SNG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNG2_HUMAN
• UniProt AC: O43760
• Protein Name: Synaptogyrin-2 {ECO:0000305}
• Gene Name: SYNGR2 {ECO:0000312|HGNC:HGNC:11499}
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Localizes to cytoplasmic vesicles associated with the recycling endosomes.; Lipid droplet.
• Protein Description: May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.; (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication..
• Protein Sequence: MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIYGEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWGVLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESGAYGA -------CCCCCCCC	9.26	22223895
3	Phosphorylation	-----MESGAYGAAK -----CCCCCCCCHH	27.68	23401153
6	Phosphorylation	--MESGAYGAAKAGG --CCCCCCCCHHCCC	15.72	27259358
10	Ubiquitination	SGAYGAAKAGGSFDL CCCCCCHHCCCCCCH	47.21	21890473
14	Phosphorylation	GAAKAGGSFDLRRFL CCHHCCCCCCHHHHH	18.05	25850435
181	Phosphorylation	VDDFIQNYVDPTPDP HHHHHHHCCCCCCCC	7.00	-
194	Phosphorylation	DPNTAYASYPGASVD CCCCCCCCCCCCCCC	21.13	-
203	Phosphorylation	PGASVDNYQQPPFTQ CCCCCCCCCCCCCCC	12.22	22817900
218	Phosphorylation	NAETTEGYQPPPVY- CCCCCCCCCCCCCC-	16.18	22817900
224	Phosphorylation	GYQPPPVY------- CCCCCCCC-------	20.71	20736484

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCAR3_HUMAN	SCARA3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-3, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-3, AND MASS SPECTROMETRY.
PubMed: 19413330