TOR1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOR1B_HUMAN
• UniProt AC: O14657
• Protein Name: Torsin-1B
• Gene Name: TOR1B
• Organism: Homo sapiens (Human).
• Sequence Length: 336
• Subcellular Localization: Endoplasmic reticulum lumen . Nucleus membrane .
• Protein Description: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues..
• Protein Sequence: MLRAGWLRGAAALALLLAARVVAAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREERPLNASALKLDLEEKLFGQHLATEVIFKALTGFRNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQLKDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTRVAEEMTFFPRDEKIYSDKGCKTVQSRLDFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	O-linked_Glycosylation	GLAIGAASAITGYLS HHHHHHHHHHHCCCC	21.48	55835209
41	O-linked_Glycosylation	IGAASAITGYLSYND HHHHHHHHCCCCCHH	21.35	55835215
64	N-linked_Glycosylation	CREERPLNASALKLD HCCCCCCCHHHHCCC	34.23	UniProtKB CARBOHYD
91	Phosphorylation	EVIFKALTGFRNNKN HHHHHHHHCCCCCCC	38.85	24719451
104	Phosphorylation	KNPKKPLTLSLHGWA CCCCCCEEEEEECCC	23.87	-
106	Phosphorylation	PKKPLTLSLHGWAGT CCCCEEEEEECCCCC	17.06	-
113	Phosphorylation	SLHGWAGTGKNFVSQ EEECCCCCCHHHHHH	36.92	-
119	Phosphorylation	GTGKNFVSQIVAENL CCCHHHHHHHHHHCC	15.28	22210691
165	N-linked_Glycosylation	LQKWIRGNVSACANS HHHHHHCCHHHHCCC	18.09	UniProtKB CARBOHYD
214	Phosphorylation	KAIFIFLSNAGGDLI HHHEEEEECCCCCHH	17.55	-
222	Phosphorylation	NAGGDLITKTALDFW CCCCCHHHHHHHHHH	29.64	-
224	Phosphorylation	GGDLITKTALDFWRA CCCHHHHHHHHHHHC	24.65	-
324	2-Hydroxyisobutyrylation	DEKIYSDKGCKTVQS CCCCCCCCCCCCHHH	61.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOR1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOR1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOR1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GHITM_HUMAN	GHITM	physical	26186194
LMA2L_HUMAN	LMAN2L	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.