SPP2B_HUMAN - dbPTM
SPP2B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPP2B_HUMAN
UniProt AC Q8TCT7
Protein Name Signal peptide peptidase-like 2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}
Gene Name SPPL2B {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30627}
Organism Homo sapiens (Human).
Sequence Length 592
Subcellular Localization Cell membrane
Multi-pass membrane protein . Golgi apparatus membrane
Multi-pass membrane protein . Lysosome membrane
Multi-pass membrane protein . Endosome membrane
Multi-pass membrane protein . Membrane
Multi-pass membrane protein
Lumenal sid
Protein Description Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. [PubMed: 16829952]
Protein Sequence MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
97N-linked_GlycosylationIPLVARGNCTFYEKV
CCEEECCCCEEHHHH		18.99UniProtKB CARBOHYD
103UbiquitinationGNCTFYEKVRLAQGS
CCCEEHHHHHHHCCC		22.67-
119PhosphorylationARGLLIVSRERLVPP
CCEEEEEECCEECCC		22.7924719451
129N-linked_GlycosylationRLVPPGGNKTQYDEI
EECCCCCCCCCHHCC		50.55UniProtKB CARBOHYD
131PhosphorylationVPPGGNKTQYDEIGI
CCCCCCCCCHHCCCC		36.04-
133PhosphorylationPGGNKTQYDEIGIPV
CCCCCCCHHCCCCCH		22.30-
145PhosphorylationIPVALLSYKDMLDIF
CCHHHHHHHHHHHHH		15.81-
173PhosphorylationPKEPVLDYNMVIIFI
CCCCCCCCCCEEEEE		10.86-
206UbiquitinationKKRYMKHKRDDGPEK
HHHHHHHCCCCCCCC		52.59-
385PhosphorylationVEVATGPSDSATREK
EEEECCCCCCCHHHH		45.61-
387PhosphorylationVATGPSDSATREKLP
EECCCCCCCHHHHCC		35.56-
389PhosphorylationTGPSDSATREKLPMV
CCCCCCCHHHHCCEE		43.23-
398UbiquitinationEKLPMVLKVPRLNSS
HHCCEEEECCCCCCC		38.49-
508 (in isoform 4)Phosphorylation-5.21-
509 (in isoform 4)Phosphorylation-30.25-
511PhosphorylationFAKVLPPSPWAPAPA
CCCCCCCCCCCCCCC		31.0025159151
532PhosphorylationKDSATPLSPQPPSEE
CCCCCCCCCCCCCCC		23.7726657352
537PhosphorylationPLSPQPPSEEPATSP
CCCCCCCCCCCCCCC		62.3626074081
542PhosphorylationPPSEEPATSPWPAEQ
CCCCCCCCCCCCCHH		46.1426074081
543PhosphorylationPSEEPATSPWPAEQS
CCCCCCCCCCCCHHC		27.3723403867
550PhosphorylationSPWPAEQSPKSRTSE
CCCCCHHCCCCCCCH		26.2923401153
553PhosphorylationPAEQSPKSRTSEEMG
CCHHCCCCCCCHHCC		44.1428348404
555PhosphorylationEQSPKSRTSEEMGAG
HHCCCCCCCHHCCCC		47.8028348404
556PhosphorylationQSPKSRTSEEMGAGA
HCCCCCCCHHCCCCC		30.3728348404
574PhosphorylationEPGSPAESEGRDQAQ
CCCCCCCCCCCCCCC		47.6722210691
583PhosphorylationGRDQAQPSPVTQPGA
CCCCCCCCCCCCCCC		21.6625627689
586PhosphorylationQAQPSPVTQPGASA-
CCCCCCCCCCCCCC-		32.2221955146
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPP2B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPP2B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPP2B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZNT5_HUMANSLC30A5physical
28514442
PIGN_HUMANPIGNphysical
28514442
KTN1_HUMANKTN1physical
28514442
ZNT6_HUMANSLC30A6physical
28514442
S35G2_HUMANSLC35G2physical
28514442
IGSF3_HUMANIGSF3physical
28514442
P2RX4_HUMANP2RX4physical
28514442
TMM8A_HUMANTMEM8Aphysical
28514442
PIGW_HUMANPIGWphysical
28514442
MTCH1_HUMANMTCH1physical
28514442
MFSD5_HUMANMFSD5physical
28514442
CDR2_HUMANCDR2physical
28514442
GSLG1_HUMANGLG1physical
28514442
NBR1_HUMANNBR1physical
28514442
ATP9A_HUMANATP9Aphysical
28514442
UBP28_HUMANUSP28physical
28514442
MET7A_HUMANMETTL7Aphysical
28514442
OSBL8_HUMANOSBPL8physical
28514442
NDUC2_HUMANNDUFC2physical
28514442
TSN3_HUMANTSPAN3physical
28514442
TXD15_HUMANTXNDC15physical
28514442
TMM43_HUMANTMEM43physical
28514442
FITM2_HUMANFITM2physical
28514442
TLCD1_HUMANTLCD1physical
28514442
EXTL2_HUMANEXTL2physical
28514442
PSME2_HUMANPSME2physical
28514442
TMED1_HUMANTMED1physical
28514442
ENDD1_HUMANENDOD1physical
28514442
BRI3B_HUMANBRI3BPphysical
28514442
GHITM_HUMANGHITMphysical
28514442
TM186_HUMANTMEM186physical
28514442
S19A2_HUMANSLC19A2physical
28514442
CEP44_HUMANCEP44physical
28514442
TV23C_HUMANTVP23Cphysical
28514442
MRS2_HUMANMRS2physical
28514442
NDUB1_HUMANNDUFB1physical
28514442
S39A1_HUMANSLC39A1physical
28514442
PON2_HUMANPON2physical
28514442
CASC4_HUMANCASC4physical
28514442
ERGI2_HUMANERGIC2physical
28514442
NDUB8_HUMANNDUFB8physical
28514442
S35F2_HUMANSLC35F2physical
28514442
ABCB8_HUMANABCB8physical
28514442
TMED9_HUMANTMED9physical
28514442
YIPF4_HUMANYIPF4physical
28514442
SURF4_HUMANSURF4physical
28514442
PAQR1_HUMANADIPOR1physical
28514442
PLD6_HUMANPLD6physical
28514442
FXYD6_HUMANFXYD6physical
28514442
SPPL3_HUMANSPPL3physical
28514442
CADM1_HUMANCADM1physical
28514442
GOGA5_HUMANGOLGA5physical
28514442
QCR8_HUMANUQCRQphysical
28514442
HACD2_HUMANPTPLBphysical
28514442
PIGU_HUMANPIGUphysical
28514442
AG10A_HUMANALG10physical
28514442
PSN1_HUMANPSEN1physical
28514442
LMAN2_HUMANLMAN2physical
28514442
MTCH2_HUMANMTCH2physical
28514442
RMND1_HUMANRMND1physical
28514442
COT2_HUMANNR2F2physical
28514442
AT1A3_HUMANATP1A3physical
28514442
BI1_HUMANTMBIM6physical
28514442
PPAL_HUMANACP2physical
28514442
EXTL3_HUMANEXTL3physical
28514442
MAVS_HUMANMAVSphysical
28514442
S52A2_HUMANSLC52A2physical
28514442
S35B2_HUMANSLC35B2physical
28514442
XYLK_HUMANFAM20Bphysical
28514442
CKLF4_HUMANCMTM4physical
28514442
CHPT1_HUMANCHPT1physical
28514442
ERD23_HUMANKDELR3physical
28514442
YIPF6_HUMANYIPF6physical
28514442
COX1_HUMANCOX1physical
28514442
GPC5C_HUMANGPRC5Cphysical
28514442
TMED4_HUMANTMED4physical
28514442
SERC1_HUMANSERINC1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPP2B_HUMAN

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Related Literatures of Post-Translational Modification

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