| UniProt ID | B3GT6_HUMAN | |
|---|---|---|
| UniProt AC | Q96L58 | |
| Protein Name | Beta-1,3-galactosyltransferase 6 | |
| Gene Name | B3GALT6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 329 | |
| Subcellular Localization |
Golgi apparatus, Golgi stack membrane Single-pass type II membrane protein . |
|
| Protein Description | Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.. | |
| Protein Sequence | MKLLRRAWRRRAALGLGTLALCGAALLYLARCAAEPGDPRAMSGRSPPPPAPARAAAFLAVLVASAPRAAERRSVIRSTWLARRGAPGDVWARFAVGTAGLGAEERRALEREQARHGDLLLLPALRDAYENLTAKVLAMLAWLDEHVAFEFVLKADDDSFARLDALLAELRAREPARRRRLYWGFFSGRGRVKPGGRWREAAWQLCDYYLPYALGGGYVLSADLVHYLRLSRDYLRAWHSEDVSLGAWLAPVDVQREHDPRFDTEYRSRGCSNQYLVTHKQSLEDMLEKHATLAREGRLCKREVQLRLSYVYDWSAPPSQCCQRREGIP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | O-linked_Glycosylation | PRAMSGRSPPPPAPA CCCCCCCCCCCCCHH | 45.33 | OGP | |
| 65 | Phosphorylation | FLAVLVASAPRAAER HHHHHHHCCCCHHHH | 31.18 | - | |
| 79 | Phosphorylation | RRSVIRSTWLARRGA HHHHHHHHHHHHCCC | 18.04 | 30576142 | |
| 129 | Phosphorylation | LPALRDAYENLTAKV HHHHHHHHHHHHHHH | 15.05 | - | |
| 131 | N-linked_Glycosylation | ALRDAYENLTAKVLA HHHHHHHHHHHHHHH | 29.98 | UniProtKB CARBOHYD | |
| 133 | Phosphorylation | RDAYENLTAKVLAML HHHHHHHHHHHHHHH | 35.69 | - | |
| 280 | Ubiquitination | NQYLVTHKQSLEDML CCHHHHCHHHHHHHH | 32.01 | - | |
| 282 | Phosphorylation | YLVTHKQSLEDMLEK HHHHCHHHHHHHHHH | 38.23 | - | |
| 289 | Ubiquitination | SLEDMLEKHATLARE HHHHHHHHHHHHHHH | 34.28 | 29967540 | |
| 315 | O-linked_Glycosylation | LSYVYDWSAPPSQCC EEEEECCCCCHHHHC | 28.18 | OGP | |
| 319 | Phosphorylation | YDWSAPPSQCCQRRE ECCCCCHHHHCHHCC | 34.49 | 23401153 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of B3GT6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of B3GT6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of B3GT6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of B3GT6_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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