| UniProt ID | ADPGK_HUMAN | |
|---|---|---|
| UniProt AC | Q9BRR6 | |
| Protein Name | ADP-dependent glucokinase | |
| Gene Name | ADPGK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 497 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).. | |
| Protein Sequence | MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEVHPHY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 104 | Ubiquitination | GLSPGNGKDHSILHS CCCCCCCCCCCCCCC | 57.16 | - | |
| 125 | Ubiquitination | AFIHFMGKGAAAERF HHHHHHCCHHHHHHH | 33.32 | 21963094 | |
| 136 | Ubiquitination | AERFFSDKETFHDIA HHHHHCCHHHHHHHH | 58.41 | 29967540 | |
| 166 | Ubiquitination | NAALIGQKFAANSDL CEEHHCCHHHCCCCC | 31.58 | 29967540 | |
| 370 | Acetylation | LKEHGRSKSRASDLT HHHHCCCCCCHHHHH | 42.47 | 7977309 | |
| 412 | Phosphorylation | AGARVAGTQACATET HCCCCCCCCCCCCCE | 11.85 | 68733355 | |
| 415 | Glutathionylation | RVAGTQACATETIDT CCCCCCCCCCCEECC | 3.28 | 22555962 | |
| 417 | Phosphorylation | AGTQACATETIDTSR CCCCCCCCCEECCCC | 33.28 | 68733361 | |
| 423 | Phosphorylation | ATETIDTSRVSLRAP CCCEECCCCCCCCCC | 27.26 | 68733367 | |
| 434 | Sulfoxidation | LRAPQEFMTSHSEAG CCCCHHHHCCCCCCC | 3.55 | 30846556 | |
| 450 | Ubiquitination | RIVLNPNKPVVEWHR EEEECCCCCCEEEEC | 40.21 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ADPGK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADPGK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADPGK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TIMP3_HUMAN | TIMP3 | physical | 28514442 | |
| GALT7_HUMAN | GALNT7 | physical | 28514442 | |
| CGT_HUMAN | UGT8 | physical | 28514442 | |
| TOR1B_HUMAN | TOR1B | physical | 28514442 | |
| MGAT1_HUMAN | MGAT1 | physical | 28514442 | |
| EPHB4_HUMAN | EPHB4 | physical | 28514442 | |
| EXTL2_HUMAN | EXTL2 | physical | 28514442 | |
| MIPEP_HUMAN | MIPEP | physical | 28514442 | |
| CCPG1_HUMAN | CCPG1 | physical | 28514442 | |
| PDIA5_HUMAN | PDIA5 | physical | 28514442 | |
| F213A_HUMAN | FAM213A | physical | 28514442 | |
| TM214_HUMAN | TMEM214 | physical | 28514442 | |
| PXDN_HUMAN | PXDN | physical | 28514442 | |
| GALT4_HUMAN | GALNT4 | physical | 28514442 | |
| C1GLC_HUMAN | C1GALT1C1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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