| UniProt ID | ABCB8_HUMAN | |
|---|---|---|
| UniProt AC | Q9NUT2 | |
| Protein Name | ATP-binding cassette sub-family B member 8, mitochondrial | |
| Gene Name | ABCB8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 735 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . |
|
| Protein Description | ||
| Protein Sequence | MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 247 (in isoform 1) | Ubiquitination | - | 56.61 | 21906983 | |
| 263 (in isoform 1) | Ubiquitination | - | 44.42 | 21906983 | |
| 496 (in isoform 2) | Ubiquitination | - | 33.87 | 21906983 | |
| 513 (in isoform 1) | Ubiquitination | - | 44.27 | 21906983 | |
| 573 (in isoform 1) | Ubiquitination | - | 40.20 | 21906983 | |
| 628 (in isoform 1) | Ubiquitination | - | 51.58 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ABCB8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABCB8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABCB8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RFIP5_HUMAN | RAB11FIP5 | physical | 22939629 | |
| ADPGK_HUMAN | ADPGK | physical | 22939629 | |
| GRP1_HUMAN | RASGRP1 | physical | 22939629 | |
| MTEF3_HUMAN | MTERF3 | physical | 22939629 | |
| LDH6B_HUMAN | LDHAL6B | physical | 22939629 | |
| EPCR_HUMAN | PROCR | physical | 22939629 | |
| IMPA3_HUMAN | IMPAD1 | physical | 22939629 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00997 | Doxorubicin |
loading...
