LMA2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMA2L_HUMAN
• UniProt AC: Q9H0V9
• Protein Name: VIP36-like protein
• Gene Name: LMAN2L
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
• Protein Description: May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53..
• Protein Sequence: MAATLGPLGSWQQWRRCLSARDGSRMLLLLLLLGSGQGPQQVGAGQTFEYLKREHSLSKPYQGVGTGSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFKIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQERVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	QGVGTGSSSLWNLMG CCCCCCCHHHHHHHH	30.69	22210691
70	O-linked_Glycosylation	GVGTGSSSLWNLMGN CCCCCCHHHHHHHHC	38.82	29351928
93	Phosphorylation	RLTPDMQSKQGALWN EECCCCHHHCCHHHC	21.95	22210691
94	Ubiquitination	LTPDMQSKQGALWNR ECCCCHHHCCHHHCC	35.54	-
94 (in isoform 2)	Ubiquitination	-	35.54	-
181	N-linked_Glycosylation	YISAMVNNGSLSYDH HHHHHCCCCCCCCCC	29.98	12878160
231	Acetylation	IMMDIDGKHEWRDCI EEEECCCCCCCCCCE	34.30	19859085
249	Phosphorylation	GVRLPRGYYFGTSSI CCCCCCCEEEECCCE	9.26	18083107
250	Phosphorylation	VRLPRGYYFGTSSIT CCCCCCEEEECCCEE	9.80	18083107
268	Phosphorylation	SDNHDVISLKLFELT CCCCCEEEEEEEEEE	21.21	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMA2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMA2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMA2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGH2_HUMAN	PTGS2	physical	28514442
CNTP1_HUMAN	CNTNAP1	physical	28514442
ABCA2_HUMAN	ABCA2	physical	28514442
ITA1_HUMAN	ITGA1	physical	28514442
SUSD1_HUMAN	SUSD1	physical	28514442
TM245_HUMAN	TMEM245	physical	28514442
TEN3_HUMAN	TENM3	physical	28514442
LCAP_HUMAN	LNPEP	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
CA2D1_HUMAN	CACNA2D1	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
ADA17_HUMAN	ADAM17	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
ENPP4_HUMAN	ENPP4	physical	28514442
TTC17_HUMAN	TTC17	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
MRC2_HUMAN	MRC2	physical	28514442
CGT_HUMAN	UGT8	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.