K319L_HUMAN - dbPTM
K319L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K319L_HUMAN
UniProt AC Q8IZA0
Protein Name Dyslexia-associated protein KIAA0319-like protein {ECO:0000305|PubMed:20697954}
Gene Name KIAA0319L {ECO:0000312|HGNC:HGNC:30071}
Organism Homo sapiens (Human).
Sequence Length 1049
Subcellular Localization Cytoplasmic granule membrane
Multi-pass membrane protein . Golgi apparatus membrane
Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Traffics
Protein Description Possible role in axon guidance through interaction with RTN4R.; (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system..
Protein Sequence MEKRLGVKPNPASWILSGYYWQTSAKWLRSLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCWAACCQDSACHVFWWLEGMCIQADCSRPQSCRAFRTHSSNSMLVFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSDVVTPIVTQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELSGGPKNVSVQPEISEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYATPTPQASFQSTSAPYPVIKELVVSAGESVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKPEPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEVNTVTCQLNCSDHGHCDSFTKRCICDPFWMENFIKVQLRDGDSNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGIKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
176O-linked_GlycosylationALRPAVSSSDQQSLI
HHCCCCCCHHHHHHH		31.19OGP
177O-linked_GlycosylationLRPAVSSSDQQSLIR
HCCCCCCHHHHHHHH		31.7555833771
181PhosphorylationVSSSDQQSLIRKLQK
CCCHHHHHHHHHHHH		21.8224719451
197O-linked_GlycosylationGSPSDVVTPIVTQHS
CCHHHCCCCCCCCCC		13.7255831595
201O-linked_GlycosylationDVVTPIVTQHSKVND
HCCCCCCCCCCCCCC		22.6855831601
204O-linked_GlycosylationTPIVTQHSKVNDSNE
CCCCCCCCCCCCCCC		28.6055831605
216O-linked_GlycosylationSNELGGLTTSGSAEV
CCCCCCCCCCCCCEE		23.38OGP
217O-linked_GlycosylationNELGGLTTSGSAEVH
CCCCCCCCCCCCEEE		35.81OGP
234O-linked_GlycosylationITISSPLTTDLTAEL
EEECCCCCCCHHHHH		22.96OGP
235O-linked_GlycosylationTISSPLTTDLTAELS
EECCCCCCCHHHHHC		36.37OGP
238O-linked_GlycosylationSPLTTDLTAELSGGP
CCCCCCHHHHHCCCC		22.39OGP
247N-linked_GlycosylationELSGGPKNVSVQPEI
HHCCCCCCEECCCCC		34.14UniProtKB CARBOHYD
260O-linked_GlycosylationEISEGLATTPSTQQV
CCCCCCCCCCCCCCC		44.26OGP
298O-linked_GlycosylationTPQASFQSTSAPYPV
CCCCCCCCCCCCCHH		23.48OGP
299O-linked_GlycosylationPQASFQSTSAPYPVI
CCCCCCCCCCCCHHH		20.37OGP
312PhosphorylationVIKELVVSAGESVQI
HHEEEEECCCCEEEE		24.0727732954
316PhosphorylationLVVSAGESVQITLPK
EEECCCCEEEEECCC		20.5727732954
320PhosphorylationAGESVQITLPKNEVQ
CCCEEEEECCCCEEE		21.6627732954
395N-linked_GlycosylationAHGEGYVNVTVKPEP
CCCCCEEEEEECCCC		18.43UniProtKB CARBOHYD
425O-linked_GlycosylationEISLPTTSTVIDGSQ
CCCCCCCCEEEECCC		24.13OGP
434O-linked_GlycosylationVIDGSQSTDDDKIVQ
EEECCCCCCCCHHHH		35.49OGP
472N-linked_GlycosylationLSKLVPGNYTFSLTV
HHHCCCCCEEEEEEE		26.9719159218
487N-linked_GlycosylationVDSDGATNSTTANLT
ECCCCCCCCCEEEEE		36.50UniProtKB CARBOHYD
525N-linked_GlycosylationNSITLFGNQSTDDHG
CCEEEECCCCCCCCC		25.8719159218
555MethylationVVEMQGVRTPTLQLS
EEEECCCCCCEEEEE		41.6424376885
555DimethylationVVEMQGVRTPTLQLS
EEEECCCCCCEEEEE		41.64-
569PhosphorylationSAMQEGDYTYQLTVT
EECCCCCEEEEEEEE		20.4324043423
570PhosphorylationAMQEGDYTYQLTVTD
ECCCCCEEEEEEEEC		14.9924043423
571PhosphorylationMQEGDYTYQLTVTDT
CCCCCEEEEEEEECC		8.6924043423
574PhosphorylationGDYTYQLTVTDTIGQ
CCEEEEEEEECCCCC		13.0624043423
576PhosphorylationYTYQLTVTDTIGQQA
EEEEEEEECCCCCEE		23.3824043423
578PhosphorylationYQLTVTDTIGQQATA
EEEEEECCCCCEEEE		20.0324043423
584PhosphorylationDTIGQQATAQVTVIV
CCCCCEEEEEEEEEE		17.1824043423
588PhosphorylationQQATAQVTVIVQPEN
CEEEEEEEEEECCCC		7.7624043423
588O-linked_GlycosylationQQATAQVTVIVQPEN
CEEEEEEEEEECCCC		7.76OGP
677PhosphorylationKDERNLQSQSSVNVI
CCCCCCCCCCCEEEE		34.88-
677O-linked_GlycosylationKDERNLQSQSSVNVI
CCCCCCCCCCCEEEE		34.88OGP
679PhosphorylationERNLQSQSSVNVIVK
CCCCCCCCCEEEEEE		41.31-
680PhosphorylationRNLQSQSSVNVIVKE
CCCCCCCCEEEEEEC		15.29-
698PhosphorylationKPPIAKITGNVVITL
CCCCCEEECCEEEEC		23.2320068231
704PhosphorylationITGNVVITLPTSTAE
EECCEEEECCCCCEE		18.3120068231
707PhosphorylationNVVITLPTSTAELDG
CEEEECCCCCEECCC		41.6520068231
708PhosphorylationVVITLPTSTAELDGS
EEEECCCCCEECCCC		24.5520068231
709PhosphorylationVITLPTSTAELDGSK
EEECCCCCEECCCCC		26.9920068231
715PhosphorylationSTAELDGSKSSDDKG
CCEECCCCCCCCCCC		29.0920068231
725PhosphorylationSDDKGIVSYLWTRDE
CCCCCCEEEEEECCC		16.7623403867
726PhosphorylationDDKGIVSYLWTRDEG
CCCCCEEEEEECCCC		8.7223403867
729PhosphorylationGIVSYLWTRDEGSPA
CCEEEEEECCCCCCC		26.1623403867
824PhosphorylationVLLGVLDSDIIVQKI
HHHHHCCCCEEEEEC		26.92-
899PhosphorylationSDHGHCDSFTKRCIC
CCCCCCHHHCCEECC		39.9624719451
974PhosphorylationKYKILDATDQESLEL
CCEEECCCCHHHCCC		37.5725159151
978PhosphorylationLDATDQESLELKPTS
ECCCCHHHCCCCCCC		22.8523401153
982UbiquitinationDQESLELKPTSRAGI
CHHHCCCCCCCCCCC		36.5532015554
984PhosphorylationESLELKPTSRAGIKQ
HHCCCCCCCCCCCCH		29.2923403867
985PhosphorylationSLELKPTSRAGIKQK
HCCCCCCCCCCCCHH		28.7628122231
997PhosphorylationKQKGLLLSSSLMHSE
CHHCEECCCCCCCCC		20.1829514088
998PhosphorylationQKGLLLSSSLMHSES
HHCEECCCCCCCCCH		27.7129514088
999PhosphorylationKGLLLSSSLMHSESE
HCEECCCCCCCCCHH		26.7429514088
1003PhosphorylationLSSSLMHSESELDSD
CCCCCCCCCHHCCCC		28.9329514088
1005PhosphorylationSSLMHSESELDSDDA
CCCCCCCHHCCCCCC		46.6129514088
1009PhosphorylationHSESELDSDDAIFTW
CCCHHCCCCCCCCCC		50.4429514088
1015PhosphorylationDSDDAIFTWPDREKG
CCCCCCCCCCCCCCC		29.9429514088
1031PhosphorylationLLHGQNGSVPNGQTP
CCCCCCCCCCCCCCC		41.7823917254
1037PhosphorylationGSVPNGQTPLKARSP
CCCCCCCCCCCCCCC		31.8025159151
1043PhosphorylationQTPLKARSPREEIL-
CCCCCCCCCCHHCC-		32.9228355574
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K319L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K319L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K319L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K319L_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K319L_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-472 AND ASN-525, AND MASSSPECTROMETRY.

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