TM39A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM39A_HUMAN
• UniProt AC: Q9NV64
• Protein Name: Transmembrane protein 39A
• Gene Name: TMEM39A
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MPGGRRGPSRQQLSRSALPSLQTLVGGGCGNGTGLRNRNGSAIGLPVPPITALITPGPVRHCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYHLAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARLVLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYVVQHEAVEESASTVGGLAKSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLEHGSYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRLLNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPLNSYELKAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PGGRRGPSRQQLSRS CCCCCCCCHHHHCHH	45.61	-
31	N-linked_Glycosylation	LVGGGCGNGTGLRNR HCCCCCCCCCCCCCC	49.26	UniProtKB CARBOHYD
33	Phosphorylation	GGGCGNGTGLRNRNG CCCCCCCCCCCCCCC	36.72	22210691
39	N-linked_Glycosylation	GTGLRNRNGSAIGLP CCCCCCCCCCCCCCC	52.93	UniProtKB CARBOHYD
41	Phosphorylation	GLRNRNGSAIGLPVP CCCCCCCCCCCCCCC	21.91	22210691
51	Phosphorylation	GLPVPPITALITPGP CCCCCCCEEEEECCC	22.61	22210691
139	Phosphorylation	RLVWALISEATKAGA HHHHHHHHHHHHHCH	23.25	-
142	Phosphorylation	WALISEATKAGAASM HHHHHHHHHHCHHHH	19.85	-
208	Ubiquitination	CFHQDSRAHLLLTDY CCCCCCCCEEEEECC	11.13	21963094
210	Ubiquitination	HQDSRAHLLLTDYNY CCCCCCEEEEECCCH	4.01	22817900
213	Phosphorylation	SRAHLLLTDYNYVVQ CCCEEEEECCCHHHC	36.09	27642862
215	Phosphorylation	AHLLLTDYNYVVQHE CEEEEECCCHHHCHH	11.80	27642862
217	Phosphorylation	LLLTDYNYVVQHEAV EEEECCCHHHCHHHH	8.86	27642862
236	Ubiquitination	STVGGLAKSKDFLSL HCHHHHHHCHHHHHH	64.18	21963094
236 (in isoform 1)	Ubiquitination	-	64.18	21906983
238	Ubiquitination	VGGLAKSKDFLSLLL HHHHHHCHHHHHHHH	52.36	22817900
250	Ubiquitination	LLLESLKEQFNNATP HHHHHHHHHHCCCCC	66.74	27667366
266	Phosphorylation	PTHSCPLSPDLIRNE CCCCCCCCHHHHHHH	11.08	27050516
278	Ubiquitination	RNEVECLKADFNHRI HHHHHHHHCCHHHHH	58.53	29901268
340	Phosphorylation	LTTQLLPSKYCDLLH HHHHHCCHHHHHHHH	35.91	24719451
355	Ubiquitination	KSAAHLGKWQKLEHG HHHHHHCCCEECCCC	53.46	29967540
358	Ubiquitination	AHLGKWQKLEHGSYS HHHCCCEECCCCCCC	55.52	-
391	Phosphorylation	VRHSRCLYRAMGPYN HHCHHHHHHHCCCCC	10.43	-
411	Phosphorylation	DVSHARFYFLFHRPL CCCHHHHHHHHCCHH	8.20	-
458	Ubiquitination	MALILFCNYYVLFKL HHHHHHHHHHHHHHH	24.68	21963094
478	Phosphorylation	VLGRAYSYPLNSYEL HEECCCCCCCCCCCC	10.08	25884760
486	Ubiquitination	PLNSYELKAN----- CCCCCCCCCC-----	33.66	21906983
486 (in isoform 1)	Ubiquitination	-	33.66	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM39A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM39A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM39A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM39A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.