TMTC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMTC3_HUMAN
• UniProt AC: Q6ZXV5
• Protein Name: Transmembrane and TPR repeat-containing protein 3
• Gene Name: TMTC3
• Organism: Homo sapiens (Human).
• Sequence Length: 915
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Endoplasmic reticulum . In odontoblast cultures, it colocalizes with PDIA3 in the endoplasmic reticulum.
• Protein Description: Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response..
• Protein Sequence: MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAALKRLEEIERILNGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	HPSTPLKTLFQNDFW CCCCCHHHHHCCCCC	40.25	24719451
50 (in isoform 2)	Phosphorylation	-	40.25	24719451
66 (in isoform 2)	Phosphorylation	-	38.25	24719451
66	Phosphorylation	TPMSEERSHKSYRPL CCCCCCCCCCCCCCC	38.25	24719451
117	N-linked_Glycosylation	VCKLFLDNKSSVIAS HHHHHHCCHHHHHHH	48.53	UniProtKB CARBOHYD
227	Phosphorylation	QFLRGKGSIPFSMLQ HHHCCCCCCCHHHHH	30.49	21406692
231	Phosphorylation	GKGSIPFSMLQTLVK CCCCCCHHHHHHHHH	17.15	21406692
235	Phosphorylation	IPFSMLQTLVKLIVL CCHHHHHHHHHHHHH	29.56	21406692
274	Phosphorylation	FDNPAAVSPTPTRQL CCCCCCCCCCCCCCE	20.52	-
337	O-linked_Glycosylation	LGMLGVFSIRYSGDS HHHHHHHHCCCCCCC	12.07	29351928
460	Ubiquitination	GHALENEKNFERALK HHHHHCHHHHHHHHH	77.76	21890473
460 (in isoform 2)	Ubiquitination	-	77.76	21890473
460 (in isoform 1)	Ubiquitination	-	77.76	21890473
468	Phosphorylation	NFERALKYFLQATHV HHHHHHHHHHHHCCC	15.46	24719451
473	Phosphorylation	LKYFLQATHVQPDDI HHHHHHHCCCCCCHH	15.04	24719451
490	Phosphorylation	HMNVGRTYKNLNRTK HCCCCCHHHCCCCCH	9.12	-
494	N-linked_Glycosylation	GRTYKNLNRTKEAEE CCHHHCCCCCHHHHH	59.99	UniProtKB CARBOHYD
503 (in isoform 2)	Phosphorylation	-	8.32	-
503	Phosphorylation	TKEAEESYMMAKSLM CHHHHHHHHHHHHHC	8.32	18669648
517	2-Hydroxyisobutyrylation	MPQIIPGKKYAARIA CCCCCCCCCHHHHHC	36.94	-
541	N-linked_Glycosylation	LANLIRANESRLEEA HHHHHHHCHHHHHHH	37.62	UniProtKB CARBOHYD
552	Phosphorylation	LEEADQLYRQAISMR HHHHHHHHHHHHHCC	8.61	21406692
563	Acetylation	ISMRPDFKQAYISRG HHCCCCHHHHHHHHH	41.20	26051181
737 (in isoform 2)	Ubiquitination	-	5.02	21890473
738	2-Hydroxyisobutyrylation	RYYPDHIKGLILKGD HHCCHHHCEEEECCC	44.22	-
738 (in isoform 1)	Ubiquitination	-	44.22	21890473
738	Ubiquitination	RYYPDHIKGLILKGD HHCCHHHCEEEECCC	44.22	21890473
743	Acetylation	HIKGLILKGDILMNQ HHCEEEECCCHHHCC	47.76	7711367
782	Phosphorylation	KHNLCVVYFEEKDLL CCEEEEEEECHHHHH	5.72	-
821	Phosphorylation	IVRDKISSSSFIEPI HHHHHHCCCCCCCCC	33.21	24114839
823	Phosphorylation	RDKISSSSFIEPIFP HHHHCCCCCCCCCCC	31.99	-
831	O-linked_Glycosylation	FIEPIFPTSKISSVE CCCCCCCCCCCEECC	31.72	OGP
832	Phosphorylation	IEPIFPTSKISSVEG CCCCCCCCCCEECCC	28.38	24114839
844	O-linked_Glycosylation	VEGKKIPTESVKEIR CCCCCCCCHHHHHHC	44.35	OGP
857	Phosphorylation	IRGESRQTQIVKTSD HCCCCCCEEEEECCC	21.10	29083192
887	Phosphorylation	DEETPHKTTKDIKEI CCCCCCCCHHHHHHH	35.72	26074081
888	Phosphorylation	EETPHKTTKDIKEIE CCCCCCCHHHHHHHH	31.36	26074081
896	Acetylation	KDIKEIEKKRVAALK HHHHHHHHHHHHHHH	52.09	12433699
897	Acetylation	DIKEIEKKRVAALKR HHHHHHHHHHHHHHH	39.04	12433707

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMTC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMTC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMTC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COTL1_HUMAN	COTL1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-503, AND MASSSPECTROMETRY.
PubMed: 18669648