQTLGQDSLGPPEHFQGGPRGNEPAAHPPRWSTPSSYEDPAGGKHCEHPISGLEVLEAEQNSLHLCLLGLGRRLQDLEQGLGHWALAQSGMVQLQALQVDLRGAAERVEALLAFGEGLAQRSEPRAWAALEQILRALGAYRDSIFRRLWQLQAQLVSYSLVFEEANTLDQDLEVEGDSDWPGPGGVWGPWAPSSLPTSTELEWDPAGDIGGLGPLGQKTARTLGVPCELCGQRGPQGRGQGLEEADTSHSRQDMLESGLGHQKRLARHQRHSLLRKPQDKKRQASPHLQDVRLEGNPGAPDPASRQPLTFLLILFLLFLLLVGAMFLLPASGGPCCSHARIPRTPYLVLSYVNGLPPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MALSLPLGPRL ----CCCCCCCCCCC	20.57	23403867
135	Phosphorylation	GHWALAQSGMVQLQA HHHHHHHHCCEEEEE	24.21	68729333
303	Phosphorylation	SRQDMLESGLGHQKR HHHHHHHHCCHHHHH	35.04	46160885
318	Phosphorylation	LARHQRHSLLRKPQD HHHHHHHHHHCCHHH	31.15	54886417
331	Phosphorylation	QDKKRQASPHLQDVR HHHCCCCCCCHHHCC	12.43	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYNE4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYNE4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYNE4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CJ035_HUMAN	C10orf35	physical	25416956
DB121_HUMAN	DEFB121	physical	25416956
BRID5_HUMAN	BRICD5	physical	25416956
ADCY6_HUMAN	ADCY6	physical	26186194
VAPB_HUMAN	VAPB	physical	26186194
EXTL3_HUMAN	EXTL3	physical	26186194
OCLN_HUMAN	OCLN	physical	26186194
CNDH2_HUMAN	NCAPH2	physical	26186194
CGAT2_HUMAN	CSGALNACT2	physical	26186194
FZD2_HUMAN	FZD2	physical	26186194
LEMD2_HUMAN	LEMD2	physical	26186194
FZD6_HUMAN	FZD6	physical	26186194
TM192_HUMAN	TMEM192	physical	26186194
ZFPL1_HUMAN	ZFPL1	physical	26186194
TM39A_HUMAN	TMEM39A	physical	26186194
POMT1_HUMAN	POMT1	physical	26186194
ZDHC9_HUMAN	ZDHHC9	physical	26186194
KEAP1_HUMAN	KEAP1	physical	26186194
B3GT6_HUMAN	B3GALT6	physical	26186194
XYLK_HUMAN	FAM20B	physical	26186194
FZD3_HUMAN	FZD3	physical	26186194
TUSC3_HUMAN	TUSC3	physical	26186194
TM231_HUMAN	TMEM231	physical	26186194
LSR_HUMAN	LSR	physical	26186194
KLC1_HUMAN	KLC1	physical	26186194
KLC3_HUMAN	KLC3	physical	26186194
KLC2_HUMAN	KLC2	physical	26186194
KLC4_HUMAN	KLC4	physical	26186194
GPC5C_HUMAN	GPRC5C	physical	26186194
DJC11_HUMAN	DNAJC11	physical	26186194
SNG2_HUMAN	SYNGR2	physical	26186194
GOLI4_HUMAN	GOLIM4	physical	26186194
AP1G2_HUMAN	AP1G2	physical	26186194
KIF5C_HUMAN	KIF5C	physical	26186194
KINH_HUMAN	KIF5B	physical	26186194
KIF5A_HUMAN	KIF5A	physical	26186194
MAN1_HUMAN	LEMD3	physical	26186194
SMC2_HUMAN	SMC2	physical	26186194
TMTC3_HUMAN	TMTC3	physical	26186194
SARAF_HUMAN	SARAF	physical	26186194
CNDD3_HUMAN	NCAPD3	physical	26186194
SPP2B_HUMAN	SPPL2B	physical	26186194
EXT1_HUMAN	EXT1	physical	26186194
DSE_HUMAN	DSE	physical	26186194
FKRP_HUMAN	FKRP	physical	26186194
CLC7A_HUMAN	CLEC7A	physical	21516116
KLC3_HUMAN	KLC3	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
KLC4_HUMAN	KLC4	physical	28514442
KLC1_HUMAN	KLC1	physical	28514442
KIF5A_HUMAN	KIF5A	physical	28514442
KIF5C_HUMAN	KIF5C	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
KINH_HUMAN	KIF5B	physical	28514442
ZFPL1_HUMAN	ZFPL1	physical	28514442
FZD3_HUMAN	FZD3	physical	28514442
AP1G2_HUMAN	AP1G2	physical	28514442
DSE_HUMAN	DSE	physical	28514442
FZD6_HUMAN	FZD6	physical	28514442
TM231_HUMAN	TMEM231	physical	28514442
FKRP_HUMAN	FKRP	physical	28514442
OCLN_HUMAN	OCLN	physical	28514442
SARAF_HUMAN	SARAF	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
TUSC3_HUMAN	TUSC3	physical	28514442
EXT1_HUMAN	EXT1	physical	28514442
B3GT6_HUMAN	B3GALT6	physical	28514442
CNDH2_HUMAN	NCAPH2	physical	28514442
LSR_HUMAN	LSR	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
SMC2_HUMAN	SMC2	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
CGAT2_HUMAN	CSGALNACT2	physical	28514442
CNDD3_HUMAN	NCAPD3	physical	28514442
KEAP1_HUMAN	KEAP1	physical	28514442
SPP2B_HUMAN	SPPL2B	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.