dbPTM

ZDHC9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZDHC9_HUMAN
UniProt AC	Q9Y397
Protein Name	Palmitoyltransferase ZDHHC9
Gene Name	ZDHHC9
Organism	Homo sapiens (Human).
Sequence Length	364
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein .
Protein Description	The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS..
Protein Sequence	MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQETSSSLLPQSPAPTEHLNSNEMPEDSSTPEEMPPPEPPEPPQEAAEAEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	AAMLFLFSMATLLRT HHHHHHHHHHHHHHH	15.06	-
82	Phosphorylation	LFLFSMATLLRTSFS HHHHHHHHHHHHHCC	20.06	-
127	Ubiquitination	QRPPPRIKNFQINNQ CCCCCCCEEEEECCE	53.65	22817900
137	Ubiquitination	QINNQIVKLKYCYTC EECCEEEEEEECEEC	40.67	29901268
139	Ubiquitination	NNQIVKLKYCYTCKI CCEEEEEEECEECCC	27.79	29901268
267	Ubiquitination	IKGSWTGKNRVQNPY CCCCCCCCCCCCCCC	33.92	29967540
281	Ubiquitination	YSHGNIVKNCCEVLC CCCCCHHHCHHHHHH	40.23	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZDHC9_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZDHC9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZDHC9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZDHC9_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00658	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabe
OMIM Disease
300799	Mental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZDHC9_HUMAN

Related Literatures of Post-Translational Modification