| UniProt ID | MGAT1_HUMAN | |
|---|---|---|
| UniProt AC | P26572 | |
| Protein Name | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | |
| Gene Name | MGAT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 445 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein. |
|
| Protein Description | Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.. | |
| Protein Sequence | MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 39 | O-linked_Glycosylation | PAPGRPPSVSALDGD CCCCCCCCCHHCCCC | 31.24 | OGP | |
| 88 | O-linked_Glycosylation | SQRGRVPTAAPPAQP HCCCCCCCCCCCCCC | 32.37 | 46251091 | |
| 88 | Phosphorylation | SQRGRVPTAAPPAQP HCCCCCCCCCCCCCC | 32.37 | - | |
| 100 | O-linked_Glycosylation | AQPRVPVTPAPAVIP CCCCCCCCCCCCCEE | 13.99 | OGP | |
| 100 | Phosphorylation | AQPRVPVTPAPAVIP CCCCCCCCCCCCCEE | 13.99 | - | |
| 309 | Phosphorylation | ACIRPEISRTMTFGR CCCCHHHHCCEECCC | 21.75 | 25841592 | |
| 311 | Phosphorylation | IRPEISRTMTFGRKG CCHHHHCCEECCCCC | 17.48 | 25841592 | |
| 313 | Phosphorylation | PEISRTMTFGRKGVS HHHHCCEECCCCCCC | 23.48 | 25841592 | |
| 320 | O-linked_Glycosylation | TFGRKGVSHGQFFDQ ECCCCCCCCCHHHHH | 30.48 | 55824167 | |
| 372 | Ubiquitination | APQLQVEKVRTNDRK CCCEEEEEEECCCCH | 37.85 | - | |
| 399 | Ubiquitination | DSFKAFAKALGVMDD HHHHHHHHHHCCHHH | 37.38 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MGAT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MGAT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MGAT1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MGAT1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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