GALT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALT4_HUMAN
• UniProt AC: Q8N4A0
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 4
• Gene Name: GALNT4
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG..
• Protein Sequence: MAVRWTWAGKSCLLLAFLTVAYIFVELLVSTFHASAGAGRARELGSRRLSDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSFEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	ELGSRRLSDLQKNTE HHHHHHHHHHHHCCH	34.17	29978859
51	Ubiquitination	LGSRRLSDLQKNTED HHHHHHHHHHHCCHH	58.68	29967540
54	Ubiquitination	RRLSDLQKNTEDLSR HHHHHHHHCCHHCCC	73.47	29967540
56	Phosphorylation	LSDLQKNTEDLSRPL HHHHHHCCHHCCCCH	37.60	29978859
60	Phosphorylation	QKNTEDLSRPLYKKP HHCCHHCCCCHHCCC	44.14	29978859
71	Phosphorylation	YKKPPADSRALGEWG HCCCCCCCCCHHCHH	22.89	28857561
79	Ubiquitination	RALGEWGKASKLQLN CCHHCHHHHHHCCCC	51.03	29967540
82	Ubiquitination	GEWGKASKLQLNEDE HCHHHHHHCCCCHHH	45.15	29967540
133	Phosphorylation	SQKFNYRTLPTTSVI CCCCCCCCCCCCEEE	27.08	25348772
136	Phosphorylation	FNYRTLPTTSVIIAF CCCCCCCCCEEEEEE	34.51	25348772
137	Phosphorylation	NYRTLPTTSVIIAFY CCCCCCCCEEEEEEC	21.03	25348772
138	Phosphorylation	YRTLPTTSVIIAFYN CCCCCCCEEEEEECH	17.50	24248375
144	Phosphorylation	TSVIIAFYNEAWSTL CEEEEEECHHHHHHH	11.76	25348772
149	Phosphorylation	AFYNEAWSTLLRTIH EECHHHHHHHHHHHH	19.07	24248375
154	Phosphorylation	AWSTLLRTIHSVLET HHHHHHHHHHHHHHC	24.02	-
157	Phosphorylation	TLLRTIHSVLETSPA HHHHHHHHHHHCCHH	25.25	-
161	Phosphorylation	TIHSVLETSPAVLLK HHHHHHHCCHHHHHE	35.53	24248375
177	Phosphorylation	IILVDDLSDRVYLKT EEEEECCCCCEEHHH	30.30	24670416
181	Phosphorylation	DDLSDRVYLKTQLET ECCCCCEEHHHHHHH	11.90	18083107
291	Methylation	FQWHSVPKQERDRRI EEEECCCHHHHCCCH	63.74	23644510
306	Phosphorylation	SRIDPIRSPTMAGGL HCCCCCCCCCCCCCH	25.99	24719451
308	Phosphorylation	IDPIRSPTMAGGLFA CCCCCCCCCCCCHHH	22.39	24719451
379	O-linked_Glycosylation	RPNFLQNTARAAEVW CCCHHHHHHHHHHHH	12.45	29351928
390	Phosphorylation	AEVWMDEYKEHFYNR HHHHHHHHHHHHHCC	19.88	-
410	Phosphorylation	KEAYGDISERKLLRE HHHHCCCHHHHHHHH	35.77	-
471	N-linked_Glycosylation	DNNPTGANLSLFGCH CCCCCCCCEEEEEEC	31.35	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUC1_HUMAN	MUC1	physical	12754287

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.