FZD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD3_HUMAN
• UniProt AC: Q9NPG1
• Protein Name: Frizzled-3
• Gene Name: FZD3
• Organism: Homo sapiens (Human).
• Sequence Length: 666
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface . Apical cell membrane ; Multi-pass membrane protein. Colocalizes with FZD6 at the apical face of the cell (By similarity).
• Protein Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity)..
• Protein Sequence: MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIEEDGTSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	MCQDLPYNTTFMPNL HCCCCCCCCCCCHHH	30.61	UniProtKB CARBOHYD
150	O-linked_Glycosylation	LNLAGEPTEGAPVAV ECCCCCCCCCCCEEE	42.63	OGP
170	Ubiquitination	FWCPRELKIDPDLGY EECCCCEECCCCCCC	40.07	-
178	Phosphorylation	IDPDLGYSFLHVRDC CCCCCCCCEEEEECC	21.38	-
265	N-linked_Glycosylation	LEDRVACNASIPAQY HCCHHHCCCCCCCCH	27.30	UniProtKB CARBOHYD
275	Phosphorylation	IPAQYKASTVTQGSH CCCCHHCCCCCCCCH	21.18	22210691
356	N-linked_Glycosylation	MNKIEGDNISGVCFV CHHCCCCCCCCEEEE	40.98	UniProtKB CARBOHYD
408	Ubiquitination	RIEIPLEKENQDKLV EEEEECCCCCHHHHH	70.42	33845483
535	Phosphorylation	QEPDFAQSLLRDPNT HCCHHHHHHHCCCCC	26.41	24719451
542	Phosphorylation	SLLRDPNTPIIRKSR HHHCCCCCCEEECCC	22.66	21815630
549	Methylation	TPIIRKSRGTSTQGT CCEEECCCCCCCCCC	56.28	-
551	Phosphorylation	IIRKSRGTSTQGTST EEECCCCCCCCCCCC	27.73	23312004
552	Phosphorylation	IRKSRGTSTQGTSTH EECCCCCCCCCCCCC	22.89	23312004
553	Phosphorylation	RKSRGTSTQGTSTHA ECCCCCCCCCCCCCC	30.75	23312004
556	Phosphorylation	RGTSTQGTSTHASST CCCCCCCCCCCCCCC	22.19	23312004
557	Phosphorylation	GTSTQGTSTHASSTQ CCCCCCCCCCCCCCE	25.64	23312004
558	Phosphorylation	TSTQGTSTHASSTQL CCCCCCCCCCCCCEE	22.69	23312004
561	Phosphorylation	QGTSTHASSTQLAMV CCCCCCCCCCEEEEE	26.72	23312004
562	Phosphorylation	GTSTHASSTQLAMVD CCCCCCCCCEEEEEC	22.43	23312004
563	Phosphorylation	TSTHASSTQLAMVDD CCCCCCCCEEEEECC	25.71	23312004
577	Phosphorylation	DQRSKAGSIHSKVSS CCHHHCCCHHHHHHH	23.22	24719451
583	Phosphorylation	GSIHSKVSSYHGSLH CCHHHHHHHHCCCCC	28.99	25159151
584	Phosphorylation	SIHSKVSSYHGSLHR CHHHHHHHHCCCCCC	24.92	25159151
585	Phosphorylation	IHSKVSSYHGSLHRS HHHHHHHHCCCCCCC	11.60	25849741
588	Phosphorylation	KVSSYHGSLHRSRDG HHHHHCCCCCCCCCC	14.00	27251275
597	Phosphorylation	HRSRDGRYTPCSYRG CCCCCCCCCCCCCCC	22.14	24732914
598	Phosphorylation	RSRDGRYTPCSYRGM CCCCCCCCCCCCCCH	19.23	24732914
601	Phosphorylation	DGRYTPCSYRGMEER CCCCCCCCCCCHHHH	21.04	24732914
613	Phosphorylation	EERLPHGSMSRLTDH HHHCCCCCHHHHCCC	15.56	28857561
647	Phosphorylation	DLSNNPMTHITHGTS HHCCCCCCCCCCCCC	16.04	22912867
650	Phosphorylation	NNPMTHITHGTSMNR CCCCCCCCCCCCCCC	13.47	28348404
653	Phosphorylation	MTHITHGTSMNRVIE CCCCCCCCCCCCEEC	19.73	28348404
654	Phosphorylation	THITHGTSMNRVIEE CCCCCCCCCCCEECC	20.74	32142685
664	Phosphorylation	RVIEEDGTSA----- CEECCCCCCC-----	33.53	28348404
665	Phosphorylation	VIEEDGTSA------ EECCCCCCC------	37.19	33259812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FZD3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.